Check a pair

Supplements for Digestion

Digestion: 71 compounds are used here, 42 of them at evidence level A. The most used is Lactase. Between them there are 394 documented interactions — which is why the order and timing of a stack matters as much as the choice.

71 compounds
394 interactions
42 evidence A

Where the evidence is strongest

Ranked by popularity, with what each one actually does

Lactase

Lactose digestion & dairy tolerance

3,000-9,000 ALU units With dairy consumption Evidence A Very high absorption

Lactobacillus acidophilus

Lactose tolerance & vaginal health

1-20 billion CFU With meals especially dairy Evidence A Very high absorption

Protease

Protein digestion & amino acid absorption

20,000-60,000 HUT units With protein rich meals Evidence A Very high absorption

Lactobacillus rhamnosus

Immune support & antibiotic protection

1-20 billion CFU With meals or during antibiotics Evidence A Very high absorption

Lipase

Fat digestion & absorption

5,000-25,000 FIP units With fatty meals Evidence A Very high absorption

What these are, chemically

7 types
Probiotics 24 Enzymes 13 Compounds 11 Minerals 9 Botanicals 7 Fatty Acids 3 Amino Acids 2

Most searched here

what people in this group actually look up
Probiotics for Autoimmune Disease Support Gut health & immune modulation 10-100 billion CFU daily B 60% Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 90% Magnesium Citrate Balanced absorption & digestive support 300-600 mg A 35% Chloride Electrolyte & digestive support 2300mg A 95% Bone Broth Collagen Gut healing & collagen support 20-40g powder B 85% Psyllium Husk Digestive health & cholesterol support 5-15g A 95%

Which form to buy

the question people actually search
Best form of Iron 4 forms Iron Bisglycinate · 90% Best form of Magnesium 6 forms Magnesium L-Threonate · 95% Best form of Collagen 7 forms Marine Collagen · 95% Best form of Zinc 5 forms Zinc Picolinate · 95% Best form of Calcium 4 forms Calcium Citrate · 45% Best form of Vitamin C 8 forms Vitamin C (Liposomal) · 95% Best form of Omega 5 forms Krill Oil · 95%

Choosing between forms

Same compound, different absorption
Magnesium Citrate vs Magnesium Glycinate 35% · 90% Zinc Bisglycinate vs Zinc Citrate 85% · 70% Zinc Carnosine vs Zinc Citrate 85% · 70% Zinc Bisglycinate vs Zinc Carnosine 85% · 85% Iron Bisglycinate vs Iron Fumarate 90% · 25%

