Comprehensive antioxidant protection
All four tocopherols provide broader antioxidant coverage
Vitamin E (Mixed Tocopherols)
Complete vitamin E complex containing all four tocopherol forms for comprehensive antioxidant protection
Scientific nameMixed Tocopherols
FormulaVariable (α, β, γ, δ-tocopherols)
Molecular weightVariable (430-416) g/mol
CASMultiple CAS numbers
70
absorption score
8
safety / 10
18
USD per month
5
documented interactions
Check it against something
Vitamin E (Mixed Tocopherols) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
94
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimBalanced vitamin E status
Prevents depletion of gamma and delta tocopherols
Enhanced cardiovascular protection
Gamma-tocopherol provides unique cardiovascular benefits
Superior anti-inflammatory effects
Gamma-tocopherol has stronger anti-inflammatory activity
Optimal cellular protection
Each tocopherol protects different membrane areas
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Glutathione
Master antioxidant & detox support
250-750mg
B
20%
Astaxanthin
Superior antioxidant & skin protection
4-12mg
B
20%
SAM-e
Mood support & liver health
400-800mg
A
70%
Plant Collagen
Vegan collagen support & antioxidants
2-5g
C
70%
Quercetin
Immune support & allergy relief
500-1000mg
B
5%
Every pair we checked
12 combinations scored by the engine
Vitamin E (Mixed Tocopherols) + Caffeine
No documented interaction either way
No known interaction
70
Vitamin E (Mixed Tocopherols) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Vitamin E (Mixed Tocopherols) + Whey Protein
No documented interaction either way
No known interaction
70
Vitamin E (Mixed Tocopherols) + Turmeric
No documented interaction either way
No known interaction
70
Vitamin E (Mixed Tocopherols) + Iron Sulfate
May reduce vitamin E effectiveness
Needs attention
76
Vitamin E (Mixed Tocopherols) + Selenium (Thyroid Support)
Very high vitamin C may reduce selenium absorption
Needs attention
82
Vitamin E (Mixed Tocopherols) + Lactase
Improved calcium absorption when consuming dairy
Works better together
82
Vitamin E (Mixed Tocopherols) + Bovine Collagen
Essential for collagen synthesis and cross-linking
Works better together
82
Vitamin E (Mixed Tocopherols) + DHA
Prevents oxidation of DHA and enhances stability
Works better together
82
Vitamin E (Mixed Tocopherols) + Vitamin D3
Regenerates oxidized vitamin E forms
Works better together
90
Vitamin E (Mixed Tocopherols) + Coenzyme Q10 (CoQ10)
Synergistic antioxidant protection
Works better together
90
Vitamin E (Mixed Tocopherols) + Calcium Carbonate
Essential for calcium absorption and utilization
Works better together
94
Dosage
Daily200-400 IU
Maintenance200-400 IU
Therapeutic400-800 IU
Maximum1000 IU
Typical ratioAlpha 25%, Beta 5%, Gamma 60%, Delta 10%
Upper limit
1000 mg NIH ODS
Before you take it
VeganYes
When to expect it
First Effects2-4 weeks for antioxidant status improvement
Peak Benefits8-12 weeks for cardiovascular and anti-inflammatory benefits
Deficiency DevelopmentYears due to extensive body stores
Toxicity OnsetMonths of very high doses
How to measure it
MarkerPlasma tocopherol profile (α, β, γ, δ)
OptimalAlpha: 12-42 μmol/L, Gamma: 2-8 μmol/L
Deficient belowAlpha: <12 μmol/L, Gamma: <1 μmol/L
FrequencyOnly if comprehensive vitamin E status needed
What people actually reported to the FDA
CAERS, 107 reports naming it as the suspectMost reported effects
Named as the suspect
107 reports
of 646 that mention it at all
Serious outcome
79%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event66
Hospitalization41
Visited a Health Care Provider31
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
Works better with
+
Vitamin C
Regenerates oxidized vitamin E forms
Reduces tocopherol radicals back to active forms · level A
+
Selenium
Works together in antioxidant defense
Complementary antioxidant pathways · level A
+
Coq10
Synergistic antioxidant protection
Different cellular compartments and mechanisms · level BWhat not to take with Vitamin E (Mixed Tocopherols)
!
Iron Supplements
May reduce vitamin E effectiveness
Iron catalyzes oxidation that depletes vitamin E · moderate significance
!
