Menopause symptom relief
Reduces hot flashes, night sweats, and mood swings
Progesterone Cream
Bioidentical progesterone hormone delivered through topical cream for women's hormonal balance and wellness
Scientific nameTopical progesterone USP
FormulaC21H30O2
Molecular weight314.46 g/mol
CAS57-83-0
90
absorption score
8
safety / 10
40
USD per month
5
documented interactions
Check it against something
Progesterone Cream with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimPMS and cycle regulation
Improves premenstrual symptoms and cycle regularity
Improved sleep quality
Promotes deeper, more restful sleep
Mood stabilization and anxiety relief
Supports emotional balance and reduces anxiety
Bone health support
Supports bone density and reduces fracture risk
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Melatonin
Sleep support & circadian rhythm
0.5-3mg
A
50%
Boron - Essential Trace Mineral for Bone and Hormone Health
Bone health & hormone support
3-10mg daily
B
85%
Iodine (Thyroid Support)
Thyroid hormone production
150-300mcg
A
95%
Iodine (Potassium Iodide)
Essential thyroid & metabolism support
150-300 mcg
A
95%
Fenugreek
Blood sugar control & testosterone support
500-1000mg
B
75%
T4 Levothyroxine - Primary Thyroid Hormone
Thyroid hormone replacement
PRESCRIPTION ONLY - 25-200mcg
A
80%
Every pair we checked
12 combinations scored by the engine
Progesterone Cream + Caffeine
No documented interaction either way
No known interaction
70
Progesterone Cream + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Progesterone Cream + Calcium Carbonate
No documented interaction either way
No known interaction
70
Progesterone Cream + Whey Protein
No documented interaction either way
No known interaction
70
Progesterone Cream + Lactase
No documented interaction either way
No known interaction
70
Progesterone Cream + Bovine Collagen
No documented interaction either way
No known interaction
70
Progesterone Cream + DHA
No documented interaction either way
No known interaction
70
Progesterone Cream + Turmeric
No documented interaction either way
No known interaction
70
Progesterone Cream + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Progesterone Cream + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced anti-inflammatory and mood benefits
Works better together
75
Progesterone Cream + Magnesium Oxide
Enhanced relaxation and sleep benefits
Works better together
78
Progesterone Cream + Vitamin D3
Improved mood and PMS symptom relief
Works better together
78
Dosage
Daily15-40mg topically
Pms cycle support15-25mg daily, luteal phase
Perimenopause support20-40mg daily, days 12-26
Post menopause15-30mg daily continuously
MaximumGenerally not more than 50mg daily without medical supervision
When to expect it
First Effects1-2 weeks for sleep and mood improvements
Peak Benefits2-3 months for optimal hormonal balance and symptom relief
Deficiency DevelopmentProgesterone deficiency common after age 35
Toxicity OnsetOverdose rare but may cause excessive drowsiness
How to measure it
MarkerProgesterone, estradiol, testosterone, cortisol, SHBG
OptimalProgesterone: 5-20 ng/mL luteal phase, 1-3 ng/mL post-menopause
Deficient belowProgesterone: <5 ng/mL luteal phase
FrequencyBaseline, then 8-12 weeks after starting, then every 6 months
What people actually reported to the FDA
CAERS, 1 reports naming it as the suspectMost reported effects
Named as the suspect
1 reports
of 1 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Hospitalization1
Other Serious or Important Medical Event1
Other Serious Outcome1
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 90 of 100 · best absorbed form of this compound
Delivered daily
24.8 mg
Cost per 100 mg delivered
$5.39 comparative — uses the absorption score, not a measured percentage
Works better with
+
Magnesium
Enhanced relaxation and sleep benefits
Both support GABA function and muscle relaxation · level B
+
Vitamin B6
Improved mood and PMS symptom relief
B6 supports progesterone production and neurotransmitter balance · level B
+
Omega 3 Fatty Acids
Enhanced anti-inflammatory and mood benefits
Support hormone synthesis and reduce inflammation · level CWhat not to take with Progesterone Cream
!
Xenoestrogens
Competes with progesterone effects
Environmental estrogens disrupt hormone balance · high significance
!
