Superior NAD+ boost
More effective at raising NAD+ levels than niacinamide or niacin
Vitamin B3 (Nicotinamide Riboside)
Advanced NAD+ precursor with superior bioavailability for cellular energy and anti-aging benefits
Scientific nameNicotinamide Riboside
FormulaC11H15N2O5
Molecular weight255.25 g/mol
CAS1341-23-7
95
absorption score
8
safety / 10
150
USD per month
5
documented interactions
Check it against something
Vitamin B3 (Nicotinamide Riboside) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Pterostilbene-Resveratrol Anti-Aging and Longevity Complex
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
86
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimEnhanced mitochondrial function
Improves cellular energy production and efficiency
DNA repair support
Activates sirtuins and PARP enzymes for cellular repair
Anti-aging effects
May slow cellular aging and improve healthspan
No side effects
No flushing, liver stress, or other B3 side effects
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Bone Broth Collagen
Gut healing & collagen support
20-40g powder
B
85%
Vitamin B7 (Biotin)
Hair, skin & nail health
300-5000 mcg
A
80%
Vitamin B3 (Niacinamide)
Energy & skin health (no flush)
100-1000 mg
A
88%
Marine Collagen
Anti-aging & skin health
5-15g
A
95%
Astaxanthin
Superior antioxidant & skin protection
4-12mg
B
20%
Every pair we checked
12 combinations scored by the engine
Vitamin B3 (Nicotinamide Riboside) + Caffeine
No documented interaction either way
No known interaction
70
Vitamin B3 (Nicotinamide Riboside) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Vitamin B3 (Nicotinamide Riboside) + Whey Protein
No documented interaction either way
No known interaction
70
Vitamin B3 (Nicotinamide Riboside) + Turmeric
No documented interaction either way
No known interaction
70
Vitamin B3 (Nicotinamide Riboside) + Resveratrol
Synergistic anti-aging and mitochondrial benefits
Works better together
78
Vitamin B3 (Nicotinamide Riboside) + Vitamin D3
Prevents arterial calcification from vitamin D
Works better together
78
Vitamin B3 (Nicotinamide Riboside) + Lactase
Improved calcium absorption when consuming dairy
Works better together
82
Vitamin B3 (Nicotinamide Riboside) + Bovine Collagen
Essential for collagen synthesis and cross-linking
Works better together
82
Vitamin B3 (Nicotinamide Riboside) + DHA
Prevents oxidation of DHA and enhances stability
Works better together
82
Vitamin B3 (Nicotinamide Riboside) + Pterostilbene-Resveratrol Anti-Aging and Longevity Complex
Both activate sirtuins and longevity pathways
Works better together
86
Vitamin B3 (Nicotinamide Riboside) + Coenzyme Q10 (CoQ10)
Both support mitochondrial energy production
Works better together
87
Vitamin B3 (Nicotinamide Riboside) + Calcium Carbonate
Essential for calcium absorption and utilization
Works better together
94
Dosage
Daily250-500 mg
Maintenance100-300 mg
Therapeutic300-1000 mg
Research doses1000-2000 mg
Cost effectiveConsider lower doses due to high cost
Upper limit
35 mg NIH ODS
Before you take it
VeganYes
When to expect it
First Effects1-2 weeks for energy improvements
Peak Benefits8-12 weeks for anti-aging and mitochondrial benefits
Deficiency DevelopmentSame as other B3 forms (weeks to months)
Toxicity OnsetNo known toxicity at current dosing levels
How to measure it
MarkerNAD+/NADH ratio or whole blood NAD+
OptimalAge-adjusted optimal levels
FrequencyEvery 3-6 months if optimizing anti-aging protocols
What people actually reported to the FDA
CAERS, 35 reports naming it as the suspectMost reported effects
Named as the suspect
35 reports
of 52 that mention it at all
Serious outcome
82%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event26
Visited Emergency Room15
Life Threatening8
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 95 of 100 · best absorbed form of this compound
Delivered daily
356.3 mg
Cost per 100 mg delivered
$1.40 comparative — uses the absorption score, not a measured percentage
Works better with
+
Pterostilbene
Both activate sirtuins and longevity pathways
Complementary sirtuin activation and NAD+ utilization · level B
+
Resveratrol
Synergistic anti-aging and mitochondrial benefits
Both support cellular energy and DNA repair · level B
+
Coq10
Both support mitochondrial energy production
Complementary roles in cellular respiration · level CWhat not to take with Vitamin B3 (Nicotinamide Riboside)
!
