Enhanced mitochondrial health and function
Improves mitochondrial quality and energy production
Urolithin A for Mitochondrial Health and Cellular Energy
Revolutionary postbiotic compound that enhances mitochondrial health through mitophagy activation, improving cellular energy production and supporting healthy aging
Scientific nameUrolithin A (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one)
FormulaC13H8O4
Molecular weight228.2 g/mol
CAS1143-70-0
85
absorption score
7
safety / 10
200
USD per month
5
documented interactions
Check it against something
Urolithin A for Mitochondrial Health and Cellular Energy with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- PQQ (Pyrroloquinoline Quinone)
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimIncreased cellular energy and ATP production
Boosts cellular energy levels and reduces fatigue
Improved muscle endurance and recovery
Enhances muscle energy metabolism and reduces exercise fatigue
Anti-aging and longevity support
Supports healthy aging through mitochondrial optimization
Cognitive function and brain health
Supports brain energy metabolism and cognitive performance
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Ashwagandha
Stress management & energy
300-600mg
A
75%
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Vitamin B3 (Niacinamide)
Energy & skin health (no flush)
100-1000 mg
A
88%
Berberine for Advanced Glucose Control and Metabolic Support
Blood sugar control & metabolic support
1500mg daily (500mg x3)
A
60%
Every pair we checked
12 combinations scored by the engine
Urolithin A for Mitochondrial Health and Cellular Energy + Caffeine
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Vitamin D3
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Calcium Carbonate
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Whey Protein
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Lactase
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Bovine Collagen
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + DHA
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + Turmeric
No documented interaction either way
No known interaction
70
Urolithin A for Mitochondrial Health and Cellular Energy + PQQ (Pyrroloquinoline Quinone)
Synergistic mitochondrial biogenesis and protection
Works better together
78
Urolithin A for Mitochondrial Health and Cellular Energy + Coenzyme Q10 (CoQ10)
Enhanced mitochondrial electron transport and energy production
Works better together
82
Urolithin A for Mitochondrial Health and Cellular Energy + Magnesium Oxide
Enhanced ATP synthesis and mitochondrial function
Works better together
82
Dosage
Daily500-1000mg daily
Mitochondrial support500mg daily for basic mitochondrial enhancement
Energy enhancement500-1000mg daily for improved cellular energy
Athletic performance1000mg daily for endurance and recovery support
Maximum researchGenerally safe up to 1000mg daily based on studies
When to expect it
First Effects2-4 weeks for energy and cellular improvements
Peak Benefits8-16 weeks for optimal mitochondrial and health benefits
Deficiency DevelopmentNatural production varies by individual
Toxicity OnsetGenerally safe - minimal toxicity data
How to measure it
MarkerMitochondrial function markers, cellular energy metabolites, oxidative stress markers
OptimalImproved mitochondrial markers, enhanced cellular energy
Deficient belowPoor mitochondrial function, low cellular energy
FrequencyEvery 6-12 months for mitochondrial health monitoring
What people actually reported to the FDA
CAERS, 1 reports naming it as the suspectMost reported effects
Named as the suspect
1 reports
of 2 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event1
Visited Emergency Room1
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 85 of 100 · best absorbed form of this compound
Delivered daily
637.5 mg
Cost per 100 mg delivered
$1.05 comparative — uses the absorption score, not a measured percentage
Works better with
+
Coq10 Ubiquinol
Enhanced mitochondrial electron transport and energy production
Both support mitochondrial respiratory chain function · level A
+
Pqq
Synergistic mitochondrial biogenesis and protection
Both promote new mitochondria formation · level B
+
Magnesium
Enhanced ATP synthesis and mitochondrial function
Magnesium required for ATP production enzymes · level AWhat not to take with Urolithin A for Mitochondrial Health and Cellular Energy
!
Excessive Oxidative Stress
High oxidative stress may overwhelm mitochondrial benefits
Oxidative damage counteracts mitochondrial improvements · moderate significance
!
