Clostridium butyricum

Beneficial spore-forming probiotic bacteria that produces butyric acid, supports gut health, immune function, and may help with inflammatory bowel conditions

Scientific nameClostridium butyricum FormulaSpore-forming bacterial culture Molecular weightN/A - Living spore-forming organism g/mol CASN/A - Probiotic strain

85 absorption score

9 safety / 10

40 USD per month

6 documented interactions

Check it against something

No documented links

Clostridium butyricum with:

70 out of 100

No known interaction No documented interaction. Standard timing for each applies.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Enhanced butyric acid production for colon health

Produces butyric acid, essential fuel for colon cells and gut barrier function

Ferments fiber into butyrate, supporting colonocyte metabolism Evidence A-grade 2-6 weeks of consistent supplementation

Improved inflammatory bowel condition support

May help reduce inflammation in IBD, IBS, and other inflammatory conditions

Produces anti-inflammatory compounds and modulates immune response Evidence B-grade 4-12 weeks of regular use

Strengthened gut barrier function

Enhances intestinal barrier integrity and reduces intestinal permeability

Butyrate strengthens tight junctions and supports epithelial cells Evidence A-grade 3-8 weeks of consistent use

Enhanced immune system regulation

Modulates immune response and reduces excessive inflammation

Produces regulatory compounds affecting T-cell and cytokine activity Evidence B-grade 4-8 weeks of regular supplementation

Improved antibiotic-associated diarrhea prevention

May help prevent diarrhea during antibiotic treatment

Maintains gut microbiome balance and competes with pathogens Evidence B-grade 1-3 weeks during antibiotic treatment

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Probiotics for Autoimmune Disease Support Gut health & immune modulation 10-100 billion CFU daily B 60% Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 90% Magnesium Citrate Balanced absorption & digestive support 300-600 mg A 35% Chloride Electrolyte & digestive support 2300mg A 95% Bone Broth Collagen Gut healing & collagen support 20-40g powder B 85% Psyllium Husk Digestive health & cholesterol support 5-15g A 95%

Every pair we checked

12 combinations scored by the engine

Clostridium butyricum + Caffeine No documented interaction either way No known interaction 70

Clostridium butyricum + Creatine Monohydrate No documented interaction either way No known interaction 70

Clostridium butyricum + Vitamin D3 No documented interaction either way No known interaction 70

Clostridium butyricum + Calcium Carbonate No documented interaction either way No known interaction 70

Clostridium butyricum + Whey Protein No documented interaction either way No known interaction 70

Clostridium butyricum + Lactase No documented interaction either way No known interaction 70

Clostridium butyricum + Bovine Collagen No documented interaction either way No known interaction 70

Clostridium butyricum + DHA No documented interaction either way No known interaction 70

Clostridium butyricum + Turmeric No documented interaction either way No known interaction 70

Clostridium butyricum + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70

Clostridium butyricum + Magnesium Oxide No documented interaction either way No known interaction 70

Clostridium butyricum + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula Synergistic anti-inflammatory effects for gut health Works better together 78

Dosage

With meals and fiber

Daily1-3 billion CFU

Inflammatory conditions1-3 billion CFU daily with meals

Gut barrier support1-3 billion CFU daily

Colon health1-3 billion CFU daily with fiber

Antibiotic recovery2-4 billion CFU daily during treatment

When to expect it

First Effects1-2 weeks for initial gut barrier improvements

Peak Benefits4-12 weeks for maximum gut health and inflammatory benefits

Deficiency DevelopmentBeneficial bacteria depleted by antibiotics, low-fiber diet, stress

Toxicity OnsetNo known toxicity - safe probiotic

How to measure it

$300-500

MarkerButyrate levels, inflammatory markers, gut barrier function markers

OptimalAdequate butyrate production, reduced inflammatory markers

Deficient belowLow butyrate levels, elevated inflammatory markers

FrequencyMonitor for inflammatory bowel conditions and gut health optimization

Works better with

3 documented

Dietary Fiber

Enhanced butyrate production and probiotic effectiveness

Fiber provides substrate for butyrate fermentation · level A

Omega 3 Fatty Acids

Synergistic anti-inflammatory effects for gut health

Both reduce inflammation through different pathways · level B

Prebiotic Resistant Starch

Improved butyrate production and colon health

Resistant starch is preferentially fermented to butyrate · level A

What not to take with Clostridium butyricum

3 documented

Broad Spectrum Antibiotics

Antibiotics may eliminate C. butyricum and disrupt gut microbiome

Antimicrobial action kills beneficial bacteria · high significance

Low Fiber Diet

Insufficient fiber reduces butyrate production effectiveness

Lack of fermentation substrate limits butyrate synthesis · high significance

Artificial Sweeteners

Some artificial sweeteners may negatively impact gut bacteria

Alters gut microbiome composition and diversity · moderate significance

Medication interactions

Discuss these with a pharmacist before combining

antibiotics Moderate

Antibiotics may reduce C. butyricum viability

What to do: Take probiotics 2-3 hours after antibiotic doses

immunosuppressive-medications Minor

Theoretical infection risk in severely immunosuppressed patients

What to do: Use caution in severe immunosuppression

Available forms

bioavailability compared

Clostridium butyricum Miyairi 588 (Clinical strain) 85

Clostridium butyricum Miyairi 588 (Clinical strain): Butyrate production, Gut barrier support, Anti-inflammatory, Clinical research

