Energy metabolism support
Essential component of NAD+ and NADP+ coenzymes
Vitamin B3 (Niacinamide)
Non-flushing form of vitamin B3 essential for energy metabolism, skin health, and cellular repair
Scientific nameNicotinamide
FormulaC6H6N2O
Molecular weight122.12 g/mol
CAS98-92-0
88
absorption score
8
safety / 10
12
USD per month
5
documented interactions
Check it against something
Vitamin B3 (Niacinamide) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
- Zinc Picolinate
Nothing found
99
out of 100
Works better together
Take together — same timing window amplifies the synergy.
What it does
mechanism and evidence for each claimSkin health improvement
Reduces acne, improves skin texture and barrier function
DNA repair and longevity
Supports cellular repair and anti-aging pathways
Mental health support
May help with anxiety, depression, and mood disorders
Joint health support
May improve arthritis symptoms and joint mobility
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Ashwagandha
Stress management & energy
300-600mg
A
75%
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Bone Broth Collagen
Gut healing & collagen support
20-40g powder
B
85%
Every pair we checked
12 combinations scored by the engine
Vitamin B3 (Niacinamide) + L-Tryptophan
Reduces body's ability to make niacinamide from tryptophan
Needs attention
70
Vitamin B3 (Niacinamide) + Caffeine
No documented interaction either way
No known interaction
70
Vitamin B3 (Niacinamide) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Vitamin B3 (Niacinamide) + Whey Protein
No documented interaction either way
No known interaction
70
Vitamin B3 (Niacinamide) + Turmeric
No documented interaction either way
No known interaction
70
Vitamin B3 (Niacinamide) + Lactase
Improved calcium absorption when consuming dairy
Works better together
82
Vitamin B3 (Niacinamide) + Bovine Collagen
Essential for collagen synthesis and cross-linking
Works better together
82
Vitamin B3 (Niacinamide) + DHA
Prevents oxidation of DHA and enhances stability
Works better together
82
Vitamin B3 (Niacinamide) + Vitamin D3
Both support collagen synthesis and skin health
Works better together
86
Vitamin B3 (Niacinamide) + Fish Oil (EPA/DHA)
Protects fish oil from oxidation
Works better together
90
Vitamin B3 (Niacinamide) + Calcium Carbonate
Essential for calcium absorption and utilization
Works better together
94
Vitamin B3 (Niacinamide) + Zinc Gluconate
Both important for skin health and wound healing
Works better together
99
Dosage
Daily100-1000 mg
Maintenance100-500 mg
Therapeutic500-2000 mg
High dose protocols2000-4000 mg (medical supervision)
Topical equivalent2-5% creams for skin application
Upper limit
35 mg NIH ODS
Before you take it
VeganYes
When to expect it
First Effects1-2 weeks for energy and mood improvements
Peak Benefits8-12 weeks for skin and joint benefits
Deficiency Development6-8 weeks with inadequate B3 intake
Toxicity OnsetMonths at very high doses
How to measure it
MarkerNAD+/NADH ratio or urinary N-methylnicotinamide
OptimalVariable depending on test method
Deficient belowLow NAD+ levels or reduced excretion
FrequencyOnly if using high doses or monitoring deficiency
What people actually reported to the FDA
CAERS, 35 reports naming it as the suspectMost reported effects
Named as the suspect
35 reports
of 52 that mention it at all
Serious outcome
82%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event26
Visited Emergency Room15
Life Threatening8
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 88 of 100 · best absorbed form of this compound
Delivered daily
484 mg
Cost per 100 mg delivered
$0.08 comparative — uses the absorption score, not a measured percentage
Works better with
+
Zinc
Both important for skin health and wound healing
Complementary anti-inflammatory and healing effects · level B
+
Vitamin C
Both support collagen synthesis and skin health
Complementary roles in skin structure and repair · level B
+
Other B Vitamins
Work together in energy metabolism
Complementary roles in metabolic pathways · level AWhat not to take with Vitamin B3 (Niacinamide)
!
Alcohol
Increases niacinamide requirements
Competes for NAD+ and increases metabolism · moderate significance
!
