Yohimbine

Alkaloid stimulant that enhances fat burning, increases energy, and supports athletic performance through alpha-2 antagonism

Scientific namePausinystalia johimbe FormulaC21H26N2O3 Molecular weight354.44 g/mol CAS146-48-5

85 absorption score

5 safety / 10

45 USD per month

6 documented interactions

Check it against something

Evidence level B

Yohimbine with:

78 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Fat burning and lipolysis enhancement

Significantly increases fat burning, especially stubborn fat areas

Alpha-2 adrenergic receptor antagonism increases norepinephrine and fat oxidation Evidence B-grade 2-8 weeks for fat burning benefits

Energy and alertness enhancement

Increases energy levels, alertness, and mental focus

CNS stimulation through norepinephrine and dopamine modulation Evidence B-grade 30-60 minutes for acute energy effects

Athletic performance and endurance improvement

Enhances athletic performance and exercise capacity

Increased sympathetic nervous system activity and fat utilization Evidence C-grade 1-4 weeks for performance benefits

Erectile function and libido support

Traditional use for erectile dysfunction and libido enhancement

Increased blood flow and alpha-2 receptor blockade Evidence B-grade 2-8 weeks for sexual health benefits

Appetite suppression and weight management

Reduces appetite and supports weight management efforts

CNS effects on appetite control and satiety hormones Evidence C-grade 1-4 weeks for appetite effects

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Ashwagandha Stress management & energy 300-600mg A 75% Vitamin B12 (Cyanocobalamin) Energy & nerve support 250-1000 mcg A 70% Coenzyme Q10 (CoQ10) Heart health & cellular energy 100-200mg A 10% Phosphorus Bone health & energy metabolism 700-1250mg A 80% Vitamin B3 (Niacinamide) Energy & skin health (no flush) 100-1000 mg A 88% Berberine for Advanced Glucose Control and Metabolic Support Blood sugar control & metabolic support 1500mg daily (500mg x3) A 60%

Every pair we checked

12 combinations scored by the engine

Yohimbine + Creatine Monohydrate No documented interaction either way No known interaction 70

Yohimbine + Vitamin D3 No documented interaction either way No known interaction 70

Yohimbine + Calcium Carbonate No documented interaction either way No known interaction 70

Yohimbine + Whey Protein No documented interaction either way No known interaction 70

Yohimbine + Lactase No documented interaction either way No known interaction 70

Yohimbine + Bovine Collagen No documented interaction either way No known interaction 70

Yohimbine + DHA No documented interaction either way No known interaction 70

Yohimbine + Turmeric No documented interaction either way No known interaction 70

Yohimbine + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70

Yohimbine + Green Tea Extract (EGCG) Enhanced fat oxidation and metabolism Works better together 75

Yohimbine + L-Tyrosine Enhanced neurotransmitter support and focus Works better together 75

Yohimbine + Caffeine Enhanced fat burning and energy effects Works better together 78

Dosage

Empty stomach morning

Daily5-20 mg

Fat burning5-20 mg daily on empty stomach

Pre workout5-10 mg 30 minutes before exercise

Erectile function5-10 mg 2-3 times daily

Energy boost5-10 mg as needed

Before you take it

Pregnancyavoid

When to expect it

First Effects30-60 minutes for acute energy and stimulant effects

Peak Benefits2-8 weeks for maximum fat burning and performance benefits

Deficiency DevelopmentGradual return to baseline energy and fat burning

Toxicity OnsetPossible with high doses - cardiovascular and anxiety risks

How to measure it

$150-300

MarkerBlood pressure, heart rate, stress hormones, lipid profile

OptimalNormal blood pressure and heart rate, improved body composition

Deficient belowNot applicable - not essential nutrient

FrequencyMonitor cardiovascular parameters every 4-6 weeks

What actually reaches you

The label counts the carrier, your body does not

Absorption Very high 85 of 100 · best absorbed form of this compound

Delivered daily 10.6 mg

Cost per 100 mg delivered $14.12 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Caffeine

Enhanced fat burning and energy effects

Synergistic stimulant and lipolytic effects · level B

Green Tea Extract

Enhanced fat oxidation and metabolism

Both support fat burning through different pathways · level C

Tyrosine

Enhanced neurotransmitter support and focus

Tyrosine supports dopamine and norepinephrine synthesis · level C

What not to take with Yohimbine

3 documented

Alpha 2 Agonists

Alpha-2 agonists directly counteract yohimbine effects

Opposite receptor actions · major significance

Food Carbohydrates

Food and carbs significantly reduce yohimbine effectiveness

Insulin response blocks fat burning and alpha-2 effects · major significance

Beta Blockers

Beta-blockers may reduce yohimbine's cardiovascular effects

Blocks beta-adrenergic stimulation · moderate significance

Medication interactions

Discuss these with a pharmacist before combining

antidepressants-maoi Major

Dangerous interaction with MAO inhibitors

What to do: Avoid combination - serious hypertensive crisis risk

blood-pressure-medications Moderate

May counteract blood pressure medications

What to do: Monitor blood pressure closely

stimulant-medications Moderate

May enhance stimulant effects and side effects

What to do: Monitor for excessive stimulation and cardiovascular effects

Available forms

bioavailability compared

Yohimbine HCl 85

Yohimbe bark extract 60

Alpha-yohimbine (rauwolscine) 80

Yohimbine HCl: Standardized potency, Proven research, Predictable effects, Cost-effective

