Anti-aging and longevity support
Helps maintain youthful hormone levels and cellular function
DHEA (Dehydroepiandrosterone)
Steroid hormone precursor produced by adrenal glands, often called the 'youth hormone' for its anti-aging and vitality benefits
Scientific nameDehydroepiandrosterone
FormulaC19H28O2
Molecular weight288.42 g/mol
CAS53-43-0
80
absorption score
6
safety / 10
25
USD per month
5
documented interactions
Check it against something
DHEA (Dehydroepiandrosterone) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimEnhanced energy and vitality
Boosts energy levels, motivation, and overall sense of well-being
Improved mood and cognitive function
Supports positive mood, mental clarity, and stress resilience
Enhanced immune system function
Supports healthy immune response and resistance to illness
Bone density and muscle mass support
Helps maintain bone density and lean muscle mass with aging
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Melatonin
Sleep support & circadian rhythm
0.5-3mg
A
50%
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Bone Broth Collagen
Gut healing & collagen support
20-40g powder
B
85%
Vitamin B7 (Biotin)
Hair, skin & nail health
300-5000 mcg
A
80%
Vitamin B3 (Niacinamide)
Energy & skin health (no flush)
100-1000 mg
A
88%
Marine Collagen
Anti-aging & skin health
5-15g
A
95%
Every pair we checked
12 combinations scored by the engine
DHEA (Dehydroepiandrosterone) + Caffeine
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Calcium Carbonate
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Whey Protein
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Lactase
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Bovine Collagen
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + DHA
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Turmeric
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
DHEA (Dehydroepiandrosterone) + Magnesium Oxide
Enhanced DHEA utilization and stress response
Works better together
75
DHEA (Dehydroepiandrosterone) + Vitamin D3
Enhanced hormone production and bone health
Works better together
78
DHEA (Dehydroepiandrosterone) + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced hormone production and bone health
Works better together
83
Dosage
Daily10-25mg daily
Anti aging maintenance10-25mg daily
Energy mood support15-25mg daily
Therapeutic higher dose25-50mg daily under supervision
MaximumGenerally not more than 50mg daily without medical oversight
When to expect it
First Effects2-4 weeks for initial energy and mood improvements
Peak Benefits8-16 weeks for optimal hormonal and anti-aging benefits
Deficiency DevelopmentNatural decline begins around age 25-30
Toxicity OnsetSide effects may occur with doses above 50mg daily
How to measure it
MarkerDHEA-S (sulfate), testosterone, estradiol, cortisol, liver enzymes
OptimalDHEA-S: 250-400 μg/dL (varies by age and gender)
Deficient belowDHEA-S: <100 μg/dL
FrequencyBaseline, then 8-12 weeks after starting, then every 6 months
What people actually reported to the FDA
CAERS, 100 reports naming it as the suspectMost reported effects
Named as the suspect
100 reports
of 140 that mention it at all
Serious outcome
73%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event48
Hospitalization23
Visited a Health Care Provider22
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 80 of 100 · best absorbed form of this compound
Delivered daily
14 mg
Cost per 100 mg delivered
$5.95 comparative — uses the absorption score, not a measured percentage
Works better with
+
Vitamin D3
Enhanced hormone production and bone health
Both support steroid hormone pathways · level B
+
Omega 3 Fatty Acids
Improved hormone synthesis and anti-inflammatory effects
Provide building blocks for hormone production · level C
+
Magnesium
Enhanced DHEA utilization and stress response
Cofactor for steroidogenic enzymes · level CWhat not to take with DHEA (Dehydroepiandrosterone)
!
Excessive Cortisol
Competes with DHEA production
Both derived from pregnenolone precursor · high significance
!
