Superior fibrinolytic and clot-dissolving activity
Most potent fibrinolytic enzyme, stronger than nattokinase
Lumbrokinase
Potent fibrinolytic enzyme complex derived from earthworms with cardiovascular and circulation benefits
Scientific nameEarthworm fibrinolytic enzyme complex
FormulaMultiple proteolytic enzymes
Molecular weight24-28 kDa g/mol
85
absorption score
2
safety / 10
80
USD per month
5
documented interactions
Check it against something
Lumbrokinase with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Vitamin E (Gamma-Tocopherol)
- Whey Protein
- Zinc Gluconate
Nothing found
63
out of 100
Needs attention
Separate by 2-4 hours to avoid the interaction below.
What it does
mechanism and evidence for each claimEnhanced cardiovascular circulation
Dramatically improves blood flow and reduces cardiovascular risk
Advanced stroke and heart attack prevention
May help prevent thrombotic cardiovascular events
Improved oxygen and nutrient delivery
Enhanced circulation delivers more oxygen to all tissues
Support for peripheral circulation
Improves circulation to extremities and organs
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Probiotics for Autoimmune Disease Support
Gut health & immune modulation
10-100 billion CFU daily
B
60%
Magnesium Glycinate
Superior absorption sleep & muscle support
200-600 mg
A
90%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Magnesium Citrate
Balanced absorption & digestive support
300-600 mg
A
35%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
Chloride
Electrolyte & digestive support
2300mg
A
95%
Every pair we checked
12 combinations scored by the engine
Lumbrokinase + Vitamin D3
May partially counteract fibrinolytic effects
Needs attention
63
Lumbrokinase + Vitamin C (Ascorbic Acid)
May partially counteract fibrinolytic effects
Needs attention
63
Lumbrokinase + Caffeine
No documented interaction either way
No known interaction
70
Lumbrokinase + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Lumbrokinase + Calcium Carbonate
No documented interaction either way
No known interaction
70
Lumbrokinase + Whey Protein
No documented interaction either way
No known interaction
70
Lumbrokinase + Lactase
No documented interaction either way
No known interaction
70
Lumbrokinase + Bovine Collagen
No documented interaction either way
No known interaction
70
Lumbrokinase + DHA
No documented interaction either way
No known interaction
70
Lumbrokinase + Turmeric
No documented interaction either way
No known interaction
70
Lumbrokinase + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced cardiovascular protection but increased bleeding risk
Works better together
75
Lumbrokinase + Coenzyme Q10 (CoQ10)
Cardiovascular support without bleeding interaction
Works better together
75
Dosage
Daily20-60mg daily
Cardiovascular prevention10-20mg daily under medical supervision
Circulation enhancement20-40mg daily with monitoring
Therapeutic use40-60mg daily under strict medical oversight
MaximumDo not exceed 60mg daily, requires continuous medical monitoring
When to expect it
First Effects1-2 hours for initial fibrinolytic activity
Peak Benefits4-8 weeks for optimal cardiovascular circulation benefits
Deficiency DevelopmentNot applicable - therapeutic enzyme
Toxicity OnsetBleeding complications can occur rapidly with inappropriate use
How to measure it
MarkerComprehensive clotting panel (PT/INR, aPTT, fibrinogen, D-dimer, platelet function)
OptimalImproved circulation markers with normal clotting function
Deficient belowNot applicable for therapeutic enzyme
FrequencyBaseline assessment required, weekly monitoring during initial use, monthly ongoing
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 85 of 100 · best absorbed form of this compound
Delivered daily
34 mg
Cost per 100 mg delivered
$7.84 comparative — uses the absorption score, not a measured percentage
Works better with
+
Omega 3 Fatty Acids
Enhanced cardiovascular protection but increased bleeding risk
Complementary cardiovascular mechanisms but additive bleeding risk · level C
+
Vitamin E
Antioxidant protection but potential bleeding enhancement
Antioxidant benefits but may enhance anticoagulant effects · level C
+
Coq10
Cardiovascular support without bleeding interaction
Heart health support through different mechanism · level CWhat not to take with Lumbrokinase
!
Blood Thinning Medications
Extremely dangerous additive anticoagulant effects
Both prevent clotting leading to severe bleeding risk · contraindicated significance
!
