Zinc Bisglycinate

Premium chelated zinc form bound to glycine amino acids for superior absorption, bioavailability, and minimal digestive upset

Scientific nameZinc Bisglycinate Chelate FormulaC4H8N2O4Zn Molecular weight213.51 g/mol CAS14281-83-5

85 absorption score

9 safety / 10

35 USD per month

30 elemental zinc %

6 documented interactions

Check it against something

Evidence level A

Zinc Bisglycinate with:

99 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Superior bioavailability and absorption

Up to 3x better absorbed than zinc sulfate or oxide

Glycine chelation protects zinc from interference and enhances uptake Evidence A-grade 1-2 weeks

Excellent digestive tolerance

Minimal nausea or stomach upset compared to other zinc forms

Chelation prevents zinc from causing gastric irritation Evidence A-grade Immediate

Enhanced immune system support

Optimizes immune function and reduces infection risk

Zinc essential for immune cell development and function Evidence A-grade 2-4 weeks

Improved wound healing and skin health

Accelerates tissue repair and maintains healthy skin

Zinc cofactor for collagen synthesis and tissue regeneration Evidence A-grade 2-6 weeks

Better zinc status maintenance

More effective at correcting and preventing zinc deficiency

Superior absorption leads to better tissue zinc levels Evidence A-grade 4-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Probiotics for Autoimmune Disease Support Gut health & immune modulation 10-100 billion CFU daily B 60% Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 90% Vitamin D3 Bone health & immune support 1000-2000 IU A 85% Magnesium Citrate Balanced absorption & digestive support 300-600 mg A 35% Chloride Electrolyte & digestive support 2300mg A 95% Bone Broth Collagen Gut healing & collagen support 20-40g powder B 85%

Or a different form of the same thing

the comparison people search most

Zinc Bisglycinate vs Zinc Picolinate absorption 85 against 95 · $35 against $20 a month 95% Zinc Bisglycinate vs Zinc Gluconate absorption 85 against 60 · $35 against $20 a month 60% Zinc Bisglycinate vs Zinc Carnosine absorption 85 against 85 · $35 against $35 a month 85% Zinc Bisglycinate vs Zinc Citrate absorption 85 against 70 · $35 against $25 a month 70%

All Zinc forms ranked by absorption →

Every pair we checked

12 combinations scored by the engine

Zinc Bisglycinate + Copper Bisglycinate High zinc doses can reduce copper absorption Needs attention 22

Zinc Bisglycinate + Iron Sulfate Very high iron doses may compete with zinc Needs attention 58

Zinc Bisglycinate + Calcium Carbonate Very high calcium may interfere with zinc absorption Needs attention 58

Zinc Bisglycinate + Caffeine No documented interaction either way No known interaction 70

Zinc Bisglycinate + Creatine Monohydrate No documented interaction either way No known interaction 70

Zinc Bisglycinate + Lactase No documented interaction either way No known interaction 70

Zinc Bisglycinate + Bovine Collagen No documented interaction either way No known interaction 70

Zinc Bisglycinate + DHA No documented interaction either way No known interaction 70

Zinc Bisglycinate + Turmeric No documented interaction either way No known interaction 70

Zinc Bisglycinate + Whey Protein Protein enhances zinc absorption and utilization Works better together 82

Zinc Bisglycinate + Vitamin D3 Zinc required for vitamin A metabolism and transport Works better together 94

Zinc Bisglycinate + Vitamin C (Ascorbic Acid) Zinc required for vitamin A metabolism and transport Works better together 94

Dosage

With or without food

Daily15-25 mg

Maintenance10-15 mg daily

Therapeutic20-40 mg daily

Immune support15-25 mg daily

Elemental zincContains ~23% elemental zinc

Upper limit 40 mg NIH ODS

Before you take it

VeganYes

When to expect it

First Effects1-2 weeks for immune and energy improvements

Peak Benefits4-12 weeks for optimal zinc status and health benefits

Deficiency DevelopmentWeeks to months with inadequate intake

Toxicity OnsetRare with recommended doses, possible with excessive intake

How to measure it

$40-80

MarkerSerum zinc, plasma zinc, or RBC zinc

OptimalSerum: 70-120 μg/dL, Plasma: 80-120 μg/dL

Deficient belowSerum: <70 μg/dL

FrequencyEvery 6-12 months if supplementing regularly

What people actually reported to the FDA

CAERS, 517 reports naming it as the suspect

Most reported effects

Cough 44

Malaise 40

Vomiting 40

Nausea 38

Dyspnoea 36

Excluded from the list above: choking (76). Those are people struggling with the tablet itself, not with the compound.