Food sources

before you supplement

Fermented foods (limited natural sources) Variable, typically low levels · 60

Soil-based organisms (environmental) Natural environmental presence · 50

High-fiber fermented foods 10^4-10^6 CFU per serving · 70

C. butyricum probiotic supplements 1-10 billion CFU per serving · 85

Too little

deficiency signs

Butyrate deficiency and gut microbiome imbalance symptoms:
Inflammatory bowel conditions and chronic gut inflammation
Compromised gut barrier function and leaky gut syndrome
Poor colon health and increased colorectal disease risk
Dysregulated immune response and excessive inflammation
Antibiotic-associated diarrhea and digestive disruption
Reduced short-chain fatty acid production

Too much

toxicity signs

Generally safe with minimal adverse effects:
Temporary digestive adjustment during initial supplementation
Very rare bacterial overgrowth in severely immunocompromised
No documented serious adverse effects in healthy individuals
Safe for daily long-term use

Who benefits most

inflammatory-bowel-conditions

May help reduce inflammation in IBD, IBS, and related conditions

1-3 billion CFU daily with meals

gut-barrier-dysfunction

Strengthens intestinal barrier and reduces leaky gut syndrome

1-3 billion CFU daily

colon-health-optimization

Produces butyrate essential for colon cell health and function

1-3 billion CFU daily with fiber

immune-system-regulation

Modulates immune response and reduces excessive inflammation

1-3 billion CFU daily

antibiotic-recovery

May help prevent antibiotic-associated diarrhea

2-4 billion CFU daily during treatment

Where to buy it

compare forms first

Look for Clostridium butyricum at 1-3 billion CFU per serving. The form that matters here is Clostridium butyricum Miyairi 588 (Clinical strain).

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What else affects it

Beyond other supplements

Dietary fiber

Enhanced butyrate production and probiotic effectiveness

Fiber provides substrate for butyrate fermentation

Low fiber diet

Insufficient fiber reduces butyrate production effectiveness

Lack of fermentation substrate limits butyrate synthesis

Artificial sweeteners

Some artificial sweeteners may negatively impact gut bacteria

Alters gut microbiome composition and diversity

How it works

Ferments dietary fiber into butyric acid in the colon
Butyrate serves as primary fuel for colonocytes and gut barrier cells
Produces anti-inflammatory compounds reducing intestinal inflammation
Strengthens tight junctions improving gut barrier function
Modulates immune cell activity and cytokine production
Competes with pathogenic bacteria for nutrients and colonization sites

Key findings

what the evidence supports

Proven butyrate production capabilities essential for colon health
Promising evidence for inflammatory bowel condition support
Strong evidence for gut barrier function enhancement
Good safety profile with minimal adverse effects

Sources: NIH Examine.com · data reviewed 2026-08-01

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Clostridium butyricum?

Documented effects: Enhanced butyric acid production for colon health; Improved inflammatory bowel condition support; Strengthened gut barrier function; Enhanced immune system regulation. Produces butyric acid, essential fuel for colon cells and gut barrier function

How much Clostridium butyricum should you take per day?

The common daily range is 1-3 billion CFU. By goal — inflammatory conditions: 1-3 billion CFU daily with meals; gut barrier support: 1-3 billion CFU daily; colon health: 1-3 billion CFU daily with fiber; antibiotic recovery: 2-4 billion CFU daily during treatment.

When is the best time to take Clostridium butyricum?

With meals and fiber. First effects are typically reported within 1-2 weeks for initial gut barrier improvements.

What are the side effects of Clostridium butyricum?

At excessive doses: Generally safe with minimal adverse effects:, Temporary digestive adjustment during initial supplementation, Very rare bacterial overgrowth in severely immunocompromised, No documented serious adverse effects in healthy individuals, Safe for daily long-term use. Safety rating at normal doses is 9 out of 10.

What should you not take with Clostridium butyricum?

Separate it from Broad Spectrum Antibiotics, Low Fiber Diet, Artificial Sweeteners by two to four hours. Antibiotics may eliminate C. butyricum and disrupt gut microbiome

Does Clostridium butyricum interact with medications?

Documented interactions with antibiotics, immunosuppressive-medications. Discuss these with a pharmacist before combining.

How do you know if you need Clostridium butyricum?

The marker is Butyrate levels, inflammatory markers, gut barrier function markers, optimal range Adequate butyrate production, reduced inflammatory markers. Common deficiency signs: Butyrate deficiency and gut microbiome imbalance symptoms:, Inflammatory bowel conditions and chronic gut inflammation, Compromised gut barrier function and leaky gut syndrome, Poor colon health and increased colorectal disease risk.

Taken for

74 Digestion

Lactase · Lactobacillus acidophilus · Protease