Vitamin K
May partially counteract fibrinolytic effects
Vitamin K promotes clotting while lumbrokinase prevents it · high significanceMedication interactions
Discuss these with a pharmacist before combiningLife-threatening interaction - absolutely contraindicated
What to do: Never use together under any circumstances
Extremely dangerous bleeding risk
What to do: Absolutely avoid concurrent use
Severe bleeding risk
What to do: Do not use together
Available forms
Standardized Lumbrokinase Extract: Extremely potent, Superior fibrinolytic activity, Cardiovascular benefits, Traditional use
Food sources
Earthworm extract (traditional)
Traditional Chinese medicine preparation · 70
Lumbrokinase supplements
Concentrated enzyme activity (LU units) · 85
Not found in conventional foods
Must be obtained through specialized supplementation · N/A
Too little
- Not applicable (therapeutic enzyme, not essential nutrient):
- Conditions addressed by lumbrokinase:
- Severe circulation problems and thrombotic risk
- High cardiovascular disease risk
- Poor tissue perfusion and oxygenation
- Increased risk of stroke and heart attack
- Peripheral circulation disorders
Too much
- Extremely high bleeding risk - primary concern:
- Severe bleeding or hemorrhage
- Prolonged bleeding from any injury
- Internal bleeding (black stools, severe headache)
- Unusual bleeding (nosebleeds, gum bleeding)
- Signs of stroke from bleeding complications
Who benefits most
high-cardiovascular-risk
Potent prevention of thrombotic cardiovascular events
20-40mg daily under strict medical supervision
severe-circulation-problems
Most potent option for serious circulation issues
20-60mg daily with medical monitoring
post-stroke-prevention
May help prevent recurrent thrombotic strokes
20-40mg daily under medical supervision
advanced-age-circulation
Supports healthy aging of cardiovascular system
10-20mg daily with medical oversight
travel-related-clot-prevention
Prevention of travel-related thrombosis
20mg before and during extended travelWhere to buy it
Look for Lumbrokinase at 20-60mg daily per serving. The form that matters here is Standardized Lumbrokinase Extract.
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How it works
- Multiple fibrinolytic enzymes dissolve fibrin clots with extreme potency
- Activates plasminogen to plasmin enhancing natural clot dissolution
- Dramatically reduces blood viscosity and improves flow characteristics
- Improves endothelial function and arterial compliance
- Dissolves microthrombi and improves capillary circulation
- Prevents platelet aggregation and clot formation
Key findings
what the evidence supports- Extremely potent fibrinolytic enzyme with superior cardiovascular benefits
- Most effective for circulation improvement and clot prevention
- Requires strict medical supervision due to very high bleeding risk
- Should only be used under continuous medical monitoring
Sources: NIH Examine.com · data reviewed 2026-08-01
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Lumbrokinase?
Documented effects: Superior fibrinolytic and clot-dissolving activity; Enhanced cardiovascular circulation; Advanced stroke and heart attack prevention; Improved oxygen and nutrient delivery. Most potent fibrinolytic enzyme, stronger than nattokinase
How much Lumbrokinase should you take per day?
The common daily range is 20-60mg daily. By goal — cardiovascular prevention: 10-20mg daily under medical supervision; circulation enhancement: 20-40mg daily with monitoring; therapeutic use: 40-60mg daily under strict medical oversight; maximum: Do not exceed 60mg daily, requires continuous medical monitoring.
When is the best time to take Lumbrokinase?
Empty stomach. First effects are typically reported within 1-2 hours for initial fibrinolytic activity.
What are the side effects of Lumbrokinase?
At excessive doses: Extremely high bleeding risk - primary concern:, Severe bleeding or hemorrhage, Prolonged bleeding from any injury, Internal bleeding (black stools, severe headache), Unusual bleeding (nosebleeds, gum bleeding). Safety rating at normal doses is 2 out of 10.
What should you not take with Lumbrokinase?
Separate it from Blood Thinning Medications, Vitamin K by two to four hours. Extremely dangerous additive anticoagulant effects
Does Lumbrokinase interact with medications?
Documented interactions with warfarin, aspirin, clopidogrel. Discuss these with a pharmacist before combining.
How do you know if you need Lumbrokinase?
The marker is Comprehensive clotting panel (PT/INR, aPTT, fibrinogen, D-dimer, platelet function), optimal range Improved circulation markers with normal clotting function. Common deficiency signs: Not applicable (therapeutic enzyme, not essential nutrient):, Conditions addressed by lumbrokinase:, Severe circulation problems and thrombotic risk, High cardiovascular disease risk.