Vitamin B6 (Pyridoxamine)

Amine form of vitamin B6 with unique anti-glycation properties and metabolic benefits

Scientific namePyridoxamine FormulaC8H12N2O2 Molecular weight168.19 g/mol CAS85-87-0

85 absorption score

8 safety / 10

50 USD per month

5 documented interactions

Check it against something

Evidence level A

Vitamin B6 (Pyridoxamine) with:

90 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Anti-glycation effects

Prevents protein glycation and advanced glycation end products (AGEs)

Scavenges reactive carbonyls and prevents protein cross-linking Evidence B-grade 4-8 weeks

Diabetic complication prevention

May reduce diabetic kidney, eye, and nerve damage

Prevents AGE formation in diabetic tissues Evidence B-grade 8-16 weeks

Enhanced glucose metabolism

Superior glucose control compared to other B6 forms

Unique metabolic pathways and enzyme interactions Evidence C-grade 4-8 weeks

Anti-aging properties

Protects against age-related protein damage

Prevents protein glycation and oxidative damage Evidence C-grade 8-16 weeks

Standard B6 functions

All typical vitamin B6 benefits plus unique advantages

Converted to PLP for standard B6 enzyme functions Evidence A-grade 2-6 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Ashwagandha Stress management & energy 300-600mg A 75% Vitamin B12 (Cyanocobalamin) Energy & nerve support 250-1000 mcg A 70% Coenzyme Q10 (CoQ10) Heart health & cellular energy 100-200mg A 10% Phosphorus Bone health & energy metabolism 700-1250mg A 80% Vitamin B3 (Niacinamide) Energy & skin health (no flush) 100-1000 mg A 88% Berberine for Advanced Glucose Control and Metabolic Support Blood sugar control & metabolic support 1500mg daily (500mg x3) A 60%

Every pair we checked

12 combinations scored by the engine

Vitamin B6 (Pyridoxamine) + Caffeine No documented interaction either way No known interaction 70

Vitamin B6 (Pyridoxamine) + Creatine Monohydrate No documented interaction either way No known interaction 70

Vitamin B6 (Pyridoxamine) + Whey Protein No documented interaction either way No known interaction 70

Vitamin B6 (Pyridoxamine) + Turmeric No documented interaction either way No known interaction 70

Vitamin B6 (Pyridoxamine) + Chromium GTF Both support glucose metabolism and insulin function Works better together 78

Vitamin B6 (Pyridoxamine) + Vitamin D3 Prevents arterial calcification from vitamin D Works better together 78

Vitamin B6 (Pyridoxamine) + Lactase Improved calcium absorption when consuming dairy Works better together 82

Vitamin B6 (Pyridoxamine) + Bovine Collagen Essential for collagen synthesis and cross-linking Works better together 82

Vitamin B6 (Pyridoxamine) + DHA Prevents oxidation of DHA and enhances stability Works better together 82

Vitamin B6 (Pyridoxamine) + Alpha-Lipoic Acid (ALA) Both prevent glycation and support glucose metabolism Works better together 90

Vitamin B6 (Pyridoxamine) + Magnesium Oxide Required for pyridoxamine kinase enzyme function Works better together 94

Vitamin B6 (Pyridoxamine) + Calcium Carbonate Essential for calcium absorption and utilization Works better together 94

Dosage

With meals

Daily25-200 mg

Maintenance25-50 mg

Therapeutic50-200 mg

Anti glycation100-300 mg

Diabetic support150-400 mg (medical supervision)

Upper limit 100 mg NIH ODS

Before you take it

VeganYes

When to expect it

First Effects2-4 weeks for standard B6 benefits

Peak Benefits8-16 weeks for anti-glycation and metabolic benefits

Deficiency Development4-6 weeks with inadequate B6 intake

Toxicity OnsetRare, similar safety profile to other B6 forms

How to measure it

$80-150

MarkerPlasma PLP, glucose, HbA1c, or AGE levels

OptimalPLP >20 nmol/L, improved glucose control

FrequencyEvery 3-6 months if using for glucose control

What actually reaches you

The label counts the carrier, your body does not

Absorption Very high 85 of 100 · best absorbed form of this compound

Delivered daily 95.6 mg

Cost per 100 mg delivered $1.74 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Alpha Lipoic Acid

Both prevent glycation and support glucose metabolism

Complementary anti-glycation and antioxidant effects · level B

Chromium

Both support glucose metabolism and insulin function

Complementary glucose control mechanisms · level B

Magnesium

Required for pyridoxamine kinase enzyme function

Cofactor for B6 activation to active forms · level A

What not to take with Vitamin B6 (Pyridoxamine)

