Check a pair

Sulforaphane from Cruciferous Vegetables for Detox and Health

Powerful isothiocyanate compound from cruciferous vegetables that activates cellular detoxification pathways and provides potent anti-cancer and neuroprotective benefits

Scientific nameSulforaphane (1-isothiocyanato-4-methylsulfinylbutane) FormulaC6H11NOS2 Molecular weight177.29 g/mol CAS4478-93-7
70 absorption score
9 safety / 10
50 USD per month
5 documented interactions

Check it against something

Evidence level B

Sulforaphane from Cruciferous Vegetables for Detox and Health with:

Compatibility score 78 out of 100
78 out of 100
Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Powerful cellular detoxification and phase II enzyme activation

Activates body's natural detox pathways and removes toxins

Sulforaphane activates Nrf2 pathway inducing detoxification enzymes Evidence A-grade 1-4 weeks

Potent anti-cancer effects and tumor prevention

Reduces cancer risk and inhibits tumor growth

Multiple anti-cancer mechanisms including apoptosis induction and angiogenesis inhibition Evidence A-grade 4-24 weeks

Neuroprotection and cognitive health support

Protects brain cells and supports cognitive function

Crosses blood-brain barrier providing antioxidant and anti-inflammatory neuroprotection Evidence B-grade 4-16 weeks

Cardiovascular protection and heart health

Supports heart health and reduces cardiovascular disease risk

Anti-inflammatory and antioxidant effects protect cardiovascular system Evidence B-grade 8-24 weeks

Enhanced immune system function

Strengthens immune response and reduces inflammation

Modulates immune cell function and reduces pro-inflammatory cytokines Evidence B-grade 2-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Every pair we checked

12 combinations scored by the engine
Sulforaphane from Cruciferous Vegetables for Detox and Health + Caffeine No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Creatine Monohydrate No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Calcium Carbonate No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Whey Protein No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Lactase No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Bovine Collagen No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + DHA No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Turmeric No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Magnesium Oxide No documented interaction either way No known interaction 70
Sulforaphane from Cruciferous Vegetables for Detox and Health + Selenium (Thyroid Support) Enhanced phase II detoxification enzyme activity Works better together 78
Sulforaphane from Cruciferous Vegetables for Detox and Health + Vitamin D3 Synergistic antioxidant protection and cellular health Works better together 78

Dosage

Empty stomach
Daily10-40mg daily
Cellular protection10-20mg daily for general cellular health and protection
Cancer prevention20-40mg daily for cancer prevention and tumor suppression
Detoxification support15-30mg daily for enhanced detoxification
Maximum therapeuticGenerally safe up to 60mg daily with monitoring

When to expect it

First Effects1-2 weeks for detoxification and antioxidant effects
Peak Benefits4-16 weeks for optimal cellular protection and health benefits
Deficiency DevelopmentBenefits decrease without regular cruciferous vegetable intake
Toxicity OnsetGenerally very safe - mild effects with very high doses

How to measure it

$200-300
MarkerDetoxification markers, oxidative stress markers, inflammatory markers
OptimalEnhanced detoxification capacity, reduced oxidative stress
Deficient belowPoor detoxification markers, high oxidative stress
FrequencyEvery 6-12 months for detoxification and health monitoring

What actually reaches you

The label counts the carrier, your body does not
Absorption High 70 of 100 · absorbs well relative to other forms
Delivered daily 17.5 mg
Cost per 100 mg delivered $9.52 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented
+
Selenium

Enhanced phase II detoxification enzyme activity

Selenium supports glutathione peroxidase working with sulforaphane · level B
+
Vitamin C

Synergistic antioxidant protection and cellular health

Both provide antioxidant protection through different pathways · level B
+
Green Tea Egcg

Enhanced anti-cancer and cellular protection effects

Both provide complementary cellular protection mechanisms · level B

What not to take with Sulforaphane from Cruciferous Vegetables for Detox and Health

2 documented
!
Excessive Heat Cooking

High heat destroys myrosinase enzyme reducing sulforaphane formation

Heat inactivates enzyme needed for sulforaphane production · high significance
!
Goitrogens Excess

Very high cruciferous intake may affect thyroid function

Goitrogenic compounds in cruciferous vegetables · mild significance

Medication interactions

Discuss these with a pharmacist before combining
chemotherapy Moderate

May interfere with certain cancer treatments

What to do: Consult oncologist before use during treatment

blood-thinning-medications Minor

May enhance anticoagulant effects

What to do: Monitor bleeding parameters

thyroid-medications Minor

High doses may affect thyroid function

What to do: Monitor thyroid function tests

Available forms

bioavailability compared
Broccoli Sprout Extract (Standardized) 70
Glucoraphanin + Myrosinase Complex 85
Stabilized Sulforaphane 60
Whole Broccoli Sprout Powder 40

Broccoli Sprout Extract (Standardized): Standardized sulforaphane content, Research-backed, Consistent potency, Natural source