Yohimbe bark extract: Natural whole extract, Traditional use, Additional compounds, Lower cost

Alpha-yohimbine (rauwolscine): Longer half-life, Smoother effects, Less anxiety, Better tolerance

Food sources

before you supplement

Yohimbe tree bark Natural source - not commonly consumed · 40

Not found in common foods Supplementation required for therapeutic effects · N/A

Traditional herbal preparations Variable yohimbine content · 30

Yohimbine supplements 2.5-50 mg per capsule · 80-85

Too little

deficiency signs

Yohimbine is not essential but inadequate fat burning support may cause:
Difficulty losing fat, especially in stubborn areas
Reduced energy and alertness
Poor athletic performance and endurance
Slow metabolism and fat oxidation
Reduced libido and sexual function
Increased appetite and weight gain

Too much

toxicity signs

Yohimbine toxicity symptoms:
Cardiovascular effects including hypertension and arrhythmias
Severe anxiety and panic attacks
Insomnia and sleep disturbances
Nausea and gastrointestinal upset
Headaches and dizziness
Potential for dangerous interactions with medications

Who benefits most

fat-loss-body-composition

Proven benefits for fat burning and body composition improvement

5-20 mg daily on empty stomach

athletes-performance

May enhance athletic performance and energy levels

5-10 mg pre-workout

erectile-dysfunction

Traditional use for erectile dysfunction and libido support

5-10 mg 2-3 times daily

energy-enhancement

Provides stimulant effects and energy boost

5-10 mg as needed

weight-management

Supports weight loss through appetite suppression and fat burning

5-20 mg daily

Where to buy it

compare forms first

Look for Yohimbine at 5-20 mg per serving. The form that matters here is Yohimbine HCl.

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What else affects it

Beyond other supplements

Food carbohydrates

Food and carbs significantly reduce yohimbine effectiveness

Insulin response blocks fat burning and alpha-2 effects

How it works

Alpha-2 adrenergic receptor antagonism increases norepinephrine release
Enhanced lipolysis and fat oxidation through increased sympathetic activity
CNS stimulation through norepinephrine and dopamine modulation
Increased blood flow through alpha-2 receptor blockade
MAO inhibition may enhance neurotransmitter availability
Appetite suppression through CNS effects on satiety centers

Key findings

what the evidence supports

Good evidence for fat burning and body composition benefits
Proven stimulant effects and energy enhancement
Significant cardiovascular and anxiety risks at high doses
Must be taken on empty stomach for effectiveness

Sources: NIH Examine.com · data reviewed 2026-08-01

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Yohimbine?

Documented effects: Fat burning and lipolysis enhancement; Energy and alertness enhancement; Athletic performance and endurance improvement; Erectile function and libido support. Significantly increases fat burning, especially stubborn fat areas

How much Yohimbine should you take per day?

The common daily range is 5-20 mg. By goal — fat burning: 5-20 mg daily on empty stomach; pre workout: 5-10 mg 30 minutes before exercise; erectile function: 5-10 mg 2-3 times daily; energy boost: 5-10 mg as needed.

When is the best time to take Yohimbine?

Empty stomach morning. First effects are typically reported within 30-60 minutes for acute energy and stimulant effects.

What are the side effects of Yohimbine?

At excessive doses: Yohimbine toxicity symptoms:, Cardiovascular effects including hypertension and arrhythmias, Severe anxiety and panic attacks, Insomnia and sleep disturbances, Nausea and gastrointestinal upset. Safety rating at normal doses is 5 out of 10.

What should you not take with Yohimbine?

Separate it from Alpha 2 Agonists, Food Carbohydrates, Beta Blockers by two to four hours. Alpha-2 agonists directly counteract yohimbine effects

Does Yohimbine interact with medications?

Documented interactions with antidepressants-maoi, blood-pressure-medications, stimulant-medications. Discuss these with a pharmacist before combining.

How do you know if you need Yohimbine?

The marker is Blood pressure, heart rate, stress hormones, lipid profile, optimal range Normal blood pressure and heart rate, improved body composition. Common deficiency signs: Yohimbine is not essential but inadequate fat burning support may cause:, Difficulty losing fat, especially in stubborn areas, Reduced energy and alertness, Poor athletic performance and endurance.

Taken for

62 Energy & Metabolism

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