Cognitive enhancement and mental clarity
Improves cognitive function, mental clarity, and brain performance
Centella Asiatica
Traditional brain tonic and nerve regeneration herb supporting cognitive function, anxiety reduction, and neural health
Scientific nameCentella asiatica
FormulaC30H48O6 (asiaticoside)
Molecular weight520.7 g/mol
CAS16830-15-2
70
absorption score
8
safety / 10
30
USD per month
5
documented interactions
Check it against something
Centella Asiatica with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Ginkgo Biloba
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
75
out of 100
Works better together
Take together — same timing window amplifies the synergy.
What it does
mechanism and evidence for each claimAnxiety and stress reduction
Reduces anxiety, stress, and promotes mental calmness
Nerve regeneration and neuroprotection
Supports nerve growth and protects against neurodegeneration
Memory and learning enhancement
Improves memory formation and learning capacity
Circulation and brain blood flow
Improves circulation and blood flow to the brain
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Melatonin
Sleep support & circadian rhythm
0.5-3mg
A
50%
Ashwagandha
Stress management & energy
300-600mg
A
75%
Magnesium Glycinate
Superior absorption sleep & muscle support
200-600 mg
A
90%
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
L-Theanine
Calm focus & stress relief
100-400mg
B
90%
Every pair we checked
12 combinations scored by the engine
Centella Asiatica + Caffeine
No documented interaction either way
No known interaction
70
Centella Asiatica + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Centella Asiatica + Calcium Carbonate
No documented interaction either way
No known interaction
70
Centella Asiatica + Whey Protein
No documented interaction either way
No known interaction
70
Centella Asiatica + Lactase
No documented interaction either way
No known interaction
70
Centella Asiatica + Bovine Collagen
No documented interaction either way
No known interaction
70
Centella Asiatica + DHA
No documented interaction either way
No known interaction
70
Centella Asiatica + Turmeric
No documented interaction either way
No known interaction
70
Centella Asiatica + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Centella Asiatica + Bacopa Monnieri
Enhanced cognitive function and memory support
Works better together
75
Centella Asiatica + Ginkgo Biloba
Improved brain circulation and cognitive performance
Works better together
75
Centella Asiatica + Vitamin D3
Comprehensive nervous system support
Works better together
75
Dosage
Daily500-2000mg
Anxiety relief500-1000mg daily
Cognitive enhancement750-1500mg daily
Nerve regeneration1000-2000mg daily
Memory support750-1500mg daily
Before you take it
VeganYes
When to expect it
First Effects2-6 weeks for anxiety reduction and mental clarity
Peak Benefits8-16 weeks for sustained cognitive enhancement and neuroprotection
Deficiency DevelopmentNot applicable - herbal supplement
Toxicity OnsetRare, mainly with very high doses
How to measure it
MarkerLiver enzymes if using high doses long-term
OptimalNormal liver function, reduced anxiety markers
Deficient belowNot applicable for herbal supplement
FrequencyEvery 6-12 months if using high doses (>1500mg daily)
What actually reaches you
The label counts the carrier, your body does not
Absorption
High 70 of 100 · absorbs well relative to other forms
Delivered daily
875 mg
Cost per 100 mg delivered
$0.11 comparative — uses the absorption score, not a measured percentage
Works better with
+
Brahmi Bacopa
Enhanced cognitive function and memory support
Both support brain function through complementary pathways · level C
+
Ginkgo Biloba
Improved brain circulation and cognitive performance
Synergistic effects on cerebral circulation and neural function · level C
+
B Complex Vitamins
Comprehensive nervous system support
B vitamins support nerve function that centella helps regenerate · level CWhat not to take with Centella Asiatica
!
Sedative Medications
May enhance sedative effects
Additive calming and sedating effects · moderate significance
!
