Primary free radical neutralization
Converts harmful superoxide radicals into harmless hydrogen peroxide and oxygen
Superoxide Dismutase (SOD)
Primary antioxidant enzyme that neutralizes superoxide radicals and protects cells from oxidative damage
Scientific nameSuperoxide dismutase enzyme
FormulaMetalloenzyme protein
Molecular weight32-34 kDa g/mol
CAS9054-89-1
60
absorption score
9
safety / 10
45
USD per month
5
documented interactions
Check it against something
Superoxide Dismutase (SOD) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Catalase
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
94
out of 100
Works better together
Take together — same timing window amplifies the synergy.
What it does
mechanism and evidence for each claimEnhanced cellular longevity
Protects cells from oxidative damage that accelerates aging
Improved mitochondrial function
Protects mitochondria from oxidative stress and energy decline
Reduced inflammation
Decreases inflammatory responses by neutralizing inflammatory radicals
Enhanced exercise recovery
Reduces exercise-induced oxidative stress and muscle damage
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Probiotics for Autoimmune Disease Support
Gut health & immune modulation
10-100 billion CFU daily
B
60%
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Magnesium Glycinate
Superior absorption sleep & muscle support
200-600 mg
A
90%
Magnesium Citrate
Balanced absorption & digestive support
300-600 mg
A
35%
Chloride
Electrolyte & digestive support
2300mg
A
95%
Bone Broth Collagen
Gut healing & collagen support
20-40g powder
B
85%
Every pair we checked
12 combinations scored by the engine
Superoxide Dismutase (SOD) + Caffeine
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Calcium Carbonate
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Whey Protein
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Lactase
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Bovine Collagen
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + DHA
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Turmeric
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Superoxide Dismutase (SOD) + Vitamin D3
Enhanced overall antioxidant protection
Works better together
78
Superoxide Dismutase (SOD) + Glutathione
Comprehensive antioxidant enzyme defense system
Works better together
82
Superoxide Dismutase (SOD) + Catalase
Complete antioxidant enzyme system for cellular protection
Works better together
94
Dosage
Daily250-750 IU daily
Antioxidant support250-500 IU daily
Therapeutic500-1000 IU daily
Athletic performance750-1000 IU daily around training
MaximumFollow product guidelines, typically not more than 1000 IU daily
When to expect it
First EffectsImmediate cellular protection upon absorption
Peak Benefits8-12 weeks for optimal antioxidant status and cellular protection
Deficiency DevelopmentGradual decline with age and oxidative stress
Toxicity OnsetRare, mainly from excessive supplementation
How to measure it
MarkerSOD activity levels, oxidative stress markers, inflammatory markers
OptimalNormal to high SOD activity, low oxidative stress
Deficient belowReduced SOD activity, elevated oxidative stress markers
FrequencyBaseline and periodic monitoring during supplementation
What people actually reported to the FDA
CAERS, 2 reports naming it as the suspectMost reported effects
Named as the suspect
2 reports
of 2 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Other Serious Outcome2
Hospitalization1
Other Serious or Important Medical Event1
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
Works better with
+
Catalase
Complete antioxidant enzyme system for cellular protection
Catalase breaks down H2O2 produced by SOD reaction · level A
+
Glutathione Peroxidase
Comprehensive antioxidant enzyme defense system
Complementary antioxidant enzymes work together · level A
+
Vitamin C
Enhanced overall antioxidant protection
Vitamin C regenerates and supports enzyme function · level BWhat not to take with Superoxide Dismutase (SOD)
!
Excessive Iron
May promote oxidative stress and reduce SOD effectiveness
Iron catalyzes formation of hydroxyl radicals · moderate significance
!