Excessive Stress
Depletes progesterone production
Cortisol production uses progesterone precursors · high significanceMedication interactions
Discuss these with a pharmacist before combiningMay have additive hormonal effects
What to do: Requires medical supervision and monitoring
May affect bleeding risk
What to do: Monitor clotting parameters
May enhance sedative effects
What to do: Monitor for increased drowsiness
Available forms
Bioidentical Progesterone Cream: Bioidentical, Bypasses liver, Natural balance, Well-researched
Food sources
Natural endogenous production only
Cannot be obtained from food sources · N/A
Wild yam (diosgenin precursor)
Contains precursor but not bioactive progesterone · 5
Bioidentical progesterone cream
Identical to endogenous hormone · 90
Too little
- Progesterone deficiency symptoms (common after 35):
- PMS symptoms and irregular cycles
- Hot flashes and night sweats
- Sleep disturbances and insomnia
- Anxiety and mood swings
- Weight gain, especially around midsection
- Breast tenderness and fibrocystic breasts
Too much
- Progesterone excess symptoms (rare):
- Excessive drowsiness and fatigue
- Depression or mood changes
- Breast tenderness
- Bloating and weight gain
- Skin changes or acne
- Headaches (rare)
Who benefits most
perimenopausal-menopausal-women
Natural progesterone decline during menopause transition
20-40mg daily, days 12-26 of cycle or daily if post-menopausal
pms-irregular-cycles
Support for premenstrual symptoms and cycle regulation
15-30mg daily, luteal phase (day 12-26)
sleep-anxiety-issues
Natural calming and sleep-promoting effects
15-25mg before bedtime
estrogen-dominance
Balances excess estrogen effects
20-40mg daily as needed for balance
bone-health-concern
Supports bone formation and density
20-30mg daily with calcium and vitamin DWhere to buy it
Look for Progesterone Cream at 15-40mg topically per serving. The form that matters here is Bioidentical Progesterone Cream.
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What else affects it
Beyond other supplements
!
Excessive stress
Depletes progesterone production
Cortisol production uses progesterone precursorsHow it works
- Binds to progesterone receptors throughout the body
- Modulates GABA-A receptors promoting relaxation and sleep
- Counteracts estrogen's proliferative effects on tissues
- Supports myelin sheath formation and neural protection
- Stimulates osteoblast activity for bone formation
- Modulates cortisol and stress hormone production
Key findings
what the evidence supports- Bioidentical progesterone effective for menopause symptom relief
- Topical application provides good bioavailability with fewer side effects
- Particularly effective for sleep, mood, and hot flash management
- Requires proper timing and dosing for optimal benefits
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Progesterone Cream?
Documented effects: Menopause symptom relief; PMS and cycle regulation; Improved sleep quality; Mood stabilization and anxiety relief. Reduces hot flashes, night sweats, and mood swings
How much Progesterone Cream should you take per day?
The common daily range is 15-40mg topically. By goal — pms cycle support: 15-25mg daily, luteal phase; perimenopause support: 20-40mg daily, days 12-26; post menopause: 15-30mg daily continuously; maximum: Generally not more than 50mg daily without medical supervision.
When is the best time to take Progesterone Cream?
Evening or luteal phase. First effects are typically reported within 1-2 weeks for sleep and mood improvements.
What are the side effects of Progesterone Cream?
At excessive doses: Progesterone excess symptoms (rare):, Excessive drowsiness and fatigue, Depression or mood changes, Breast tenderness, Bloating and weight gain. Safety rating at normal doses is 8 out of 10.
What should you not take with Progesterone Cream?
Separate it from Xenoestrogens, Excessive Stress by two to four hours. Competes with progesterone effects
Does Progesterone Cream interact with medications?
Documented interactions with hormone-replacement-therapy, blood-thinners, sedatives. Discuss these with a pharmacist before combining.
How do you know if you need Progesterone Cream?
The marker is Progesterone, estradiol, testosterone, cortisol, SHBG, optimal range Progesterone: 5-20 ng/mL luteal phase, 1-3 ng/mL post-menopause. Common deficiency signs: Progesterone deficiency symptoms (common after 35):, PMS symptoms and irregular cycles, Hot flashes and night sweats, Sleep disturbances and insomnia.