Glucoraphanin + Myrosinase Complex: Forms sulforaphane in body, Natural activation, Higher bioavailability, Stable storage

Stabilized Sulforaphane: Direct sulforaphane, Stable form, Predictable dosing, No enzyme needed

Whole Broccoli Sprout Powder: Whole food source, Natural form, Additional nutrients, Lower cost

Food sources

before you supplement
Broccoli sprouts Highest source: 10-100x more than mature broccoli · 70
Cruciferous vegetables (broccoli, kale, cabbage) Variable content, depends on preparation · 50
Sulforaphane supplement 10-40mg providing concentrated sulforaphane · 70

Too little

deficiency signs
  • Cruciferous compound deficiency symptoms:
  • Poor detoxification and toxin accumulation
  • Increased cancer risk and cellular damage
  • Reduced antioxidant protection
  • Compromised cellular defense mechanisms
  • Increased inflammation and oxidative stress
  • Poor adaptation to environmental stressors

Too much

toxicity signs
  • Sulforaphane excess symptoms (rare):
  • Digestive upset and gas
  • Nausea and stomach irritation
  • Potential thyroid effects (very high doses)
  • Skin rash (rare)
  • Headaches in sensitive individuals
  • Generally very safe compound

Who benefits most

cancer-prevention-high-risk

Powerful anti-cancer effects and tumor prevention

20-40mg daily for cancer prevention
environmental-toxin-exposure

Enhanced detoxification and protection from toxins

20-40mg daily for detox support
aging-adults-longevity

Cellular protection and healthy aging support

10-30mg daily for longevity benefits
cardiovascular-health-support

Heart protection and cardiovascular health

10-30mg daily for heart health
cognitive-neuroprotection

Brain protection and cognitive health support

10-30mg daily for neuroprotection

Where to buy it

compare forms first

Look for Sulforaphane from Cruciferous Vegetables for Detox and Health at 10-40mg daily per serving. The form that matters here is Broccoli Sprout Extract (Standardized).

Find on Amazon

Affiliate link — we may earn a commission at no cost to you.

What else affects it

Beyond other supplements
!
Excessive heat cooking

High heat destroys myrosinase enzyme reducing sulforaphane formation

Heat inactivates enzyme needed for sulforaphane production

How it works

  • Activates Nrf2 pathway inducing phase II detoxification enzymes
  • Induces apoptosis (programmed cell death) in cancer cells
  • Inhibits angiogenesis (blood vessel formation to tumors)
  • Reduces inflammation through NF-κB pathway inhibition
  • Provides powerful antioxidant protection against free radicals
  • Modulates gene expression for cellular protection and longevity

Key findings

what the evidence supports
  • Powerful anti-cancer effects in multiple cancer types
  • Significant detoxification and cellular protection benefits
  • Neuroprotective effects and cognitive health support
  • Generally safe with minimal side effects

Sources: NIH Examine.com · data reviewed 2026-08-01

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Sulforaphane from Cruciferous Vegetables for Detox and Health?

Documented effects: Powerful cellular detoxification and phase II enzyme activation; Potent anti-cancer effects and tumor prevention; Neuroprotection and cognitive health support; Cardiovascular protection and heart health. Activates body's natural detox pathways and removes toxins

How much Sulforaphane from Cruciferous Vegetables for Detox and Health should you take per day?

The common daily range is 10-40mg daily. By goal — cellular protection: 10-20mg daily for general cellular health and protection; cancer prevention: 20-40mg daily for cancer prevention and tumor suppression; detoxification support: 15-30mg daily for enhanced detoxification; maximum therapeutic: Generally safe up to 60mg daily with monitoring.

When is the best time to take Sulforaphane from Cruciferous Vegetables for Detox and Health?

Empty stomach. First effects are typically reported within 1-2 weeks for detoxification and antioxidant effects.

What are the side effects of Sulforaphane from Cruciferous Vegetables for Detox and Health?

At excessive doses: Sulforaphane excess symptoms (rare):, Digestive upset and gas, Nausea and stomach irritation, Potential thyroid effects (very high doses), Skin rash (rare). Safety rating at normal doses is 9 out of 10.

What should you not take with Sulforaphane from Cruciferous Vegetables for Detox and Health?

Separate it from Excessive Heat Cooking, Goitrogens Excess by two to four hours. High heat destroys myrosinase enzyme reducing sulforaphane formation

Does Sulforaphane from Cruciferous Vegetables for Detox and Health interact with medications?

Documented interactions with chemotherapy, blood-thinning-medications, thyroid-medications. Discuss these with a pharmacist before combining.

How do you know if you need Sulforaphane from Cruciferous Vegetables for Detox and Health?

The marker is Detoxification markers, oxidative stress markers, inflammatory markers, optimal range Enhanced detoxification capacity, reduced oxidative stress. Common deficiency signs: Cruciferous compound deficiency symptoms:, Poor detoxification and toxin accumulation, Increased cancer risk and cellular damage, Reduced antioxidant protection.

Taken for