Tryptophan Deficiency
Reduces body's ability to make niacinamide from tryptophan
Tryptophan is precursor to niacinamide synthesis · mild significanceMedication interactions
Discuss these with a pharmacist before combiningSome may increase niacinamide requirements
What to do: Monitor for B3 deficiency signs
High doses may affect blood glucose
What to do: Monitor blood glucose if using high doses
Available forms
Niacinamide: No flushing, Better tolerance, Skin benefits, Mental health support
Food sources
Tuna
18.8 mg/100g (as niacin equivalents) · 85
Chicken breast
14.8 mg/100g · 80
Peanuts
12.0 mg/100g · 70
Mushrooms
3.6 mg/100g · 75
Note: Most food B3 is in niacin form, not niacinamide
Body can convert some niacin to niacinamide · 70
Too little
- Same as niacin deficiency:
- Fatigue and weakness
- Depression and irritability
- Poor memory and confusion
- Digestive problems
- Skin lesions (pellagra)
- Rough, darkened skin
Too much
- No flushing reaction (unlike niacin)
- Liver toxicity at very high doses (rare)
- Nausea and digestive upset
- Headache at high doses
- Generally much safer than niacin
- Lower risk profile overall
Who benefits most
acne-sufferers
Niacinamide effectively reduces acne inflammation
500-1000 mg daily
sensitive-to-niacin-flush
Provides B3 benefits without uncomfortable flushing
100-500 mg daily
mental-health-support
May help with anxiety, depression, and schizophrenia
500-3000 mg daily (with supervision)
anti-aging-focused
NAD+ precursor supports cellular repair and longevity
250-1000 mg daily
arthritis-sufferers
May reduce joint inflammation and improve mobility
1000-3000 mg dailyWhere to buy it
Look for Vitamin B3 (Niacinamide) at 100-1000 mg per serving. The form that matters here is Niacinamide.
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What else affects it
Beyond other supplements
!
Alcohol
Increases niacinamide requirements
Competes for NAD+ and increases metabolismHow it works
- Precursor to NAD+ and NADP+ coenzymes
- Essential for glycolysis and Krebs cycle
- Substrate for poly(ADP-ribose) polymerase (DNA repair)
- Anti-inflammatory effects via multiple pathways
- Enhances skin barrier function and ceramide synthesis
- Modulates sebaceous gland activity
Key findings
what the evidence supports- Reduces acne lesions by 60% in clinical trials (Cutis 1995)
- No flushing reaction unlike niacin (established)
- May help with schizophrenia symptoms (orthomolecular research)
- Improves skin barrier function and reduces inflammation (dermatology studies)
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Vitamin B3 (Niacinamide)?
Documented effects: Energy metabolism support; Skin health improvement; DNA repair and longevity; Mental health support. Essential component of NAD+ and NADP+ coenzymes
How much Vitamin B3 (Niacinamide) should you take per day?
The common daily range is 100-1000 mg. By goal — maintenance: 100-500 mg; therapeutic: 500-2000 mg; high dose protocols: 2000-4000 mg (medical supervision); topical equivalent: 2-5% creams for skin application.
When is the best time to take Vitamin B3 (Niacinamide)?
With food. First effects are typically reported within 1-2 weeks for energy and mood improvements.
What are the side effects of Vitamin B3 (Niacinamide)?
At excessive doses: No flushing reaction (unlike niacin), Liver toxicity at very high doses (rare), Nausea and digestive upset, Headache at high doses, Generally much safer than niacin. Safety rating at normal doses is 8 out of 10.
What should you not take with Vitamin B3 (Niacinamide)?
Separate it from Alcohol, Tryptophan Deficiency by two to four hours. Increases niacinamide requirements
Does Vitamin B3 (Niacinamide) interact with medications?
Documented interactions with anticonvulsants, diabetes-medications. Discuss these with a pharmacist before combining.
How much Vitamin B3 (Niacinamide) is too much?
The tolerable upper intake level is 35 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: No flushing reaction (unlike niacin), Liver toxicity at very high doses (rare), Nausea and digestive upset.
How do you know if you need Vitamin B3 (Niacinamide)?
The marker is NAD+/NADH ratio or urinary N-methylnicotinamide, optimal range Variable depending on test method. Common deficiency signs: Same as niacin deficiency:, Fatigue and weakness, Depression and irritability, Poor memory and confusion.