Antioxidant protection
Neutralizes free radicals in cell membranes
Vitamin E (Alpha-Tocopherol)
Primary fat-soluble antioxidant protecting cell membranes from oxidative damage
Scientific nameAlpha-Tocopherol
FormulaC29H50O2
Molecular weight430.71 g/mol
CAS59-02-9
75
absorption score
8
safety / 10
12
USD per month
5
documented interactions
Check it against something
Vitamin E (Alpha-Tocopherol) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
94
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimCardiovascular health
May reduce risk of heart disease
Immune support
Enhances immune cell function
Skin health
Protects skin from UV damage and aging
Neurological protection
May slow cognitive decline
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Glutathione
Master antioxidant & detox support
250-750mg
B
20%
Astaxanthin
Superior antioxidant & skin protection
4-12mg
B
20%
SAM-e
Mood support & liver health
400-800mg
A
70%
Plant Collagen
Vegan collagen support & antioxidants
2-5g
C
70%
Quercetin
Immune support & allergy relief
500-1000mg
B
5%
Every pair we checked
12 combinations scored by the engine
Vitamin E (Alpha-Tocopherol) + Caffeine
No documented interaction either way
No known interaction
70
Vitamin E (Alpha-Tocopherol) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Vitamin E (Alpha-Tocopherol) + Whey Protein
No documented interaction either way
No known interaction
70
Vitamin E (Alpha-Tocopherol) + Turmeric
No documented interaction either way
No known interaction
70
Vitamin E (Alpha-Tocopherol) + Iron Sulfate
May reduce vitamin E effectiveness
Needs attention
76
Vitamin E (Alpha-Tocopherol) + Selenium (Thyroid Support)
Very high vitamin C may reduce selenium absorption
Needs attention
82
Vitamin E (Alpha-Tocopherol) + Lactase
Improved calcium absorption when consuming dairy
Works better together
82
Vitamin E (Alpha-Tocopherol) + Bovine Collagen
Essential for collagen synthesis and cross-linking
Works better together
82
Vitamin E (Alpha-Tocopherol) + DHA
Prevents oxidation of DHA and enhances stability
Works better together
82
Vitamin E (Alpha-Tocopherol) + Vitamin D3
Regenerates oxidized vitamin E
Works better together
90
Vitamin E (Alpha-Tocopherol) + Coenzyme Q10 (CoQ10)
Synergistic antioxidant protection
Works better together
90
Vitamin E (Alpha-Tocopherol) + Calcium Carbonate
Essential for calcium absorption and utilization
Works better together
94
Dosage
Daily100-400 IU
Maintenance100-200 IU
Therapeutic200-400 IU
Maximum1000 IU
Toxic3200+ IU daily for months
Upper limit
1000 mg NIH ODS
Before you take it
VeganYes
When to expect it
First Effects2-4 weeks for antioxidant status improvement
Peak Benefits8-12 weeks for cardiovascular and immune benefits
Deficiency DevelopmentYears due to extensive body stores
Toxicity OnsetMonths of very high doses
How to measure it
MarkerAlpha-tocopherol
Optimal12-42 μmol/L (5.2-18.0 mg/L)
Deficient below12 μmol/L (5.2 mg/L)
FrequencyOnly if deficiency suspected or high-dose supplementation
What people actually reported to the FDA
CAERS, 107 reports naming it as the suspectMost reported effects
Named as the suspect
107 reports
of 646 that mention it at all
Serious outcome
79%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event66
Hospitalization41
Visited a Health Care Provider31
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
Works better with
+
Vitamin C
Regenerates oxidized vitamin E
Reduces vitamin E radicals back to active form · level A
+
Selenium
Works together in antioxidant defense
Complementary antioxidant pathways · level A
+
Coq10
Synergistic antioxidant protection
Different cellular compartments and mechanisms · level BWhat not to take with Vitamin E (Alpha-Tocopherol)
!
Iron Supplements
May reduce vitamin E effectiveness
Iron catalyzes oxidation that depletes vitamin E · moderate significance
!
