Check a pair

Supplements for Sleep & Stress

Sleep & Stress: 29 compounds are used here, 12 of them at evidence level A. The most used is Magnesium Glycinate. Between them there are 148 documented interactions — which is why the order and timing of a stack matters as much as the choice.

0 compounds
0 interactions
0 evidence A

Where the evidence is strongest

Ranked by popularity, with what each one actually does

Magnesium Glycinate

Superior absorption sleep & muscle support

200-600 mg Evening with or without food Evidence A 90% absorbed

Melatonin

Sleep support & circadian rhythm

0.5-3mg 30 60 minutes before bed Evidence A 50% absorbed

Ashwagandha

Stress management & energy

300-600mg With food Evidence A 75% absorbed

L-Theanine

Calm focus & stress relief

100-400mg As needed or with caffeine Evidence B 90% absorbed

Panax Ginseng

Energy enhancement & stress adaptation

200-400mg Morning with meals Evidence A 80% absorbed

What these are, chemically

7 types
Botanicals 16 Amino Acids 5 Minerals 2 Compounds 2 Blends & Formulas 2 Probiotics 1 Vitamins 1

Choosing between forms

Same compound, different absorption
Magnesium Glycinate vs ZMA (Zinc + Magnesium + B6) 90% · 75%

All 29 compounds

dose · evidence · documented interactions
Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 5 Melatonin Sleep support & circadian rhythm 0.5-3mg A 6 Ashwagandha Stress management & energy 300-600mg A 5 L-Theanine Calm focus & stress relief 100-400mg B 5 Panax Ginseng Energy enhancement & stress adaptation 200-400mg A 5 Lemon Balm Stress relief & sleep support 300-1200mg B 5 Schisandra Berry Stress adaptation & performance 500-1500mg A 5 Lactobacillus helveticus Stress reduction & cardiovascular support 1-10 billion CFU A 6 Glycine Sleep quality & collagen support 3-10g A 5 ZMA (Zinc + Magnesium + B6) Sleep & recovery enhancement ZMA formula before bed B 6 L-Tyrosine Stress response & cognitive support 500-2000mg A 5 Valerian Root Sleep support & relaxation 300-900mg B 5 L-Tryptophan Sleep support & mood enhancement 500-2000mg A 5 Schisandra Liver protection & stress adaptation 300-1000mg B 5 Centella Asiatica Cognitive enhancement & anxiety relief 500-2000mg B 5 Eleuthero (Siberian Ginseng) Endurance & stress adaptation 300-800mg B 5 Cortisol Manager Complex Comprehensive stress management Varies by product (2-4 capsules typically) B 5 St. John's Wort Depression & anxiety relief 600-900mg A 5 Kava Kava Anxiety relief & deep relaxation 300-1200mg extract B 5 Vitamin B5 (Pantothenic Acid) Energy metabolism & stress support 100-500 mg A 5 Tart Cherry Extract Natural recovery & sleep support 240-480ml juice or equivalent B 5 Passion Flower Anxiety relief & relaxation 200-400mg B 5 Magnolia Bark Stress relief & cortisol support 200-800mg C 5 Adaptogenic Stress Complex Stress adaptation & resilience Varies by product (2-4 capsules typically) A 5 5-HTP (5-Hydroxytryptophan) Mood support & sleep enhancement 50-300mg B 5 Jujube Sleep support & gentle calming 500-2000mg C 5 Reishi Stress relief & sleep support 500-2000mg B 5 GABA (Gamma-Aminobutyric Acid) Natural relaxation & anxiety relief 250-1000mg C 5 Holy Basil Stress relief & blood sugar support 300-600mg C 5

Common questions

What are the best supplements for sleep & stress?

By usage and evidence: Magnesium Glycinate, Melatonin, Ashwagandha. 12 compounds here carry evidence level A, meaning the effect was studied directly rather than inferred.

How many supplements for sleep & stress can you take at once?

There is no fixed limit, but every added compound multiplies possible interactions. The compounds on this page have 148 documented interactions between them — check a pair before stacking it.

How long until supplements for sleep & stress start working?

Depends on the compound. Each page lists first effects and peak benefit windows separately, because the two differ by weeks for most compounds.