Hepatotoxic Substances
May increase liver stress with very high doses
Additive liver burden · mild significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance sedative effects
What to do: Monitor for increased sedation, adjust doses
May affect blood sugar levels
What to do: Monitor blood glucose levels
Theoretical interaction with high doses
What to do: Monitor liver function with high doses
Available forms
Centella Asiatica Extract (Standardized Asiaticoside): Anxiety relief, Cognitive enhancement, Nerve regeneration, Traditional use
Food sources
Fresh centella leaves
Natural triterpenoid content · 65
Centella juice
Liquid extract form · 70
Dried centella powder
Concentrated compounds · 60
Standardized extracts
Concentrated asiaticoside · 70
Too little
- Not applicable (herbal supplement, not essential nutrient):
- General symptoms addressed by centella asiatica:
- High anxiety and stress levels
- Poor cognitive function and mental fog
- Nerve damage and poor neural regeneration
- Memory problems and learning difficulties
- Poor brain circulation and mental fatigue
Too much
- Generally safe with some considerations:
- Drowsiness and sedation with high doses
- Rare liver enzyme elevation with very high doses
- Skin sensitivity or photosensitivity
- Headaches (rare)
Who benefits most
anxiety-stress-mental-calm
Excellent natural anxiety relief and stress reduction without sedation
500-1000mg daily
cognitive-enhancement-focus
Traditional cognitive enhancement and mental clarity support
750-1500mg daily
nerve-health-regeneration
Nerve regeneration and neuroprotection support for neural health
1000-2000mg daily
memory-learning-students
Memory and learning enhancement for students and knowledge workers
750-1500mg daily
circulation-brain-health
Brain circulation and overall brain health maintenance
500-1000mg dailyWhere to buy it
Look for Centella Asiatica at 500-2000mg per serving. The form that matters here is Centella Asiatica Extract (Standardized Asiaticoside).
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How it works
- Triterpenoids (asiaticoside, madecassoside) enhance neural communication and brain function
- Modulates GABA neurotransmission promoting relaxation and anxiety reduction
- Stimulates nerve growth factor (NGF) promoting neuroplasticity and regeneration
- Enhances cholinergic function supporting memory and learning processes
- Vasodilatory effects improve cerebral circulation and oxygen delivery
- Antioxidant properties protect brain tissue from oxidative damage
Key findings
what the evidence supports- Good evidence for anxiety reduction and stress relief
- Promising research on cognitive enhancement and nerve regeneration
- Strong traditional use validation for brain and nerve health
- Generally safe but caution with high doses and liver function
Sources: NIH Examine.com · data reviewed 2026-08-01
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Centella Asiatica?
Documented effects: Cognitive enhancement and mental clarity; Anxiety and stress reduction; Nerve regeneration and neuroprotection; Memory and learning enhancement. Improves cognitive function, mental clarity, and brain performance
How much Centella Asiatica should you take per day?
The common daily range is 500-2000mg. By goal — anxiety relief: 500-1000mg daily; cognitive enhancement: 750-1500mg daily; nerve regeneration: 1000-2000mg daily; memory support: 750-1500mg daily.
When is the best time to take Centella Asiatica?
With meals. First effects are typically reported within 2-6 weeks for anxiety reduction and mental clarity.
What are the side effects of Centella Asiatica?
At excessive doses: Generally safe with some considerations:, Drowsiness and sedation with high doses, Rare liver enzyme elevation with very high doses, Skin sensitivity or photosensitivity, Headaches (rare). Safety rating at normal doses is 8 out of 10.
What should you not take with Centella Asiatica?
Separate it from Sedative Medications, Hepatotoxic Substances by two to four hours. May enhance sedative effects
Does Centella Asiatica interact with medications?
Documented interactions with sedative-medications, diabetes-medications, liver-metabolized-medications. Discuss these with a pharmacist before combining.
How do you know if you need Centella Asiatica?
The marker is Liver enzymes if using high doses long-term, optimal range Normal liver function, reduced anxiety markers. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by centella asiatica:, High anxiety and stress levels, Poor cognitive function and mental fog.