Alcohol Excess
Impairs DHEA synthesis and metabolism
Disrupts steroidogenic enzyme function · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay have additive hormonal effects
What to do: Requires medical supervision and monitoring
May improve insulin sensitivity
What to do: Monitor blood glucose levels
May enhance sedative effects
What to do: Monitor for increased drowsiness
Available forms
Micronized DHEA: Well-researched, Anti-aging benefits, Energy support, Mood enhancement
Food sources
Natural endogenous production only
Cannot be obtained from food sources · N/A
Wild yam (precursor compounds)
Contains diosgenin, not bioactive DHEA · 5
DHEA supplements
Synthetic DHEA identical to endogenous hormone · 80
Too little
- Low DHEA symptoms (common with aging):
- Decreased energy and fatigue
- Reduced muscle mass and strength
- Mood changes and depression
- Decreased libido and sexual function
- Poor stress tolerance
- Weakened immune function
Too much
- DHEA excess or sensitivity symptoms:
- Acne and oily skin
- Hair loss or unwanted hair growth
- Mood swings and irritability
- Sleep disturbances
- Voice changes (in women)
- Liver enzyme elevation (rare)
Who benefits most
adults-over-40-aging
Natural DHEA decline with aging
10-25mg daily, preferably morning
low-energy-fatigue
Support for energy and vitality
10-25mg daily with monitoring
mood-depression-support
Hormonal support for mood and well-being
15-25mg daily under supervision
immune-system-support
Age-related immune system decline
10-25mg daily
bone-muscle-health
Support for aging-related tissue changes
15-25mg daily with resistance exerciseWhere to buy it
Look for DHEA (Dehydroepiandrosterone) at 10-25mg daily per serving. The form that matters here is Micronized DHEA.
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What else affects it
Beyond other supplements
!
Excessive cortisol
Competes with DHEA production
Both derived from pregnenolone precursor
!
Alcohol excess
Impairs DHEA synthesis and metabolism
Disrupts steroidogenic enzyme functionHow it works
- Serves as precursor to testosterone, estrogen, and other steroid hormones
- Supports hypothalamic-pituitary-adrenal (HPA) axis function
- Modulates immune system activity and inflammatory responses
- Enhances mitochondrial function and cellular energy production
- Influences neurotransmitter production and brain function
- Supports protein synthesis and tissue maintenance
Key findings
what the evidence supports- DHEA supplementation can restore youthful hormone levels in deficient adults
- Most effective in people over 40 with documented low DHEA levels
- Benefits include improved energy, mood, and immune function
- Requires monitoring due to potential hormonal side effects
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of DHEA (Dehydroepiandrosterone)?
Documented effects: Anti-aging and longevity support; Enhanced energy and vitality; Improved mood and cognitive function; Enhanced immune system function. Helps maintain youthful hormone levels and cellular function
How much DHEA (Dehydroepiandrosterone) should you take per day?
The common daily range is 10-25mg daily. By goal — anti aging maintenance: 10-25mg daily; energy mood support: 15-25mg daily; therapeutic higher dose: 25-50mg daily under supervision; maximum: Generally not more than 50mg daily without medical oversight.
When is the best time to take DHEA (Dehydroepiandrosterone)?
Morning. First effects are typically reported within 2-4 weeks for initial energy and mood improvements.
What are the side effects of DHEA (Dehydroepiandrosterone)?
At excessive doses: DHEA excess or sensitivity symptoms:, Acne and oily skin, Hair loss or unwanted hair growth, Mood swings and irritability, Sleep disturbances. Safety rating at normal doses is 6 out of 10.
What should you not take with DHEA (Dehydroepiandrosterone)?
Separate it from Excessive Cortisol, Alcohol Excess by two to four hours. Competes with DHEA production
Does DHEA (Dehydroepiandrosterone) interact with medications?
Documented interactions with hormone-replacement-therapy, insulin, triazolam. Discuss these with a pharmacist before combining.
How do you know if you need DHEA (Dehydroepiandrosterone)?
The marker is DHEA-S (sulfate), testosterone, estradiol, cortisol, liver enzymes, optimal range DHEA-S: 250-400 μg/dL (varies by age and gender). Common deficiency signs: Low DHEA symptoms (common with aging):, Decreased energy and fatigue, Reduced muscle mass and strength, Mood changes and depression.