Mitochondrial Toxins
Exposure to mitochondrial toxins reduces effectiveness
Toxins damage mitochondria faster than repair · high significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance or interfere with mitochondrial medications
What to do: Consult healthcare provider
Limited data on interaction potential
What to do: Monitor for bleeding changes
May affect cellular energy metabolism
What to do: Monitor blood sugar levels
Available forms
Synthetic Urolithin A: Direct bioavailable form, Standardized dosing, Research-backed, Consistent effects
Pomegranate Extract (Urolithin A Precursor): Natural source, Lower cost, Additional polyphenols, Traditional use
Urolithin A + Precursor Complex: Combines direct and precursor, Better value, Comprehensive approach, Backup pathways
Food sources
Pomegranate
Precursor compounds, depends on gut bacteria conversion · 20
Berries, nuts
Trace precursors, minimal urolithin A production · 10
Urolithin A supplement
500-1000mg providing direct bioavailable urolithin A · 85
Too little
- Mitochondrial dysfunction symptoms:
- Chronic fatigue and low energy
- Poor exercise tolerance and endurance
- Slow recovery from physical stress
- Brain fog and cognitive fatigue
- Muscle weakness and poor performance
- Accelerated aging and cellular decline
Too much
- Urolithin A excess symptoms (theoretical):
- Digestive upset and nausea
- Unknown long-term effects
- Potential interaction with medications
- Headaches in sensitive individuals
- Limited safety data available
- Theoretical overstimulation of cellular processes
Who benefits most
aging-adults-energy-decline
Age-related mitochondrial decline and energy loss
500-1000mg daily for mitochondrial support
athletes-endurance-performance
Enhanced muscle energy metabolism and endurance
500-1000mg daily for performance support
chronic-fatigue-low-energy
Mitochondrial dysfunction often underlies fatigue
500-1000mg daily for energy enhancement
longevity-anti-aging-focused
Mitochondrial health central to healthy aging
500mg daily for longevity support
cognitive-enhancement-seekers
Brain energy metabolism and cognitive function
500mg daily for cognitive supportWhere to buy it
Look for Urolithin A for Mitochondrial Health and Cellular Energy at 500-1000mg daily per serving. The form that matters here is Synthetic Urolithin A.
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What else affects it
Beyond other supplements
!
Excessive oxidative stress
High oxidative stress may overwhelm mitochondrial benefits
Oxidative damage counteracts mitochondrial improvementsHow it works
- Activates mitophagy to remove damaged mitochondria
- Promotes mitochondrial biogenesis and renewal
- Enhances mitochondrial respiratory chain efficiency
- Improves cellular ATP production and energy metabolism
- Reduces mitochondrial oxidative stress and damage
- Supports healthy cellular aging and longevity
Key findings
what the evidence supports- First supplement shown to activate mitophagy in humans
- Improves mitochondrial function and muscle endurance
- Promising for healthy aging and longevity
- Generally safe with minimal side effects in clinical trials
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Urolithin A for Mitochondrial Health and Cellular Energy?
Documented effects: Enhanced mitochondrial health and function; Increased cellular energy and ATP production; Improved muscle endurance and recovery; Anti-aging and longevity support. Improves mitochondrial quality and energy production
How much Urolithin A for Mitochondrial Health and Cellular Energy should you take per day?
The common daily range is 500-1000mg daily. By goal — mitochondrial support: 500mg daily for basic mitochondrial enhancement; energy enhancement: 500-1000mg daily for improved cellular energy; athletic performance: 1000mg daily for endurance and recovery support; maximum research: Generally safe up to 1000mg daily based on studies.
When is the best time to take Urolithin A for Mitochondrial Health and Cellular Energy?
Empty stomach morning. First effects are typically reported within 2-4 weeks for energy and cellular improvements.
What are the side effects of Urolithin A for Mitochondrial Health and Cellular Energy?
At excessive doses: Urolithin A excess symptoms (theoretical):, Digestive upset and nausea, Unknown long-term effects, Potential interaction with medications, Headaches in sensitive individuals. Safety rating at normal doses is 7 out of 10.
What should you not take with Urolithin A for Mitochondrial Health and Cellular Energy?
Separate it from Excessive Oxidative Stress, Mitochondrial Toxins by two to four hours. High oxidative stress may overwhelm mitochondrial benefits
Does Urolithin A for Mitochondrial Health and Cellular Energy interact with medications?
Documented interactions with mitochondrial-targeting-drugs, blood-thinning-medications, diabetes-medications. Discuss these with a pharmacist before combining.
How do you know if you need Urolithin A for Mitochondrial Health and Cellular Energy?
The marker is Mitochondrial function markers, cellular energy metabolites, oxidative stress markers, optimal range Improved mitochondrial markers, enhanced cellular energy. Common deficiency signs: Mitochondrial dysfunction symptoms:, Chronic fatigue and low energy, Poor exercise tolerance and endurance, Slow recovery from physical stress.