Pomegranate Extract

Potent antioxidant extract rich in punicalagins and ellagic acid, supporting cardiovascular health, prostate health, and cellular protection

Scientific namePunica granatum FormulaC48H28O30 (punicalagin) Molecular weight1084.71 g/mol CAS65995-63-3

80 absorption score

8 safety / 10

45 USD per month

5 documented interactions

Check it against something

Evidence level C

Pomegranate Extract with:

75 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Cardiovascular health and heart protection

Clinically proven support for heart health and arterial function

Antioxidants protect against atherosclerosis and improve endothelial function Evidence A-grade 6-12 weeks

Prostate health support

Supports healthy prostate function and PSA levels

Anti-inflammatory and antioxidant effects support prostate tissue health Evidence B-grade 8-16 weeks

Powerful antioxidant protection

Exceptional antioxidant activity protecting against cellular damage

Punicalagins and ellagic acid provide potent free radical neutralization Evidence A-grade 2-8 weeks

Anti-inflammatory support

Reduces systemic inflammation and inflammatory markers

Polyphenols inhibit inflammatory pathways and reduce inflammatory mediators Evidence A-grade 4-12 weeks

Memory and cognitive support

Supports brain health and cognitive function

Antioxidants protect brain tissue and support healthy circulation Evidence B-grade 8-16 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Turmeric Anti-inflammatory & antioxidant 300-1000mg A 3% Coenzyme Q10 (CoQ10) Heart health & cellular energy 100-200mg A 10% Fish Oil (EPA/DHA) Heart & brain health 1-2g EPA/DHA A 85% Glutathione Master antioxidant & detox support 250-750mg B 20% Psyllium Husk Digestive health & cholesterol support 5-15g A 95% Astaxanthin Superior antioxidant & skin protection 4-12mg B 20%

Every pair we checked

12 combinations scored by the engine

Pomegranate Extract + Iron Sulfate High iron may reduce antioxidant benefits Needs attention 58

Pomegranate Extract + Caffeine No documented interaction either way No known interaction 70

Pomegranate Extract + Creatine Monohydrate No documented interaction either way No known interaction 70

Pomegranate Extract + Calcium Carbonate No documented interaction either way No known interaction 70

Pomegranate Extract + Whey Protein No documented interaction either way No known interaction 70

Pomegranate Extract + Lactase No documented interaction either way No known interaction 70

Pomegranate Extract + Bovine Collagen No documented interaction either way No known interaction 70

Pomegranate Extract + DHA No documented interaction either way No known interaction 70

Pomegranate Extract + Turmeric No documented interaction either way No known interaction 70

Pomegranate Extract + Vitamin D3 Enhanced antioxidant protection and bioavailability Works better together 75

Pomegranate Extract + Coenzyme Q10 (CoQ10) Synergistic cardiovascular and cellular protection Works better together 75

Pomegranate Extract + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula Enhanced anti-inflammatory and cardiovascular support Works better together 78

Dosage

With meals

Daily500-1500mg

Cardiovascular health500-1000mg daily

Prostate support500-1000mg daily

Anti inflammatory500-1500mg daily

Cognitive support500-1000mg daily

Before you take it

VeganYes

When to expect it

First Effects2-6 weeks for antioxidant and anti-inflammatory benefits

Peak Benefits8-16 weeks for sustained cardiovascular and prostate support

Deficiency DevelopmentNot applicable - herbal supplement

Toxicity OnsetRare, mainly medication interactions

How to measure it

$100-200

MarkerBlood pressure, lipid profile, inflammatory markers (CRP), PSA if relevant

OptimalNormal blood pressure, improved lipid profile, reduced inflammation

Deficient belowNot applicable for herbal supplement

FrequencyEvery 3-6 months for cardiovascular and inflammatory monitoring

What people actually reported to the FDA

CAERS, 5 reports naming it as the suspect

Most reported effects

Cerebrovascular accident 2

Asthenia 1

Colon cancer 1

Lethargy 1

Blindness 1

Named as the suspect 5 reports of 5 that mention it at all

Serious outcome 77% hospitalisation, emergency room or worse

Other Serious or Important Medical Event4

Visited a Health Care Provider3

Hospitalization3

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption Very high 80 of 100 · best absorbed form of this compound

Delivered daily 800 mg

Cost per 100 mg delivered $0.19 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Vitamin C

