Master antioxidant protection
Most powerful antioxidant protecting cells from oxidative damage
Glutathione
Master antioxidant that supports detoxification, immune function, and cellular protection against oxidative stress
Scientific nameL-γ-glutamyl-L-cysteinylglycine
FormulaC10H17N3O6S
Molecular weight307.32 g/mol
CAS70-18-8
20
absorption score
9
safety / 10
60
USD per month
6
documented interactions
Check it against something
Glutathione with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- NAC (N-Acetyl-L-Cysteine)
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
82
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimEnhanced liver detoxification
Supports liver function and phase II detoxification pathways
Immune system enhancement
Supports immune cell function and reduces inflammation
Skin health and anti-aging
Improves skin appearance and may reduce signs of aging
Neurological protection
Protects brain cells and may support cognitive function
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Astaxanthin
Superior antioxidant & skin protection
4-12mg
B
20%
SAM-e
Mood support & liver health
400-800mg
A
70%
Plant Collagen
Vegan collagen support & antioxidants
2-5g
C
70%
Quercetin
Immune support & allergy relief
500-1000mg
B
5%
Potassium Citrate
Kidney stone prevention & pH balance
15-60 mEq
A
95%
Every pair we checked
12 combinations scored by the engine
Glutathione + Caffeine
No documented interaction either way
No known interaction
70
Glutathione + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Glutathione + Calcium Carbonate
No documented interaction either way
No known interaction
70
Glutathione + Whey Protein
No documented interaction either way
No known interaction
70
Glutathione + Lactase
No documented interaction either way
No known interaction
70
Glutathione + Bovine Collagen
No documented interaction either way
No known interaction
70
Glutathione + DHA
No documented interaction either way
No known interaction
70
Glutathione + Turmeric
No documented interaction either way
No known interaction
70
Glutathione + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Glutathione + NAC (N-Acetyl-L-Cysteine)
NAC provides cysteine for glutathione synthesis
Works better together
82
Glutathione + Selenium (Thyroid Support)
Essential for glutathione peroxidase enzyme function
Works better together
82
Glutathione + Vitamin D3
Enhanced antioxidant protection and glutathione recycling
Works better together
82
Dosage
Daily250-750mg
Antioxidant support250-500mg daily
Detoxification500-750mg daily
Immune support250-500mg daily
Therapeutic750-1500mg daily
When to expect it
First Effects2-4 weeks for antioxidant and detox benefits
Peak Benefits8-12 weeks for sustained cellular protection and health benefits
Deficiency DevelopmentGradual increase in oxidative stress and toxin accumulation
Toxicity OnsetVery rare, excellent safety profile
How to measure it
MarkerGlutathione levels (reduced/oxidized ratio)
OptimalHigh reduced glutathione with good GSH/GSSG ratio
Deficient belowLow glutathione levels or poor GSH/GSSG ratio
FrequencyEvery 6-12 months for antioxidant status monitoring
What people actually reported to the FDA
CAERS, 18 reports naming it as the suspectMost reported effects
Named as the suspect
18 reports
of 29 that mention it at all
Serious outcome
81%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event14
Visited Emergency Room7
Other Serious Outcome3
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Low 20 of 100 · poorly absorbed relative to other forms
Delivered daily
100 mg
Cost per 100 mg delivered
$2.00 comparative — uses the absorption score, not a measured percentage
Works better with
+
Nac
NAC provides cysteine for glutathione synthesis
NAC is precursor that boosts glutathione production · level A
+
Selenium
Essential for glutathione peroxidase enzyme function
Selenium required for glutathione antioxidant activity · level A
+
Vitamin C
Enhanced antioxidant protection and glutathione recycling
Vitamin C helps regenerate glutathione from oxidized form · level AWhat not to take with Glutathione
!
Alcohol Excess
Alcohol depletes glutathione rapidly
Alcohol metabolism consumes glutathione for detoxification · major significance
!
Acetaminophen Overdose
Acetaminophen overdose depletes glutathione dangerously
Toxic metabolite NAPQI consumes glutathione · critical significance
!