Named as the suspect 517 reports of 964 that mention it at all

Serious outcome 87% hospitalisation, emergency room or worse

Other Serious or Important Medical Event398

Hospitalization81

Visited a Health Care Provider71

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Elemental zinc 30.6% of 213.51 g/mol

Absorption Very high 85 of 100 · best absorbed form of this compound

Delivered daily 5.2 mg

Cost per 100 mg delivered $22.43 comparative — uses the absorption score, not a measured percentage

A 500 mg capsule of Zinc Bisglycinate contains 153 mg of zinc. How much of that crosses into your blood is not measured for this form — the absorption score ranks it against other forms, it is not a share of the dose. How this is calculated →

Works better with

3 documented

Vitamin A

Zinc required for vitamin A metabolism and transport

Zinc needed for retinol-binding protein synthesis · level A

Vitamin D

Both support immune function synergistically

Complementary roles in immune cell function · level A

Protein

Protein enhances zinc absorption and utilization

Amino acids from protein support zinc transport · level A

What not to take with Zinc Bisglycinate

3 documented

Copper

High zinc doses can reduce copper absorption

Competition for absorption transporters · moderate significance

Iron High Dose

Very high iron doses may compete with zinc

Mineral competition for absorption pathways · mild significance

Calcium High Dose

Very high calcium may interfere with zinc absorption

Potential mineral competition · mild significance

Medication interactions

Discuss these with a pharmacist before combining

antibiotics-tetracycline-quinolones Major

Zinc reduces antibiotic absorption

What to do: Space doses 2-4 hours apart

penicillamine Major

Zinc reduces penicillamine effectiveness

What to do: Space doses 2+ hours apart

thiazide-diuretics Minor

Diuretics may increase zinc loss

What to do: Monitor zinc status with long-term diuretic use

Available forms

bioavailability compared

Ranks 2 of 5 among zinc forms. Zinc Picolinate absorbs better — 95%. Compare all forms →

Zinc Bisglycinate Chelate 85

Zinc Bisglycinate Chelate: Superior absorption, Gentle on stomach, High bioavailability, Excellent tolerance

Food sources

before you supplement

Zinc bisglycinate not found in foods Only available as supplement · 85

Oysters (natural zinc) 74 mg per 6 medium oysters · 50

Red meat (natural zinc) 4-8 mg per 3 oz serving · 40

Pumpkin seeds (natural zinc) 2-3 mg per ounce · 25

Too little

deficiency signs

Frequent infections and poor immune function
Slow wound healing and poor skin health
Hair loss and brittle nails
Loss of taste and smell
Growth retardation in children
Poor appetite and weight loss
Delayed sexual maturation

Too much

toxicity signs

Copper deficiency with long-term high doses
Nausea and vomiting (rare with chelated form)
Reduced immune function (paradoxically)
Interference with iron absorption
Generally excellent safety profile

Who benefits most

immune-support-seekers

Superior form for optimal immune system function

15-25 mg daily

digestive-sensitive-individuals

Best tolerated zinc form with minimal stomach upset

10-20 mg daily

zinc-deficiency-correction

Most effective form for correcting zinc deficiency

25-40 mg daily

wound-healing-skin-health

Optimal zinc form for tissue repair and skin health

20-30 mg daily

premium-supplement-users

Highest quality zinc form for those wanting the best

15-25 mg daily

Where to buy it

compare forms first

Look for Zinc Bisglycinate at 15-25 mg per serving. The form that matters here is Zinc Bisglycinate Chelate.

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How it works

Chelation with glycine protects zinc from absorption inhibitors
Amino acid transporters facilitate superior intestinal uptake
Bypasses competition with other minerals for absorption
Glycine component may enhance zinc utilization
Stable chelate structure survives gastric acid
Enhanced bioavailability leads to better tissue zinc levels

Key findings

what the evidence supports

Superior bioavailability compared to zinc sulfate and oxide forms
Excellent tolerance with minimal digestive side effects
Effective for correcting zinc deficiency and supporting immune function
Preferred form for long-term supplementation

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Zinc Bisglycinate?

Documented effects: Superior bioavailability and absorption; Excellent digestive tolerance; Enhanced immune system support; Improved wound healing and skin health. Up to 3x better absorbed than zinc sulfate or oxide

How much Zinc Bisglycinate should you take per day?

The common daily range is 15-25 mg. By goal — maintenance: 10-15 mg daily; therapeutic: 20-40 mg daily; immune support: 15-25 mg daily; elemental zinc: Contains ~23% elemental zinc.

When is the best time to take Zinc Bisglycinate?

With or without food. First effects are typically reported within 1-2 weeks for immune and energy improvements.

What are the side effects of Zinc Bisglycinate?

At excessive doses: Copper deficiency with long-term high doses, Nausea and vomiting (rare with chelated form), Reduced immune function (paradoxically), Interference with iron absorption, Generally excellent safety profile. Safety rating at normal doses is 9 out of 10.

What should you not take with Zinc Bisglycinate?

Separate it from Copper, Iron High Dose, Calcium High Dose by two to four hours. High zinc doses can reduce copper absorption

Does Zinc Bisglycinate interact with medications?

Documented interactions with antibiotics-tetracycline-quinolones, penicillamine, thiazide-diuretics. Discuss these with a pharmacist before combining.

How much Zinc Bisglycinate is too much?

The tolerable upper intake level is 40 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: Copper deficiency with long-term high doses, Nausea and vomiting (rare with chelated form), Reduced immune function (paradoxically).

How do you know if you need Zinc Bisglycinate?

The marker is Serum zinc, plasma zinc, or RBC zinc, optimal range Serum: 70-120 μg/dL, Plasma: 80-120 μg/dL. Common deficiency signs: Frequent infections and poor immune function, Slow wound healing and poor skin health, Hair loss and brittle nails, Loss of taste and smell.

Taken for

59 Immunity

Vitamin D3 · Vitamin C (Ascorbic Acid) · Comprehensive Immune Support Complex

74 Digestion

Lactase · Lactobacillus acidophilus · Protease