Alpha Tocopherol Alone
High alpha doses can deplete gamma-tocopherol
Competition for transport and tissue incorporation · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningIncreased bleeding risk
What to do: Monitor INR closely, limit dose
May interfere with treatment effectiveness
What to do: Discuss with oncologist before use
Available forms
Ranks 4 of 4 among vitamin e forms. Vitamin E (Gamma-Tocopherol) absorbs better — 85%. Compare all forms →
Mixed Tocopherols (natural ratios): Natural ratios, Complete protection, Prevents depletion, Superior to alpha alone
Food sources
Sunflower seeds
Mixed tocopherols: 35 mg/100g · 75
Almonds
Mixed tocopherols: 25 mg/100g · 70
Hazelnuts
Mixed tocopherols: 15 mg/100g · 70
Wheat germ oil
All four tocopherols: 149 mg/100g · 80
Too little
- Muscle weakness and atrophy
- Vision problems and retinal damage
- Immune system impairment
- Neurological problems
- Anemia (hemolytic)
- Reproductive issues
- Increased oxidative stress markers
Too much
- Increased bleeding tendency
- Nausea and diarrhea
- Fatigue and weakness
- Headache
- Blurred vision
- Skin rashes
- Interference with vitamin K
Who benefits most
health-conscious-individuals
Want most natural and complete vitamin E supplementation
200-400 IU daily
cardiovascular-risk
Gamma-tocopherol provides superior heart protection
200-400 IU daily
athletes
Comprehensive antioxidant protection from exercise stress
200-600 IU daily
anti-aging-focused
Complete antioxidant protection for longevity
200-400 IU daily
supplement-purists
Prefer natural ratios over synthetic single forms
200-400 IU dailyWhere to buy it
Look for Vitamin E (Mixed Tocopherols) at 200-400 IU per serving. The form that matters here is Mixed Tocopherols (natural ratios).
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How it works
- Alpha-tocopherol: primary membrane antioxidant
- Gamma-tocopherol: traps nitrogen radicals and peroxynitrite
- Delta-tocopherol: strongest in vitro antioxidant activity
- Beta-tocopherol: intermediate antioxidant activity
- Synergistic protection across cellular compartments
- Maintains natural tocopherol balance
Key findings
what the evidence supports- Gamma-tocopherol may be superior for cardiovascular health (AJCN 2003)
- Mixed tocopherols prevent alpha-tocopherol-induced gamma depletion
- Superior anti-inflammatory effects vs alpha-tocopherol alone
- Better reflects natural vitamin E intake patterns (Nutrition Reviews 2007)
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Vitamin E (Mixed Tocopherols)?
Documented effects: Comprehensive antioxidant protection; Balanced vitamin E status; Enhanced cardiovascular protection; Superior anti-inflammatory effects. All four tocopherols provide broader antioxidant coverage
How much Vitamin E (Mixed Tocopherols) should you take per day?
The common daily range is 200-400 IU. By goal — maintenance: 200-400 IU; therapeutic: 400-800 IU; maximum: 1000 IU; typical ratio: Alpha 25%, Beta 5%, Gamma 60%, Delta 10%.
When is the best time to take Vitamin E (Mixed Tocopherols)?
With fat meal. First effects are typically reported within 2-4 weeks for antioxidant status improvement.
What are the side effects of Vitamin E (Mixed Tocopherols)?
At excessive doses: Increased bleeding tendency, Nausea and diarrhea, Fatigue and weakness, Headache, Blurred vision. Safety rating at normal doses is 8 out of 10.
What should you not take with Vitamin E (Mixed Tocopherols)?
Separate it from Iron Supplements, Alpha Tocopherol Alone by two to four hours. May reduce vitamin E effectiveness
Does Vitamin E (Mixed Tocopherols) interact with medications?
Documented interactions with warfarin-blood-thinners, chemotherapy. Discuss these with a pharmacist before combining.
How much Vitamin E (Mixed Tocopherols) is too much?
The tolerable upper intake level is 1000 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: Increased bleeding tendency, Nausea and diarrhea, Fatigue and weakness.
How do you know if you need Vitamin E (Mixed Tocopherols)?
The marker is Plasma tocopherol profile (α, β, γ, δ), optimal range Alpha: 12-42 μmol/L, Gamma: 2-8 μmol/L. Common deficiency signs: Muscle weakness and atrophy, Vision problems and retinal damage, Immune system impairment, Neurological problems.