Kidney stone prevention and management
Helps prevent kidney stone formation and may assist in stone breakdown
Chanca Piedra
Traditional Amazonian herb known as 'stone breaker' supporting kidney health, stone prevention, and urinary tract wellness through multiple mechanisms
Scientific namePhyllanthus niruri extract
FormulaRich in lignans, flavonoids, and alkaloids
Molecular weightVariable plant compounds g/mol
CASN/A - Natural plant extract
70
absorption score
7
safety / 10
25
USD per month
5
documented interactions
Check it against something
Chanca Piedra with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Potassium Citrate
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
75
out of 100
Works better together
Take together — same timing window amplifies the synergy.
What it does
mechanism and evidence for each claimKidney and liver protection
Provides hepatoprotective and nephroprotective effects
Urinary tract health support
Supports healthy urinary flow and urinary tract function
Anti-inflammatory kidney support
Reduces inflammation in kidney and urinary tract tissues
Traditional wellness and detox support
Supports overall wellness and natural detoxification processes
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Glutathione
Master antioxidant & detox support
250-750mg
B
20%
Astaxanthin
Superior antioxidant & skin protection
4-12mg
B
20%
SAM-e
Mood support & liver health
400-800mg
A
70%
Plant Collagen
Vegan collagen support & antioxidants
2-5g
C
70%
Quercetin
Immune support & allergy relief
500-1000mg
B
5%
Every pair we checked
12 combinations scored by the engine
Chanca Piedra + Caffeine
No documented interaction either way
No known interaction
70
Chanca Piedra + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Chanca Piedra + Vitamin D3
No documented interaction either way
No known interaction
70
Chanca Piedra + Calcium Carbonate
No documented interaction either way
No known interaction
70
Chanca Piedra + Whey Protein
No documented interaction either way
No known interaction
70
Chanca Piedra + Lactase
No documented interaction either way
No known interaction
70
Chanca Piedra + Bovine Collagen
No documented interaction either way
No known interaction
70
Chanca Piedra + DHA
No documented interaction either way
No known interaction
70
Chanca Piedra + Turmeric
No documented interaction either way
No known interaction
70
Chanca Piedra + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Chanca Piedra + Potassium Citrate
Enhanced kidney stone prevention through complementary mechanisms
Works better together
75
Chanca Piedra + Magnesium Oxide
Synergistic kidney stone prevention and mineral balance
Works better together
75
Dosage
Daily400-1000mg
Kidney stone prevention400-1000mg daily
Kidney health400-800mg daily
Urinary support400-600mg daily
Wellness support200-600mg daily
When to expect it
First Effects2-4 weeks for initial urinary tract and kidney benefits
Peak Benefits8-16 weeks for sustained kidney health and stone prevention
Deficiency DevelopmentNot applicable - chanca piedra is not an essential nutrient
Toxicity OnsetRare with proper dosing, mainly blood sugar and pressure effects
How to measure it
MarkerKidney function (creatinine, BUN), liver enzymes, blood glucose
OptimalNormal kidney and liver function, stable blood glucose
Deficient belowImpaired kidney function, elevated liver enzymes
FrequencyEvery 3-6 months for kidney and liver function monitoring
What people actually reported to the FDA
CAERS, 6 reports naming it as the suspectMost reported effects
Named as the suspect
6 reports
of 6 that mention it at all
Serious outcome
75%
hospitalisation, emergency room or worse
Hospitalization4
Other Serious or Important Medical Event4
Visited a Health Care Provider3
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
High 70 of 100 · absorbs well relative to other forms
Delivered daily
490 mg
Cost per 100 mg delivered
$0.17 comparative — uses the absorption score, not a measured percentage
Works better with
+
Adequate Hydration
Essential for chanca piedra effectiveness and kidney health
Proper hydration supports herb's diuretic and stone prevention effects · level A
+
Potassium Citrate
Enhanced kidney stone prevention through complementary mechanisms
Both work via different pathways to prevent stone formation · level C
+
Magnesium
Synergistic kidney stone prevention and mineral balance
Both provide kidney protective effects through different mechanisms · level CWhat not to take with Chanca Piedra
!
High Oxalate Foods
High oxalate intake may counteract stone prevention benefits
Excess dietary oxalate increases stone formation risk · moderate significance
!