Alcohol Chronic
Depletes NAD+ and counteracts NR benefits
NAD+ consumption for alcohol metabolism · moderate significance
!
Cd38 Enzyme Activity
CD38 enzyme degrades NAD+ reducing NR effectiveness
Age-related CD38 increase limits NAD+ accumulation · moderate in aging significanceMedication interactions
Discuss these with a pharmacist before combiningTheoretical concern about DNA repair enhancement
What to do: Consult oncologist before use during cancer treatment
No known interactions but limited data
What to do: Monitor if using high doses
Available forms
Nicotinamide Riboside: Superior NAD+ boost, No side effects, Advanced technology, Anti-aging focus
Food sources
Milk (trace amounts)
<1mg per liter · 60
Brewer's yeast
Small amounts, variable · 50
Note: Meaningful amounts only available as supplement
Food sources negligible · 95
Too little
- Same as general B3 deficiency:
- Fatigue and low energy
- Poor cognitive function
- Reduced exercise tolerance
- Accelerated aging signs
- Metabolic dysfunction
Too much
- No known toxicity at current dosing levels
- Mild nausea in some users
- No flushing or liver stress
- Generally excellent safety profile
- Long-term effects unknown
Who benefits most
anti-aging-enthusiasts
Superior NAD+ boosting for longevity pathways
250-500 mg daily
biohackers-optimization
Cutting-edge supplement for cellular optimization
300-1000 mg daily
high-performers-executives
Enhanced cellular energy without side effects
250-500 mg daily
athletes-recovery-focused
Improved mitochondrial function and recovery
500-1000 mg daily
budget-unlimited-health
Want the most advanced B3 form regardless of cost
250-500 mg dailyWhere to buy it
Look for Vitamin B3 (Nicotinamide Riboside) at 250-500 mg per serving. The form that matters here is Nicotinamide Riboside.
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What else affects it
Beyond other supplements
!
Alcohol chronic
Depletes NAD+ and counteracts NR benefits
NAD+ consumption for alcohol metabolismHow it works
- Converted to NAD+ via nicotinamide riboside kinase pathway
- Bypasses rate-limiting steps of other NAD+ precursors
- Direct salvage pathway activation
- Enhanced cellular uptake compared to other B3 forms
- Supports sirtuin and PARP enzyme activation
- Improves mitochondrial biogenesis and function
Key findings
what the evidence supports- Raises NAD+ levels by 60% in humans (Nature Communications 2016)
- Improves mitochondrial function in aging (Cell Metabolism 2016)
- Safe and well-tolerated in human trials
- More effective than niacinamide for NAD+ boosting
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Vitamin B3 (Nicotinamide Riboside)?
Documented effects: Superior NAD+ boost; Enhanced mitochondrial function; DNA repair support; Anti-aging effects. More effective at raising NAD+ levels than niacinamide or niacin
How much Vitamin B3 (Nicotinamide Riboside) should you take per day?
The common daily range is 250-500 mg. By goal — maintenance: 100-300 mg; therapeutic: 300-1000 mg; research doses: 1000-2000 mg; cost effective: Consider lower doses due to high cost.
When is the best time to take Vitamin B3 (Nicotinamide Riboside)?
Morning with food. First effects are typically reported within 1-2 weeks for energy improvements.
What are the side effects of Vitamin B3 (Nicotinamide Riboside)?
At excessive doses: No known toxicity at current dosing levels, Mild nausea in some users, No flushing or liver stress, Generally excellent safety profile, Long-term effects unknown. Safety rating at normal doses is 8 out of 10.
What should you not take with Vitamin B3 (Nicotinamide Riboside)?
Separate it from Alcohol Chronic, Cd38 Enzyme Activity by two to four hours. Depletes NAD+ and counteracts NR benefits
Does Vitamin B3 (Nicotinamide Riboside) interact with medications?
Documented interactions with chemotherapy-agents, blood-thinners. Discuss these with a pharmacist before combining.
How much Vitamin B3 (Nicotinamide Riboside) is too much?
The tolerable upper intake level is 35 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: No known toxicity at current dosing levels, Mild nausea in some users, No flushing or liver stress.
How do you know if you need Vitamin B3 (Nicotinamide Riboside)?
The marker is NAD+/NADH ratio or whole blood NAD+, optimal range Age-adjusted optimal levels. Common deficiency signs: Same as general B3 deficiency:, Fatigue and low energy, Poor cognitive function, Reduced exercise tolerance.