2 documented

High Glucose

High glucose environments increase pyridoxamine utilization

More anti-glycation activity needed with high glucose · moderate significance

Alcohol

Depletes B6 and interferes with metabolism

Inhibits B6 enzymes and increases degradation · major significance

Medication interactions

Discuss these with a pharmacist before combining

diabetes-medications Beneficial

May enhance glucose control

What to do: Monitor blood glucose for improvements

levodopa Major

B6 can reduce levodopa effectiveness

What to do: Avoid B6 supplements with levodopa monotherapy

anticonvulsants Moderate

Some seizure medications may deplete B6

What to do: Monitor B6 status

Available forms

bioavailability compared

Pyridoxamine (PM) 85

Pyridoxamine (PM): Anti-glycation effects, Diabetic benefits, Advanced properties, Superior for glucose metabolism

Food sources

before you supplement

Pyridoxamine found in limited food sources Primarily in animal products · 85

Fish and meat Small amounts, variable · 80

Note: Meaningful amounts mainly from supplements Food sources insufficient for therapeutic effects · 85

Too little

deficiency signs

Same as general B6 deficiency:
Depression and mood changes
Confusion and cognitive problems
Weakened immune system
Anemia and fatigue
Plus potential for increased glycation damage
Accelerated aging processes

Too much

toxicity signs

Similar to other B6 forms:
Peripheral neuropathy (very high doses)
Skin sensitivity
Digestive upset
Generally safe profile
No unique toxicity concerns identified

Who benefits most

diabetics-blood-sugar-control

Superior glucose metabolism and diabetic complication prevention

50-200 mg daily

anti-aging-focused

Unique anti-glycation properties for healthy aging

25-100 mg daily

advanced-supplementation

Want cutting-edge B6 form with unique benefits

25-150 mg daily

metabolic-syndrome

Enhanced glucose metabolism and metabolic support

50-150 mg daily

kidney-health-protection

May protect against AGE-related kidney damage

50-200 mg daily

Where to buy it

compare forms first

Look for Vitamin B6 (Pyridoxamine) at 25-200 mg per serving. The form that matters here is Pyridoxamine (PM).

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What else affects it

Beyond other supplements

Alcohol

Depletes B6 and interferes with metabolism

Inhibits B6 enzymes and increases degradation

How it works

Converted to pyridoxamine phosphate (PMP) and then PLP
Scavenges reactive carbonyls preventing protein glycation
Inhibits advanced glycation end product (AGE) formation
Superior for certain aminotransferase reactions
Unique metabolic pathways not shared by other B6 forms
Enhanced glucose metabolism through specialized enzymes

Key findings

what the evidence supports

Superior anti-glycation effects vs other B6 forms (research studies)
Potential benefits for diabetic complications (animal and preliminary human studies)
Enhanced glucose metabolism compared to pyridoxine
May be more bioavailable and effective than standard B6 forms

Sources: NIH Examine.com · data reviewed 2026-08-01

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Vitamin B6 (Pyridoxamine)?

Documented effects: Anti-glycation effects; Diabetic complication prevention; Enhanced glucose metabolism; Anti-aging properties. Prevents protein glycation and advanced glycation end products (AGEs)

How much Vitamin B6 (Pyridoxamine) should you take per day?

The common daily range is 25-200 mg. By goal — maintenance: 25-50 mg; therapeutic: 50-200 mg; anti glycation: 100-300 mg; diabetic support: 150-400 mg (medical supervision).

When is the best time to take Vitamin B6 (Pyridoxamine)?

With meals. First effects are typically reported within 2-4 weeks for standard B6 benefits.

What are the side effects of Vitamin B6 (Pyridoxamine)?

At excessive doses: Similar to other B6 forms:, Peripheral neuropathy (very high doses), Skin sensitivity, Digestive upset, Generally safe profile. Safety rating at normal doses is 8 out of 10.

What should you not take with Vitamin B6 (Pyridoxamine)?

Separate it from High Glucose, Alcohol by two to four hours. High glucose environments increase pyridoxamine utilization

Does Vitamin B6 (Pyridoxamine) interact with medications?

Documented interactions with diabetes-medications, levodopa, anticonvulsants. Discuss these with a pharmacist before combining.

How much Vitamin B6 (Pyridoxamine) is too much?

The tolerable upper intake level is 100 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: Similar to other B6 forms:, Peripheral neuropathy (very high doses), Skin sensitivity.

How do you know if you need Vitamin B6 (Pyridoxamine)?

The marker is Plasma PLP, glucose, HbA1c, or AGE levels, optimal range PLP >20 nmol/L, improved glucose control. Common deficiency signs: Same as general B6 deficiency:, Depression and mood changes, Confusion and cognitive problems, Weakened immune system.

Taken for

62 Energy & Metabolism

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