Alcohol Excess
Increases oxidative stress and depletes antioxidant enzymes
Alcohol metabolism generates reactive oxygen species · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay interfere with oxidative mechanisms of some treatments
What to do: Consult oncologist before use during treatment
May enhance immune function
What to do: Monitor immune status if using both
Theoretical interaction through improved vascular health
What to do: Monitor if using anticoagulants
Available forms
GliSODin (Gliadin-Protected SOD): High bioavailability, Protected from digestion, Clinically studied, Optimal absorption
Food sources
Organ meats (liver, kidney)
High natural SOD activity · 40
Green vegetables (broccoli, spinach)
Moderate SOD activity · 35
Melons and stone fruits
Natural SOD content · 30
GliSODin supplements
Concentrated, protected SOD enzyme · 85
Too little
- Accelerated cellular aging and damage:
- Increased susceptibility to oxidative stress
- Poor exercise recovery and muscle damage
- Accelerated aging processes
- Increased inflammation and tissue damage
- Mitochondrial dysfunction and energy decline
- Higher risk of degenerative diseases
Too much
- Generally very safe but potential concerns:
- Allergic reactions to bovine-derived forms
- Digestive upset with poor-quality products
- Theoretical interference with beneficial oxidative signaling
- Reduced effectiveness due to poor bioavailability
Who benefits most
aging-adults
Age-related decline in natural SOD production
250-500 IU daily with bioavailable forms
high-oxidative-stress
Enhanced protection against environmental and lifestyle stressors
500-1000 IU daily
athletes-intense-training
Reduces exercise-induced oxidative damage and improves recovery
500-750 IU daily, especially around training
chronic-inflammatory-conditions
Helps reduce oxidative stress component of inflammation
250-750 IU daily
longevity-anti-aging
Supports healthy aging by protecting against cellular damage
250-500 IU daily long-termWhere to buy it
Look for Superoxide Dismutase (SOD) at 250-750 IU daily per serving. The form that matters here is GliSODin (Gliadin-Protected SOD).
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What else affects it
Beyond other supplements
!
Excessive iron
May promote oxidative stress and reduce SOD effectiveness
Iron catalyzes formation of hydroxyl radicals
!
Alcohol excess
Increases oxidative stress and depletes antioxidant enzymes
Alcohol metabolism generates reactive oxygen speciesHow it works
- Catalyzes dismutation of superoxide radicals (2O2- + 2H+ → H2O2 + O2)
- Cu/Zn-SOD protects cytoplasm and nucleus from oxidative damage
- Mn-SOD specifically protects mitochondria from superoxide damage
- Prevents superoxide from forming more damaging peroxynitrite radicals
- Works synergistically with catalase and glutathione peroxidase
- Maintains cellular redox balance and prevents oxidative chain reactions
Key findings
what the evidence supports- Essential enzyme for cellular protection and healthy aging
- Bioavailability is crucial - protected forms like GliSODin most effective
- Generally very safe with minimal side effects
- Most beneficial when combined with other antioxidant enzymes
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Superoxide Dismutase (SOD)?
Documented effects: Primary free radical neutralization; Enhanced cellular longevity; Improved mitochondrial function; Reduced inflammation. Converts harmful superoxide radicals into harmless hydrogen peroxide and oxygen
How much Superoxide Dismutase (SOD) should you take per day?
The common daily range is 250-750 IU daily. By goal — antioxidant support: 250-500 IU daily; therapeutic: 500-1000 IU daily; athletic performance: 750-1000 IU daily around training; maximum: Follow product guidelines, typically not more than 1000 IU daily.
When is the best time to take Superoxide Dismutase (SOD)?
With meals. First effects are typically reported within Immediate cellular protection upon absorption.
What are the side effects of Superoxide Dismutase (SOD)?
At excessive doses: Generally very safe but potential concerns:, Allergic reactions to bovine-derived forms, Digestive upset with poor-quality products, Theoretical interference with beneficial oxidative signaling, Reduced effectiveness due to poor bioavailability. Safety rating at normal doses is 9 out of 10.
What should you not take with Superoxide Dismutase (SOD)?
Separate it from Excessive Iron, Alcohol Excess by two to four hours. May promote oxidative stress and reduce SOD effectiveness
Does Superoxide Dismutase (SOD) interact with medications?
Documented interactions with chemotherapy, immunosuppressants, blood-thinners. Discuss these with a pharmacist before combining.
How do you know if you need Superoxide Dismutase (SOD)?
The marker is SOD activity levels, oxidative stress markers, inflammatory markers, optimal range Normal to high SOD activity, low oxidative stress. Common deficiency signs: Accelerated cellular aging and damage:, Increased susceptibility to oxidative stress, Poor exercise recovery and muscle damage, Accelerated aging processes.