Supplements for Digestion

Digestion: 75 compounds are used here, 44 of them at evidence level A. The most used is Lactase. Between them there are 415 documented interactions — which is why the order and timing of a stack matters as much as the choice.

0 compounds

0 interactions

0 evidence A

Where the evidence is strongest

Ranked by popularity, with what each one actually does

Lactase

Lactose digestion & dairy tolerance

3,000-9,000 ALU units With dairy consumption Evidence A 95% absorbed

Lactobacillus acidophilus

Lactose tolerance & vaginal health

1-20 billion CFU With meals especially dairy Evidence A 85% absorbed

Protease

Protein digestion & amino acid absorption

20,000-60,000 HUT units With protein rich meals Evidence A 85% absorbed

Lactobacillus rhamnosus

Immune support & antibiotic protection

1-20 billion CFU With meals or during antibiotics Evidence A 90% absorbed

Lipase

Fat digestion & absorption

5,000-25,000 FIP units With fatty meals Evidence A 90% absorbed

What these are, chemically

7 types

Probiotics 24 Enzymes 13 Compounds 11 Minerals 9 Botanicals 7 Fatty Acids 4 Blends & Formulas 3

Choosing between forms

Same compound, different absorption

Lactobacillus acidophilus vs Lactobacillus rhamnosus 85% · 90% Bifidobacterium lactis vs Lactobacillus acidophilus 85% · 85% Lactobacillus acidophilus vs Saccharomyces boulardii 85% · 80% Bifidobacterium longum vs Lactobacillus acidophilus 85% · 85% Lactobacillus acidophilus vs Lactobacillus casei 85% · 85% Bifidobacterium lactis vs Lactobacillus rhamnosus 85% · 90% Lactobacillus rhamnosus vs Saccharomyces boulardii 90% · 80% Bifidobacterium longum vs Lactobacillus rhamnosus 85% · 90%

