Stress reduction and adaptogenic effects
Helps body adapt to stress and promotes relaxation
Reishi
Adaptogenic mushroom traditionally used for longevity, immune support, stress reduction, and overall wellness enhancement
Scientific nameGanoderma lucidum
FormulaComplex triterpenes and polysaccharides
Molecular weightVariable bioactive compounds g/mol
CASVarious natural compounds
70
absorption score
8
safety / 10
45
USD per month
5
documented interactions
Check it against something
Reishi with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimEnhanced immune system function
Supports and modulates immune response
Improved sleep quality
Promotes deeper, more restful sleep
Liver health and detoxification
Supports liver function and cellular detox
Cardiovascular and cholesterol support
May help maintain healthy cholesterol and heart function
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Probiotics for Autoimmune Disease Support
Gut health & immune modulation
10-100 billion CFU daily
B
60%
Melatonin
Sleep support & circadian rhythm
0.5-3mg
A
50%
Ashwagandha
Stress management & energy
300-600mg
A
75%
Magnesium Glycinate
Superior absorption sleep & muscle support
200-600 mg
A
90%
Vitamin D3
Bone health & immune support
1000-2000 IU
A
85%
L-Theanine
Calm focus & stress relief
100-400mg
B
90%
Every pair we checked
12 combinations scored by the engine
Reishi + Caffeine
May counteract calming and sleep benefits
Needs attention
61
Reishi + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Reishi + Vitamin D3
No documented interaction either way
No known interaction
70
Reishi + Calcium Carbonate
No documented interaction either way
No known interaction
70
Reishi + Whey Protein
No documented interaction either way
No known interaction
70
Reishi + Lactase
No documented interaction either way
No known interaction
70
Reishi + Bovine Collagen
No documented interaction either way
No known interaction
70
Reishi + DHA
No documented interaction either way
No known interaction
70
Reishi + Turmeric
No documented interaction either way
No known interaction
70
Reishi + Melatonin
Enhanced sleep quality and timing
Works better together
75
Reishi + Ashwagandha
Enhanced adaptogenic and stress-reducing benefits
Works better together
78
Reishi + Magnesium Oxide
Enhanced relaxation and sleep benefits
Works better together
78
Dosage
Daily500-2000mg
Stress management500-1500mg daily
Sleep support1000-2000mg before bed
Immune support500-1500mg daily
Liver detox1000-2000mg daily
Before you take it
VeganYes
When to expect it
First Effects1-3 weeks for sleep and stress benefits
Peak Benefits6-12 weeks for sustained immune and health benefits
Deficiency DevelopmentReturn to baseline stress and immune function
Toxicity OnsetRare, mainly with poor quality products
How to measure it
MarkerCortisol levels, immune markers, or liver function tests
OptimalReduced stress markers and improved immune function
Deficient belowNot applicable for supplement
FrequencyMonitor stress and immune markers as needed
What people actually reported to the FDA
CAERS, 10 reports naming it as the suspectMost reported effects
Named as the suspect
10 reports
of 22 that mention it at all
Serious outcome
81%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event6
Hospitalization3
Visited a Health Care Provider3
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
High 70 of 100 · absorbs well relative to other forms
Delivered daily
875 mg
Cost per 100 mg delivered
$0.17 comparative — uses the absorption score, not a measured percentage
Works better with
+
Ashwagandha
Enhanced adaptogenic and stress-reducing benefits
Complementary adaptogens for stress management · level B
+
Magnesium
Enhanced relaxation and sleep benefits
Both support GABA and relaxation pathways · level B
+
Melatonin
Enhanced sleep quality and timing
Complementary sleep-promoting compounds · level CWhat not to take with Reishi
!
Stimulants Caffeine
May counteract calming and sleep benefits
Stimulants oppose relaxation effects · minor significance
!
Alcohol
May increase sedative effects
Both can cause drowsiness · minor significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance blood pressure lowering effects
What to do: Monitor blood pressure
May enhance bleeding risk
What to do: Monitor bleeding parameters
May enhance sedative effects
What to do: Avoid combination or reduce doses
Available forms
Reishi Extract (Standardized): Standardized potency, Higher concentration, Better absorption, Consistent effects
Whole Reishi Powder: Complete spectrum, Natural form, Lower cost, Traditional use
Food sources
Wild reishi mushrooms
Rare and bitter, not typically consumed · 50
Reishi extract supplements
500-2000mg per capsule · 70-75
Reishi powder
Variable concentration · 60
Reishi tea/tinctures
Lower concentration · 55
Too little
- Not essential - but symptoms addressed by reishi:
- Chronic stress and poor stress adaptation
- Sleep problems and insomnia
- Frequent infections and immune dysfunction
- Liver dysfunction and poor detoxification
- Anxiety and nervous tension
- Premature aging and low vitality
Too much
- Generally safe but potential concerns:
- Liver toxicity with poor quality products
- Dizziness and fatigue in sensitive individuals
- Low blood pressure with medications
- Skin rashes in rare allergic reactions
Who benefits most
stress-anxiety-management
Excellent adaptogen for stress reduction and calm energy
500-1500mg daily
sleep-quality-insomnia
Promotes deeper, more restful sleep naturally
1000-2000mg before bed
immune-system-support
Powerful immune modulator and enhancer
500-1500mg daily
liver-health-detox
Supports liver function and detoxification
1000-2000mg daily
aging-longevity-wellness
Traditional longevity and anti-aging mushroom
500-1000mg dailyWhere to buy it
Look for Reishi at 500-2000mg per serving. The form that matters here is Reishi Extract (Standardized).
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What else affects it
Beyond other supplements
!
Alcohol
May increase sedative effects
Both can cause drowsinessHow it works
- Triterpenes provide adaptogenic stress-reducing effects
- Beta-glucans and polysaccharides enhance immune function
- Ganoderic acids support liver health and detoxification
- Compounds may modulate neurotransmitters for sleep and calm
- Antioxidants protect cells from oxidative stress
- May influence HPA axis for stress adaptation
Key findings
what the evidence supports- Good evidence for stress reduction and adaptogenic effects
- Moderate evidence for immune support and sleep quality
- Generally safe but quality sourcing important
- Promising for liver health and longevity benefits
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Reishi?
Documented effects: Stress reduction and adaptogenic effects; Enhanced immune system function; Improved sleep quality; Liver health and detoxification. Helps body adapt to stress and promotes relaxation
How much Reishi should you take per day?
The common daily range is 500-2000mg. By goal — stress management: 500-1500mg daily; sleep support: 1000-2000mg before bed; immune support: 500-1500mg daily; liver detox: 1000-2000mg daily.
When is the best time to take Reishi?
Evening or with meals. First effects are typically reported within 1-3 weeks for sleep and stress benefits.
What are the side effects of Reishi?
At excessive doses: Generally safe but potential concerns:, Liver toxicity with poor quality products, Dizziness and fatigue in sensitive individuals, Low blood pressure with medications, Skin rashes in rare allergic reactions. Safety rating at normal doses is 8 out of 10.
What should you not take with Reishi?
Separate it from Stimulants Caffeine, Alcohol by two to four hours. May counteract calming and sleep benefits
Does Reishi interact with medications?
Documented interactions with blood-pressure-medications, anticoagulants, sedatives-sleep-medications. Discuss these with a pharmacist before combining.
How do you know if you need Reishi?
The marker is Cortisol levels, immune markers, or liver function tests, optimal range Reduced stress markers and improved immune function. Common deficiency signs: Not essential - but symptoms addressed by reishi:, Chronic stress and poor stress adaptation, Sleep problems and insomnia, Frequent infections and immune dysfunction.