Enhanced mental energy and alertness
Significantly improves mental energy and reduces fatigue
Sulbutiamine
Synthetic derivative of thiamine (vitamin B1) with enhanced brain bioavailability, supporting energy metabolism and cognitive function
Scientific nameSulbutiamine
FormulaC32H46N8O6S2
Molecular weight702.89 g/mol
CAS3286-46-2
90
absorption score
7
safety / 10
30
USD per month
5
documented interactions
Check it against something
Sulbutiamine with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimImproved mood and motivation
Enhances mood and increases motivation levels
Enhanced cognitive performance
Improves memory, focus, and mental clarity
Reduced mental fatigue
Decreases symptoms of mental exhaustion and burnout
Athletic performance enhancement
May improve physical endurance and reduce fatigue
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Ashwagandha
Stress management & energy
300-600mg
A
75%
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Vitamin B3 (Niacinamide)
Energy & skin health (no flush)
100-1000 mg
A
88%
Every pair we checked
12 combinations scored by the engine
Sulbutiamine + Caffeine
May increase overstimulation risk
Needs attention
61
Sulbutiamine + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Sulbutiamine + Calcium Carbonate
No documented interaction either way
No known interaction
70
Sulbutiamine + Whey Protein
No documented interaction either way
No known interaction
70
Sulbutiamine + Lactase
No documented interaction either way
No known interaction
70
Sulbutiamine + Bovine Collagen
No documented interaction either way
No known interaction
70
Sulbutiamine + DHA
No documented interaction either way
No known interaction
70
Sulbutiamine + Turmeric
No documented interaction either way
No known interaction
70
Sulbutiamine + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Sulbutiamine + Acetyl-L-Carnitine
Enhanced mitochondrial function and energy
Works better together
75
Sulbutiamine + Vitamin D3
Enhanced energy metabolism and cognitive function
Works better together
78
Sulbutiamine + Magnesium Oxide
Improved energy production and reduced side effects
Works better together
78
Dosage
Daily200-400mg
Mental energy200-600mg daily
Cognitive enhancement200-400mg daily
Mood support200-400mg daily
Chronic fatigue200-600mg daily
When to expect it
First Effects30-60 minutes for energy and mood benefits
Peak Benefits2-4 hours for optimal cognitive enhancement
Deficiency DevelopmentNot applicable - synthetic compound
Toxicity OnsetRare, mainly tolerance and overstimulation
How to measure it
MarkerThiamine levels, thiamine pyrophosphate
OptimalImproved thiamine status markers
Deficient belowNot applicable for synthetic compound
FrequencyOnly if monitoring thiamine status
What people actually reported to the FDA
CAERS, 0 reports naming it as the suspect
Named as the suspect
0 reports
of 1 that mention it at all
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 90 of 100 · best absorbed form of this compound
Delivered daily
270 mg
Cost per 100 mg delivered
$0.37 comparative — uses the absorption score, not a measured percentage
Works better with
+
B Complex Vitamins
Enhanced energy metabolism and cognitive function
B-vitamins work together in energy production pathways · level B
+
Magnesium
Improved energy production and reduced side effects
Magnesium supports ATP synthesis and nervous system function · level B
+
Acetyl L Carnitine
Enhanced mitochondrial function and energy
Both support cellular energy production · level CWhat not to take with Sulbutiamine
!
Alcohol
Alcohol depletes thiamine and may reduce effectiveness
Alcohol interferes with thiamine metabolism · moderate significance
!
Caffeine High Doses
May increase overstimulation risk
Additive stimulant effects · minor significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance stimulant effects
What to do: Monitor for overstimulation
May affect mood medication effectiveness
What to do: Monitor mood changes
May affect blood sugar control
What to do: Monitor blood glucose
Available forms
Sulbutiamine (synthetic thiamine derivative): Excellent brain penetration, Mental energy boost, Mood enhancement, Fast-acting
Food sources
Not found in natural foods
Synthetic compound only · N/A
Supplements only
200-400mg per capsule · 90
Prescription medications (some countries)
200mg tablets · 90
Regular thiamine (B1) less effective
Poor brain penetration · 20
Too little
- Not applicable (synthetic compound):
- Symptoms addressed by sulbutiamine:
- Mental fatigue and exhaustion
- Poor concentration and focus
- Low motivation and drive
- Mood issues and irritability
- Chronic fatigue syndrome symptoms
Too much
- Generally safe but potential effects:
- Tolerance development with regular use
- Insomnia and sleep disturbances
- Headaches and irritability
- Overstimulation and anxiety
- Mood swings
Who benefits most
mental-energy-fatigue
Excellent for combating mental fatigue and increasing alertness
200-600mg daily
cognitive-enhancement
Improves memory, focus, and mental performance
200-400mg daily
mood-motivation
Enhances mood and increases motivation levels
200-400mg daily
students-professionals
Popular for studying and demanding mental work
200-400mg as needed
chronic-fatigue
May help with chronic fatigue syndrome symptoms
200-600mg dailyWhere to buy it
Look for Sulbutiamine at 200-400mg per serving. The form that matters here is Sulbutiamine (synthetic thiamine derivative).
Find on Amazon
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What else affects it
Beyond other supplements
!
Alcohol
Alcohol depletes thiamine and may reduce effectiveness
Alcohol interferes with thiamine metabolismHow it works
- Increases brain thiamine levels much more than regular B1
- Enhances ATP production in brain cells
- Modulates dopamine and cholinergic neurotransmission
- Improves cellular energy metabolism
- Crosses blood-brain barrier efficiently due to lipophilic nature
- Supports mitochondrial function in neurons
Key findings
what the evidence supports- Good evidence for mental energy and cognitive enhancement
- Effective for reducing mental fatigue and improving mood
- Superior brain bioavailability compared to regular thiamine
- Tolerance development limits long-term daily use
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Sulbutiamine?
Documented effects: Enhanced mental energy and alertness; Improved mood and motivation; Enhanced cognitive performance; Reduced mental fatigue. Significantly improves mental energy and reduces fatigue
How much Sulbutiamine should you take per day?
The common daily range is 200-400mg. By goal — mental energy: 200-600mg daily; cognitive enhancement: 200-400mg daily; mood support: 200-400mg daily; chronic fatigue: 200-600mg daily.
When is the best time to take Sulbutiamine?
Morning with food. First effects are typically reported within 30-60 minutes for energy and mood benefits.
What are the side effects of Sulbutiamine?
At excessive doses: Generally safe but potential effects:, Tolerance development with regular use, Insomnia and sleep disturbances, Headaches and irritability, Overstimulation and anxiety. Safety rating at normal doses is 7 out of 10.
What should you not take with Sulbutiamine?
Separate it from Alcohol, Caffeine High Doses by two to four hours. Alcohol depletes thiamine and may reduce effectiveness
Does Sulbutiamine interact with medications?
Documented interactions with stimulant-medications, antidepressants, diabetes-medications. Discuss these with a pharmacist before combining.
How do you know if you need Sulbutiamine?
The marker is Thiamine levels, thiamine pyrophosphate, optimal range Improved thiamine status markers. Common deficiency signs: Not applicable (synthetic compound):, Symptoms addressed by sulbutiamine:, Mental fatigue and exhaustion, Poor concentration and focus.