Traditional women's hormonal support
Traditionally used for women's hormonal balance and comfort
Wild Yam
Traditional women's herb containing diosgenin, historically used for hormonal support and digestive comfort
Scientific nameDioscorea villosa
FormulaC27H42O3 (diosgenin)
Molecular weight414.63 g/mol
CAS512-04-9
55
absorption score
8
safety / 10
20
USD per month
4
documented interactions
Check it against something
Wild Yam with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
75
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimDigestive and antispasmodic support
Traditional relief from digestive discomfort and cramping
Menstrual comfort and PMS relief
Traditional support for menstrual comfort and PMS symptoms
Anti-inflammatory support
Provides natural anti-inflammatory benefits
Menopausal comfort support
Traditional support for menopausal transition comfort
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Probiotics for Autoimmune Disease Support
Gut health & immune modulation
10-100 billion CFU daily
B
60%
Melatonin
Sleep support & circadian rhythm
0.5-3mg
A
50%
Magnesium Glycinate
Superior absorption sleep & muscle support
200-600 mg
A
90%
Magnesium Citrate
Balanced absorption & digestive support
300-600 mg
A
35%
Chloride
Electrolyte & digestive support
2300mg
A
95%
Bone Broth Collagen
Gut healing & collagen support
20-40g powder
B
85%
Every pair we checked
12 combinations scored by the engine
Wild Yam + Caffeine
No documented interaction either way
No known interaction
70
Wild Yam + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Wild Yam + Vitamin D3
No documented interaction either way
No known interaction
70
Wild Yam + Calcium Carbonate
No documented interaction either way
No known interaction
70
Wild Yam + Whey Protein
No documented interaction either way
No known interaction
70
Wild Yam + Lactase
No documented interaction either way
No known interaction
70
Wild Yam + Bovine Collagen
No documented interaction either way
No known interaction
70
Wild Yam + DHA
No documented interaction either way
No known interaction
70
Wild Yam + Turmeric
No documented interaction either way
No known interaction
70
Wild Yam + Magnesium Oxide
Enhanced antispasmodic and muscle relaxation effects
Works better together
75
Wild Yam + Vitex (Chasteberry)
Comprehensive women's health and hormonal support
Works better together
75
Wild Yam + Ginger
Enhanced digestive comfort and anti-inflammatory support
Works better together
75
Dosage
Daily425-850mg
Digestive support425-850mg daily
Menstrual comfort425-850mg daily
Traditional wellness425mg daily
Anti inflammatory425mg daily
Before you take it
VeganYes
When to expect it
First Effects2-8 weeks for digestive and antispasmodic benefits
Peak Benefits8-16 weeks for sustained traditional women's health support
Deficiency DevelopmentNot applicable - herbal supplement
Toxicity OnsetRare, mainly digestive upset
How to measure it
MarkerBlood glucose if diabetic, general wellness markers
OptimalStable blood sugar, improved comfort symptoms
Deficient belowNot applicable for herbal supplement
FrequencyEvery 6-12 months for general wellness monitoring
What people actually reported to the FDA
CAERS, 3 reports naming it as the suspectMost reported effects
Named as the suspect
3 reports
of 9 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event2
Other Serious Outcome2
Hospitalization2
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Moderate 55 of 100 · middle of the range for this compound
Delivered daily
350.6 mg
Cost per 100 mg delivered
$0.19 comparative — uses the absorption score, not a measured percentage
Works better with
+
Magnesium
Enhanced antispasmodic and muscle relaxation effects
Both support muscle relaxation and reduce cramping · level C
+
Vitex Chasteberry
Comprehensive women's health and hormonal support
Complementary traditional women's herbs for hormonal wellness · level C
+
Ginger
Enhanced digestive comfort and anti-inflammatory support
Both provide digestive support and anti-inflammatory benefits · level CWhat not to take with Wild Yam
!
Unrealistic Hormone Expectations
Does not provide direct hormone replacement effects
Diosgenin does not convert to active hormones in humans · informational significanceMedication interactions
Discuss these with a pharmacist before combiningMay affect blood sugar levels
What to do: Monitor blood glucose
Generally safe but monitor for interactions
What to do: Monitor for any changes
Generally safe with most medications
What to do: Safe concurrent use
Available forms
Wild Yam Root Extract (Standardized Diosgenin): Traditional women's use, Digestive comfort, Good safety profile, Natural source
Food sources
Wild yam root (dried)
Natural diosgenin content · 50
Wild yam tea
Moderate compound extraction · 45
Standardized extracts
Concentrated diosgenin · 55
Not found in common foods
Specific herb preparation required · N/A
Too little
- Not applicable (herbal supplement, not essential nutrient):
- General symptoms addressed by wild yam:
- Digestive cramping and discomfort
- Menstrual cramping and PMS symptoms
- General digestive upset and spasms
- Women's comfort and wellness needs
- Inflammatory discomfort
Too much
- Very safe with minimal side effects:
- Mild digestive upset with high doses
- Rare nausea or stomach discomfort
- Generally well tolerated
- No significant toxicity reported
Who benefits most
digestive-cramping-discomfort
Traditional antispasmodic support for digestive cramping and discomfort
425-850mg daily
menstrual-cramping-pms
Traditional menstrual comfort and PMS symptom relief
425-850mg daily
women-traditional-wellness
Traditional women's health support and overall wellness
425mg daily
perimenopause-comfort
Traditional support for menopausal transition comfort
425-850mg daily
anti-inflammatory-support
Natural anti-inflammatory support for general wellness
425mg dailyWhere to buy it
Look for Wild Yam at 425-850mg per serving. The form that matters here is Wild Yam Root Extract (Standardized Diosgenin).
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How it works
- Diosgenin provides traditional women's health support (though not hormone conversion)
- Natural antispasmodic compounds may help relax smooth muscle tissue
- Saponins and other compounds may provide anti-inflammatory effects
- Traditional use suggests support for digestive comfort and cramping relief
- May provide mild support for overall women's wellness and comfort
- Contains various phytochemicals that support general health and vitality
Key findings
what the evidence supports- Extensive traditional use for women's health and digestive comfort
- Limited clinical research on human hormonal effects
- Diosgenin does not convert to progesterone in the human body
- Generally safe with good tolerability profile
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Wild Yam?
Documented effects: Traditional women's hormonal support; Digestive and antispasmodic support; Menstrual comfort and PMS relief; Anti-inflammatory support. Traditionally used for women's hormonal balance and comfort
How much Wild Yam should you take per day?
The common daily range is 425-850mg. By goal — digestive support: 425-850mg daily; menstrual comfort: 425-850mg daily; traditional wellness: 425mg daily; anti inflammatory: 425mg daily.
When is the best time to take Wild Yam?
With meals. First effects are typically reported within 2-8 weeks for digestive and antispasmodic benefits.
What are the side effects of Wild Yam?
At excessive doses: Very safe with minimal side effects:, Mild digestive upset with high doses, Rare nausea or stomach discomfort, Generally well tolerated, No significant toxicity reported. Safety rating at normal doses is 8 out of 10.
What should you not take with Wild Yam?
Separate it from Unrealistic Hormone Expectations by two to four hours. Does not provide direct hormone replacement effects
Does Wild Yam interact with medications?
Documented interactions with diabetes-medications, hormone-medications, no-major-interactions. Discuss these with a pharmacist before combining.
How do you know if you need Wild Yam?
The marker is Blood glucose if diabetic, general wellness markers, optimal range Stable blood sugar, improved comfort symptoms. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by wild yam:, Digestive cramping and discomfort, Menstrual cramping and PMS symptoms.