All 71 compounds

dose · evidence · documented interactions
Lactase Lactose digestion & dairy tolerance 3,000-9,000 ALU units A 6 Lactobacillus acidophilus Lactose tolerance & vaginal health 1-20 billion CFU A 6 Protease Protein digestion & amino acid absorption 20,000-60,000 HUT units A 6 Lactobacillus rhamnosus Immune support & antibiotic protection 1-20 billion CFU A 6 Lipase Fat digestion & absorption 5,000-25,000 FIP units A 6 Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 5 Amylase Carbohydrate digestion & starch breakdown 5,000-20,000 SKB units A 6 Bifidobacterium lactis Digestive regularity & lactose tolerance 1-20 billion CFU A 6 Papain Protein digestion & anti-inflammatory support 500-1,500 mg B 6 Magnesium Citrate Balanced absorption & digestive support 300-600 mg A 5 Ginger Digestive health & anti-nausea 250-1000mg A 5 Saccharomyces boulardii Antibiotic protection & pathogen resistance 250-500mg A 6 Iron Fumarate Gentle iron with good absorption 65-130 mg A 6 Krill Oil Superior omega-3 absorption & cardiovascular health 500-1,500 mg B 6 Bifidobacterium longum Digestive & immune health 1-20 billion CFU A 6 Avocado Oil Heart health & nutrient absorption 15-30ml B 5 Lactobacillus casei Digestive health & immune support 1-20 billion CFU A 6 Zinc Citrate Balanced absorption daily zinc 15-25 mg A 6 Bifidobacterium animalis Digestive regularity & immune support 1-20 billion CFU A 6 Multi-Strain Probiotic Digestive & immune health 10-50 billion CFU A 6 Zinc Bisglycinate Superior absorption immune support 15-25 mg A 6 Saccharomyces cerevisiae Nutritional support & B vitamins 1-2 tablespoons B 6 Bifidobacterium bifidum Digestive & women's health 1-20 billion CFU A 6 Lactobacillus plantarum IBS relief & nutrient absorption 5-20 billion CFU A 6 Probiotics for Autoimmune Disease Support Gut health & immune modulation 10-100 billion CFU daily B 5 L-Glutamine Gut health & muscle recovery 5-15g A 5 Iron Bisglycinate Gentle high-absorption iron 18-65 mg elemental A 6 Vitamin C (Liposomal) Maximum absorption vitamin C 1000-3000 mg B 5 Bacillus coagulans IBS relief & protein absorption 1-2 billion CFU A 6 Apple Cider Vinegar Blood sugar & digestive support 1-2 tablespoons diluted B 5 Digestive Enzymes Digestive support & nutrient absorption 1-2 capsules per meal A 5 Bifidobacterium infantis IBS relief & gut inflammation 1-20 billion CFU A 6 Lactobacillus paracasei Immune support & allergy management 1-10 billion CFU A 6 Lactobacillus reuteri Digestive health & bone support 1-10 billion CFU A 6 Peppermint Oil IBS & digestive spasm relief 0.2-0.6ml A 5 Calcium Citrate Superior absorption bone & heart health 500-1200 mg A 6 Bacillus clausii Antibiotic protection & immune support 2-4 billion CFU A 6 Bifidobacterium breve Immune balance & allergy prevention 1-20 billion CFU A 6 Lactobacillus helveticus Stress reduction & cardiovascular support 1-10 billion CFU A 6 Pancreatin Complete digestive enzyme replacement 25,000-150,000 units lipase daily A 6 Aloe Vera Digestive healing & soothing 50-300mg B 5 Ghee Extract Digestive health & traditional wellness 5-10ml B 5 Lactobacillus bulgaricus Lactose digestion & yogurt benefits Through yogurt consumption B 6 Spore-forming probiotics Comprehensive stability & multi-target support 1-5 billion CFU B 6 Bacillus subtilis Digestive enzymes & cardiovascular support 1-3 billion CFU B 6 Fennel Digestive comfort & gas relief 100-600mg B 5 Beta-Glucan Cholesterol reduction & immune support 3-10 g (oat) or 250-500 mg (mushroom) A 6 Clostridium butyricum Butyrate production & gut barrier support 1-3 billion CFU B 6 Psyllium Husk Digestive health & cholesterol support 5-15g A 5 Slippery Elm Digestive protection & soothing 400-800mg B 5 Digestive yeasts Digestive enzyme support & gut balance 1-2 capsules C 6 Chloride Electrolyte & digestive support 2300mg A 5 Bone Broth Collagen Gut healing & collagen support 20-40g powder B 5 Inulin Gut health & prebiotic support 5-20 g A 6 Serrapeptase Systemic anti-inflammatory 10,000-60,000 SPU daily B 5 Betaine HCl Stomach acid support 200-600mg with meals B 5 Marshmallow Root Digestive & respiratory soothing 500-1000mg B 5 L-Threonine Immune & digestive support 500-1500mg A 5 Kefir yeasts Fermentation support & gut health 1-2 capsules C 6 Pepsin Enzyme Protein digestion support 200-600mg with meals B 5 Wild Yam Traditional women's wellness & digestive comfort 425-850mg C 4 Bromelain Digestive enzyme & anti-inflammatory 500-3000mg B 5 Cellulase Plant fiber digestion 500-2,000 CU with meals B 5 Digestive Bitters Digestive stimulation 1/4 to 1/2 teaspoon B 5 Pectin Cholesterol support & digestive health 5-20 g B 6 Superoxide Dismutase (SOD) Free radical neutralization 250-750 IU daily A 5 Zinc Carnosine Gastric protection & healing 75-150mg twice daily A 5 Catalase H2O2 neutralization 5,000-15,000 units daily A 5 Ox Bile Fat digestion & bile acid support 500-1,500 mg with meals B 6 Glutathione Peroxidase (GPx) Membrane lipid protection Support via 200-400mcg selenium A 5 Lumbrokinase Ultra-potent circulation support 20-60mg daily B 5

Common questions

What are the best supplements for digestion?

By usage and evidence: Lactase, Lactobacillus acidophilus, Protease. 42 compounds here carry evidence level A, meaning the effect was studied directly rather than inferred.

How many supplements for digestion can you take at once?

There is no fixed limit, but every added compound multiplies possible interactions. The compounds on this page have 394 documented interactions between them — check a pair before stacking it.

How long until supplements for digestion start working?

Depends on the compound. Each page lists first effects and peak benefit windows separately, because the two differ by weeks for most compounds.