Dehydration
Inadequate fluids reduce herb effectiveness and kidney health
Concentrated urine reduces herb benefits and increases stone risk · high significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance blood sugar lowering effects
What to do: Monitor blood glucose closely
May enhance hypotensive effects
What to do: Monitor blood pressure
Available forms
Standardized Chanca Piedra Extract (Phyllanthus niruri): Traditional use history, Multiple mechanisms, Kidney and liver benefits, Natural approach
Food sources
Standardized chanca piedra extract
400-1000mg standardized extract · 70
Chanca piedra tea
Traditional preparation · 50
Whole chanca piedra herb
Traditional powdered herb · 45
Chanca piedra tincture
Liquid herbal extract · 60
Too little
- No deficiency symptoms as chanca piedra is not essential:
- Increased susceptibility to kidney stone formation
- Higher kidney inflammation and oxidative stress
- Reduced natural kidney protection mechanisms
- Poor urinary tract health and function
- Compromised liver and kidney detoxification
Too much
- Generally safe with some considerations:
- Blood sugar lowering effects in diabetics
- Blood pressure reduction in hypotensive individuals
- Mild digestive upset with high doses
- Should be used with caution in diabetes and hypotension
Who benefits most
kidney-stone-prevention
Natural kidney stone prevention and formation inhibition
400-1000mg daily
kidney-health-support
General kidney health protection and function support
400-800mg daily
urinary-tract-wellness
Urinary tract health and anti-inflammatory support
400-600mg daily
liver-kidney-detox
Traditional detoxification and organ protection support
400-800mg daily
traditional-wellness
Overall wellness and traditional herbal health support
200-600mg dailyWhere to buy it
Look for Chanca Piedra at 400-1000mg per serving. The form that matters here is Standardized Chanca Piedra Extract (Phyllanthus niruri).
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What else affects it
Beyond other supplements
+
Adequate hydration
Essential for chanca piedra effectiveness and kidney health
Proper hydration supports herb's diuretic and stone prevention effects
!
High oxalate foods
High oxalate intake may counteract stone prevention benefits
Excess dietary oxalate increases stone formation risk
!
Dehydration
Inadequate fluids reduce herb effectiveness and kidney health
Concentrated urine reduces herb benefits and increases stone riskHow it works
- Inhibits calcium oxalate crystal nucleation, growth, and aggregation
- Anti-inflammatory effects reduce kidney and urinary tract inflammation
- Antioxidant compounds protect kidney tissue from oxidative damage
- Diuretic effects support healthy urine flow and toxin elimination
- Antimicrobial properties support urinary tract health and infection prevention
- Hepatoprotective effects support liver detoxification and overall wellness
Key findings
what the evidence supports- Good research on kidney stone prevention and crystal inhibition
- Traditional use evidence for kidney and liver health
- Moderate clinical evidence for anti-inflammatory kidney effects
- Generally safe with monitoring for blood sugar and pressure effects
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Chanca Piedra?
Documented effects: Kidney stone prevention and management; Kidney and liver protection; Urinary tract health support; Anti-inflammatory kidney support. Helps prevent kidney stone formation and may assist in stone breakdown
How much Chanca Piedra should you take per day?
The common daily range is 400-1000mg. By goal — kidney stone prevention: 400-1000mg daily; kidney health: 400-800mg daily; urinary support: 400-600mg daily; wellness support: 200-600mg daily.
When is the best time to take Chanca Piedra?
With meals. First effects are typically reported within 2-4 weeks for initial urinary tract and kidney benefits.
What are the side effects of Chanca Piedra?
At excessive doses: Generally safe with some considerations:, Blood sugar lowering effects in diabetics, Blood pressure reduction in hypotensive individuals, Mild digestive upset with high doses, Should be used with caution in diabetes and hypotension. Safety rating at normal doses is 7 out of 10.
What should you not take with Chanca Piedra?
Separate it from High Oxalate Foods, Dehydration by two to four hours. High oxalate intake may counteract stone prevention benefits
Does Chanca Piedra interact with medications?
Documented interactions with diabetes-medications, blood-pressure-medications. Discuss these with a pharmacist before combining.
How do you know if you need Chanca Piedra?
The marker is Kidney function (creatinine, BUN), liver enzymes, blood glucose, optimal range Normal kidney and liver function, stable blood glucose. Common deficiency signs: No deficiency symptoms as chanca piedra is not essential:, Increased susceptibility to kidney stone formation, Higher kidney inflammation and oxidative stress, Reduced natural kidney protection mechanisms.