All 75 compounds

dose · evidence · documented interactions

Lactase Lactose digestion & dairy tolerance 3,000-9,000 ALU units A 6 Lactobacillus acidophilus Lactose tolerance & vaginal health 1-20 billion CFU A 6 Protease Protein digestion & amino acid absorption 20,000-60,000 HUT units A 6 Lactobacillus rhamnosus Immune support & antibiotic protection 1-20 billion CFU A 6 Lipase Fat digestion & absorption 5,000-25,000 FIP units A 6 Amylase Carbohydrate digestion & starch breakdown 5,000-20,000 SKB units A 6 Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 5 Bifidobacterium lactis Digestive regularity & lactose tolerance 1-20 billion CFU A 6 Papain Protein digestion & anti-inflammatory support 500-1,500 mg B 6 Ginger Digestive health & anti-nausea 250-1000mg A 5 Magnesium Citrate Balanced absorption & digestive support 300-600 mg A 5 Saccharomyces boulardii Antibiotic protection & pathogen resistance 250-500mg A 6 Avocado Oil Heart health & nutrient absorption 15-30ml B 5 Bifidobacterium longum Digestive & immune health 1-20 billion CFU A 6 Iron Fumarate Gentle iron with good absorption 65-130 mg A 6 Krill Oil Superior omega-3 absorption & cardiovascular health 500-1,500 mg B 6 Lactobacillus casei Digestive health & immune support 1-20 billion CFU A 6 Bifidobacterium animalis Digestive regularity & immune support 1-20 billion CFU A 6 Multi-Strain Probiotic Digestive & immune health 10-50 billion CFU A 6 Zinc Citrate Balanced absorption daily zinc 15-25 mg A 6 Bifidobacterium bifidum Digestive & women's health 1-20 billion CFU A 6 Lactobacillus plantarum IBS relief & nutrient absorption 5-20 billion CFU A 6 Saccharomyces cerevisiae Nutritional support & B vitamins 1-2 tablespoons B 6 Zinc Bisglycinate Superior absorption immune support 15-25 mg A 6 Bacillus coagulans IBS relief & protein absorption 1-2 billion CFU A 6 Iron Bisglycinate Gentle high-absorption iron 18-65 mg elemental A 6 L-Glutamine Gut health & muscle recovery 5-15g A 5 Probiotics for Autoimmune Disease Support Gut health & immune modulation 10-100 billion CFU daily B 5 Vitamin C (Liposomal) Maximum absorption vitamin C 1000-3000 mg B 5 Apple Cider Vinegar Blood sugar & digestive support 1-2 tablespoons diluted B 5 Bifidobacterium infantis IBS relief & gut inflammation 1-20 billion CFU A 6 Digestive Enzymes Digestive support & nutrient absorption 1-2 capsules per meal A 5 Lactobacillus paracasei Immune support & allergy management 1-10 billion CFU A 6 Prebiotic Fiber Complex Microbiome support 5-15g daily A 5 Lactobacillus reuteri Digestive health & bone support 1-10 billion CFU A 6 Peppermint Oil IBS & digestive spasm relief 0.2-0.6ml A 5 Bacillus clausii Antibiotic protection & immune support 2-4 billion CFU A 6 Bifidobacterium breve Immune balance & allergy prevention 1-20 billion CFU A 6 Calcium Citrate Superior absorption bone & heart health 500-1200 mg A 6 Lactobacillus helveticus Stress reduction & cardiovascular support 1-10 billion CFU A 6 Aloe Vera Digestive healing & soothing 50-300mg B 5 Digestive Enzymes Complex Complete food digestion 1-3 capsules with meals A 5 Ghee Extract Digestive health & traditional wellness 5-10ml B 5 Lactobacillus bulgaricus Lactose digestion & yogurt benefits Through yogurt consumption B 6 Pancreatin Complete digestive enzyme replacement 25,000-150,000 units lipase daily A 6 Spore-forming probiotics Comprehensive stability & multi-target support 1-5 billion CFU B 6 Bacillus subtilis Digestive enzymes & cardiovascular support 1-3 billion CFU B 6 Fennel Digestive comfort & gas relief 100-600mg B 5 Beta-Glucan Cholesterol reduction & immune support 3-10 g (oat) or 250-500 mg (mushroom) A 6 Clostridium butyricum Butyrate production & gut barrier support 1-3 billion CFU B 6 Psyllium Husk Digestive health & cholesterol support 5-15g A 5 Butter Oil Gut health & nutrient absorption 5-10ml B 5 Digestive yeasts Digestive enzyme support & gut balance 1-2 capsules C 6 Slippery Elm Digestive protection & soothing 400-800mg B 5 Betaine HCl Stomach acid support 200-600mg with meals B 5 Bone Broth Collagen Gut healing & collagen support 20-40g powder B 5 Chloride Electrolyte & digestive support 2300mg A 5 Inulin Gut health & prebiotic support 5-20 g A 6 Marshmallow Root Digestive & respiratory soothing 500-1000mg B 5 Serrapeptase Systemic anti-inflammatory 10,000-60,000 SPU daily B 5 L-Threonine Immune & digestive support 500-1500mg A 5 Gut Healing Herbs Complex Gut healing & inflammation relief 2-4 capsules daily B 5 Kefir yeasts Fermentation support & gut health 1-2 capsules C 6 Pepsin Enzyme Protein digestion support 200-600mg with meals B 5 Wild Yam Traditional women's wellness & digestive comfort 425-850mg C 5 Bromelain Digestive enzyme & anti-inflammatory 500-3000mg B 5 Cellulase Plant fiber digestion 500-2,000 CU with meals B 5 Digestive Bitters Digestive stimulation 1/4 to 1/2 teaspoon B 5 Pectin Cholesterol support & digestive health 5-20 g B 6 Superoxide Dismutase (SOD) Free radical neutralization 250-750 IU daily A 5 Catalase H2O2 neutralization 5,000-15,000 units daily A 5 Ox Bile Fat digestion & bile acid support 500-1,500 mg with meals B 6 Zinc Carnosine Gastric protection & healing 75-150mg twice daily A 5 Glutathione Peroxidase (GPx) Membrane lipid protection Support via 200-400mcg selenium A 5 Lumbrokinase Ultra-potent circulation support 20-60mg daily B 5

Common questions

What are the best supplements for digestion?

By usage and evidence: Lactase, Lactobacillus acidophilus, Protease. 44 compounds here carry evidence level A, meaning the effect was studied directly rather than inferred.

How many supplements for digestion can you take at once?

There is no fixed limit, but every added compound multiplies possible interactions. The compounds on this page have 415 documented interactions between them — check a pair before stacking it.

How long until supplements for digestion start working?

Depends on the compound. Each page lists first effects and peak benefit windows separately, because the two differ by weeks for most compounds.