Polyunsaturated Fats Excess
Increases vitamin E requirements
More substrate for lipid peroxidation · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningIncreased bleeding risk
What to do: Monitor INR closely, limit to 100 IU daily
May interfere with treatment effectiveness
What to do: Discuss with oncologist before use
Available forms
Ranks 2 of 4 among vitamin e forms. Vitamin E (Gamma-Tocopherol) absorbs better — 85%. Compare all forms →
d-Alpha-Tocopherol (natural): Higher bioactivity, Better retention, Preferred by body
dl-Alpha-Tocopherol (synthetic): Less expensive, Widely available, Stable
Mixed Tocopherols: Balanced ratio, Other tocopherols included, More natural
Food sources
Wheat germ oil
149 mg/100g · 80
Sunflower seeds
35 mg/100g · 75
Almonds
25 mg/100g · 70
Safflower oil
34 mg/100g · 80
Too little
- Muscle weakness and atrophy
- Vision problems and retinal damage
- Immune system impairment
- Neurological problems
- Anemia (hemolytic)
- Reproductive issues
- Increased oxidative stress markers
Too much
- Increased bleeding tendency
- Nausea and diarrhea
- Fatigue and weakness
- Headache
- Blurred vision
- Skin rashes
- Interference with vitamin K
Who benefits most
athletes
Higher oxidative stress from intense exercise
200-400 IU daily
smokers
Increased free radical exposure and oxidative stress
400-600 IU daily
elderly
Reduced antioxidant capacity and increased oxidative stress
200-400 IU daily
sun-exposed-workers
Increased UV exposure and skin oxidative damage
200-400 IU daily
heart-disease-risk
May help prevent LDL oxidation
200-400 IU dailyWhere to buy it
Look for Vitamin E (Alpha-Tocopherol) at 100-400 IU per serving. The form that matters here is d-Alpha-Tocopherol (natural).
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How it works
- Primary lipid-soluble antioxidant in cell membranes
- Breaks free radical chain reactions
- Protects polyunsaturated fatty acids from oxidation
- Modulates gene expression and cell signaling
- Supports immune cell membrane integrity
- Prevents LDL cholesterol oxidation
Key findings
what the evidence supports- Mixed results for cardiovascular disease prevention (Cochrane 2017)
- May reduce risk of age-related macular degeneration (JAMA 2001)
- Supports immune function in elderly (AJCN 2007)
- Controversial prostate cancer risk findings (SELECT trial 2011)
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Vitamin E (Alpha-Tocopherol)?
Documented effects: Antioxidant protection; Cardiovascular health; Immune support; Skin health. Neutralizes free radicals in cell membranes
How much Vitamin E (Alpha-Tocopherol) should you take per day?
The common daily range is 100-400 IU. By goal — maintenance: 100-200 IU; therapeutic: 200-400 IU; maximum: 1000 IU; toxic: 3200+ IU daily for months.
When is the best time to take Vitamin E (Alpha-Tocopherol)?
With fat meal. First effects are typically reported within 2-4 weeks for antioxidant status improvement.
What are the side effects of Vitamin E (Alpha-Tocopherol)?
At excessive doses: Increased bleeding tendency, Nausea and diarrhea, Fatigue and weakness, Headache, Blurred vision. Safety rating at normal doses is 8 out of 10.
What should you not take with Vitamin E (Alpha-Tocopherol)?
Separate it from Iron Supplements, Polyunsaturated Fats Excess by two to four hours. May reduce vitamin E effectiveness
Does Vitamin E (Alpha-Tocopherol) interact with medications?
Documented interactions with warfarin-blood-thinners, chemotherapy. Discuss these with a pharmacist before combining.
How much Vitamin E (Alpha-Tocopherol) is too much?
The tolerable upper intake level is 1000 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: Increased bleeding tendency, Nausea and diarrhea, Fatigue and weakness.
How do you know if you need Vitamin E (Alpha-Tocopherol)?
The marker is Alpha-tocopherol, optimal range 12-42 μmol/L (5.2-18.0 mg/L). Common deficiency signs: Muscle weakness and atrophy, Vision problems and retinal damage, Immune system impairment, Neurological problems.