Enhanced antioxidant protection and bioavailability

Vitamin C enhances absorption and regenerates pomegranate antioxidants · level C

Coq10

Synergistic cardiovascular and cellular protection

Complementary cardioprotective and antioxidant mechanisms · level C

Omega 3 Fatty Acids

Enhanced anti-inflammatory and cardiovascular support

Synergistic anti-inflammatory effects for heart health · level B

What not to take with Pomegranate Extract

2 documented

Iron Supplements High

High iron may reduce antioxidant benefits

Excess iron can promote oxidative stress · mild significance

Alcohol Excess

Excessive alcohol may reduce cardiovascular benefits

Alcohol can increase inflammation and oxidative stress · moderate significance

Medication interactions

Discuss these with a pharmacist before combining

ace-inhibitors Moderate

May enhance blood pressure lowering effects

What to do: Monitor blood pressure closely

blood-thinners Moderate

May enhance anticoagulant effects

What to do: Monitor bleeding parameters

rosuvastatin Minor

May increase statin levels

What to do: Monitor for statin side effects

Available forms

bioavailability compared

Pomegranate Extract (Standardized 40% Ellagic Acid) 80

Pomegranate Extract (Standardized 40% Ellagic Acid): Clinically proven heart benefits, Powerful antioxidant, Prostate support, Strong research

Food sources

before you supplement

Fresh pomegranate juice High polyphenol content · 75

Pomegranate arils (seeds) Moderate antioxidant content · 60

Standardized extracts Concentrated punicalagins and ellagic acid · 80

Pomegranate molasses Concentrated but high sugar · 50

Too little

deficiency signs

Not applicable (herbal supplement, not essential nutrient):
General symptoms addressed by pomegranate extract:
High cardiovascular disease risk
Chronic systemic inflammation
High oxidative stress and cellular damage
Prostate health concerns in men
Cognitive decline and poor brain health

Too much

toxicity signs

Generally safe with some considerations:
Low blood pressure with blood pressure medications
Enhanced effects of ACE inhibitors
Increased bleeding risk with blood thinners
Rare allergic reactions

Who benefits most

cardiovascular-health-heart-disease

Clinically proven cardiovascular protection and heart health support

500-1000mg daily (standardized extract)

prostate-health-men

Research-supported prostate health and PSA level support

500-1000mg daily

high-inflammation-chronic

Powerful anti-inflammatory support for chronic inflammatory conditions

500-1500mg daily

cognitive-health-memory

Brain health and cognitive function support through antioxidant protection

500-1000mg daily

anti-aging-cellular-protection

Exceptional antioxidant protection for healthy aging and cellular health

300-800mg daily

Where to buy it

compare forms first

Look for Pomegranate Extract at 500-1500mg per serving. The form that matters here is Pomegranate Extract (Standardized 40% Ellagic Acid).

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What else affects it

Beyond other supplements

Alcohol excess

Excessive alcohol may reduce cardiovascular benefits

Alcohol can increase inflammation and oxidative stress

How it works

Punicalagins and ellagic acid provide exceptional antioxidant protection against oxidative damage
Antioxidants protect against atherosclerosis and improve endothelial function
Anti-inflammatory polyphenols inhibit inflammatory pathways and reduce systemic inflammation
Supports healthy blood flow and circulation to organs and tissues
Protects prostate tissue through anti-inflammatory and antioxidant mechanisms
Neuroprotective effects support brain health and cognitive function

Key findings

what the evidence supports

Strong clinical evidence for cardiovascular health benefits
Proven antioxidant and anti-inflammatory effects
Promising research on prostate health and cognitive function
Important drug interactions requiring medical supervision

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Pomegranate Extract?

Documented effects: Cardiovascular health and heart protection; Prostate health support; Powerful antioxidant protection; Anti-inflammatory support. Clinically proven support for heart health and arterial function

How much Pomegranate Extract should you take per day?

The common daily range is 500-1500mg. By goal — cardiovascular health: 500-1000mg daily; prostate support: 500-1000mg daily; anti inflammatory: 500-1500mg daily; cognitive support: 500-1000mg daily.

When is the best time to take Pomegranate Extract?

With meals. First effects are typically reported within 2-6 weeks for antioxidant and anti-inflammatory benefits.

What are the side effects of Pomegranate Extract?

At excessive doses: Generally safe with some considerations:, Low blood pressure with blood pressure medications, Enhanced effects of ACE inhibitors, Increased bleeding risk with blood thinners, Rare allergic reactions. Safety rating at normal doses is 8 out of 10.

What should you not take with Pomegranate Extract?

Separate it from Iron Supplements High, Alcohol Excess by two to four hours. High iron may reduce antioxidant benefits

Does Pomegranate Extract interact with medications?

Documented interactions with ace-inhibitors, blood-thinners, rosuvastatin. Discuss these with a pharmacist before combining.

How do you know if you need Pomegranate Extract?

The marker is Blood pressure, lipid profile, inflammatory markers (CRP), PSA if relevant, optimal range Normal blood pressure, improved lipid profile, reduced inflammation. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by pomegranate extract:, High cardiovascular disease risk, Chronic systemic inflammation.

Taken for

52 Heart

Fish Oil (EPA/DHA) · EPA · Olive Oil Extract

49 Liver & Detox

Turmeric · Vitamin C (Ascorbic Acid) · D-Mannose