Heavy Metals
Heavy metals deplete glutathione stores
Metals bind glutathione reducing antioxidant capacity · major significanceMedication interactions
Discuss these with a pharmacist before combiningMay interfere with some chemotherapy effectiveness
What to do: Consult oncologist before use
Generally no significant drug interactions
What to do: Safe with most medications
Available forms
Liposomal Glutathione: Excellent absorption, High bioavailability, Effective delivery, Proven benefits
Reduced Glutathione (oral): Lower cost, Stable, Easy to take, Widely available
S-Acetyl Glutathione: Better absorption, More stable, Crosses cell membranes, Effective
Food sources
Asparagus
Highest vegetable source · 30
Spinach and broccoli
Good vegetable sources · 25
Avocado
Good fruit source · 25
Glutathione supplements
250-1000mg per dose · 20-80
Too little
- Increased oxidative stress and cellular damage
- Poor detoxification capacity and toxin accumulation
- Compromised immune function and frequent infections
- Accelerated aging and tissue damage
- Poor recovery from illness or stress
- Liver dysfunction and elevated liver enzymes
- Increased susceptibility to chronic diseases
Too much
- Excellent safety profile:
- Mild digestive upset with high doses
- Rare sulfur-like body odor
- Very rare allergic reactions
- Generally extremely well tolerated
Who benefits most
liver-detox-support
Essential for liver detoxification and protection
250-500mg daily (liposomal)
immune-system-support
Critical for optimal immune cell function
250-500mg daily
antioxidant-anti-aging
Master antioxidant for cellular protection and longevity
250-750mg daily
chronic-illness-oxidative-stress
Supports recovery from illness and reduces oxidative stress
500-1000mg daily
skin-health-beauty
May improve skin appearance and reduce aging signs
250-500mg dailyWhere to buy it
Look for Glutathione at 250-750mg per serving. The form that matters here is Liposomal Glutathione.
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What else affects it
Beyond other supplements
!
Alcohol excess
Alcohol depletes glutathione rapidly
Alcohol metabolism consumes glutathione for detoxification
!
Heavy metals
Heavy metals deplete glutathione stores
Metals bind glutathione reducing antioxidant capacityHow it works
- Primary intracellular antioxidant neutralizing free radicals
- Essential cofactor for glutathione peroxidase and S-transferase enzymes
- Regenerates vitamins C and E back to active forms
- Supports phase II liver detoxification pathways
- Essential for immune cell proliferation and function
- Protects mitochondria from oxidative damage
Key findings
what the evidence supports- Master antioxidant essential for cellular health and detoxification
- Critical for immune function and disease prevention
- Poor oral bioavailability unless in special forms like liposomal
- Excellent safety profile with wide range of health benefits
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Glutathione?
Documented effects: Master antioxidant protection; Enhanced liver detoxification; Immune system enhancement; Skin health and anti-aging. Most powerful antioxidant protecting cells from oxidative damage
How much Glutathione should you take per day?
The common daily range is 250-750mg. By goal — antioxidant support: 250-500mg daily; detoxification: 500-750mg daily; immune support: 250-500mg daily; therapeutic: 750-1500mg daily.
When is the best time to take Glutathione?
Empty stomach. First effects are typically reported within 2-4 weeks for antioxidant and detox benefits.
What are the side effects of Glutathione?
At excessive doses: Excellent safety profile:, Mild digestive upset with high doses, Rare sulfur-like body odor, Very rare allergic reactions, Generally extremely well tolerated. Safety rating at normal doses is 9 out of 10.
What should you not take with Glutathione?
Separate it from Alcohol Excess, Acetaminophen Overdose, Heavy Metals by two to four hours. Alcohol depletes glutathione rapidly
Does Glutathione interact with medications?
Documented interactions with chemotherapy, no-major-interactions. Discuss these with a pharmacist before combining.
How do you know if you need Glutathione?
The marker is Glutathione levels (reduced/oxidized ratio), optimal range High reduced glutathione with good GSH/GSSG ratio. Common deficiency signs: Increased oxidative stress and cellular damage, Poor detoxification capacity and toxin accumulation, Compromised immune function and frequent infections, Accelerated aging and tissue damage.