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Nettle Leaf

Nutrient-dense traditional herb supporting kidney function, urinary health, and providing natural diuretic and anti-inflammatory benefits

Scientific nameUrtica dioica FormulaVarious minerals, vitamins, and plant compounds Molecular weightVariable natural compounds g/mol CASVarious natural compounds
65 absorption score
9 safety / 10
22 USD per month
5 documented interactions

Check it against something

Evidence level C

Nettle Leaf with:

Compatibility score 80 out of 100
80 out of 100
Works better together Take together — same timing window amplifies the synergy.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Kidney function support

Supports healthy kidney function and filtration through nutritive and diuretic action

Rich mineral content and diuretic compounds support kidney health Evidence B-grade 1-4 weeks

Natural diuretic action

Gentle diuretic effects support healthy fluid balance and urine production

Natural compounds increase urine flow without depleting electrolytes Evidence B-grade 2-8 hours

Urinary tract health

Traditional support for overall urinary tract health and function

Anti-inflammatory and nutritive effects support urinary system health Evidence C-grade 1-3 weeks

Anti-inflammatory support

Provides natural anti-inflammatory benefits for kidneys and urinary tract

Anti-inflammatory compounds reduce tissue inflammation Evidence B-grade 1-6 weeks

Nutritional support and energy

Excellent source of vitamins, minerals, and nutrients supporting overall health

High content of iron, vitamins, and minerals supports energy and vitality Evidence A-grade 2-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Turmeric Anti-inflammatory & antioxidant 300-1000mg A 3% Glutathione Master antioxidant & detox support 250-750mg B 20% Astaxanthin Superior antioxidant & skin protection 4-12mg B 20% SAM-e Mood support & liver health 400-800mg A 70% Plant Collagen Vegan collagen support & antioxidants 2-5g C 70% Quercetin Immune support & allergy relief 500-1000mg B 5%

Every pair we checked

12 combinations scored by the engine
Nettle Leaf + Iron Sulfate Nettle's high iron content may add to iron load Needs attention 58
Nettle Leaf + Caffeine No documented interaction either way No known interaction 70
Nettle Leaf + Creatine Monohydrate No documented interaction either way No known interaction 70
Nettle Leaf + Calcium Carbonate No documented interaction either way No known interaction 70
Nettle Leaf + Whey Protein No documented interaction either way No known interaction 70
Nettle Leaf + Lactase No documented interaction either way No known interaction 70
Nettle Leaf + Bovine Collagen No documented interaction either way No known interaction 70
Nettle Leaf + DHA No documented interaction either way No known interaction 70
Nettle Leaf + Turmeric No documented interaction either way No known interaction 70
Nettle Leaf + Quercetin Enhanced anti-inflammatory and allergy support Works better together 75
Nettle Leaf + Vitamin D3 Enhanced iron absorption from nettle Works better together 78
Nettle Leaf + Dandelion Root Enhanced kidney support and diuretic effects Works better together 80

Dosage

With meals
Daily300-600mg
Kidney support300-600mg daily
Diuretic effect400-600mg daily
Nutritional support500-1000mg daily
Anti inflammatory400-800mg daily

Before you take it

VeganYes

When to expect it

First Effects2-8 hours for diuretic effects, 1-2 weeks for nutritional benefits
Peak Benefits4-8 weeks for sustained kidney support and nutritional improvements
Deficiency DevelopmentNot applicable - herbal supplement
Toxicity OnsetVery rare, excellent safety profile

How to measure it

$50-100
MarkerComplete blood count (iron status), kidney function if desired
OptimalImproved iron status, normal kidney function
Deficient belowNot applicable for herbal supplement
FrequencyEvery 6-12 months for nutritional monitoring

What people actually reported to the FDA

CAERS, 1 reports naming it as the suspect

Most reported effects

Arthralgia 1
Chills 1
Emergency care 1
Hypersensitivity 1
Pyrexia 1
Named as the suspect 1 reports of 1 that mention it at all
Serious outcome 67% hospitalisation, emergency room or worse
Other Serious or Important Medical Event1
Visited Emergency Room1
Allergic Reaction1

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not
Absorption High 65 of 100 · absorbs well relative to other forms
Delivered daily 292.5 mg
Cost per 100 mg delivered $0.25 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented
+
Dandelion Root

Enhanced kidney support and diuretic effects

Both provide complementary kidney-supportive and diuretic properties · level C
+
Vitamin C

Enhanced iron absorption from nettle

Vitamin C improves absorption of plant-based iron from nettle · level B
+
Quercetin

Enhanced anti-inflammatory and allergy support

Both provide anti-inflammatory and antihistamine effects · level C

What not to take with Nettle Leaf

2 documented
!
Pharmaceutical Diuretics

May enhance diuretic effects

Additive diuretic effects · mild significance
!
Iron Supplements Excess

Nettle's high iron content may add to iron load

Both provide iron supplementation · mild significance

Medication interactions

Discuss these with a pharmacist before combining
diabetes-medications Minor

May affect blood sugar levels

What to do: Monitor blood glucose levels

blood-pressure-medications Minor

May affect blood pressure due to diuretic action

What to do: Monitor blood pressure

blood-thinners Minor

High vitamin K content may affect anticoagulation

What to do: Monitor INR if on warfarin

Available forms

bioavailability compared
Nettle Leaf Extract (Standardized) 65

Nettle Leaf Extract (Standardized): Excellent safety, Rich in nutrients, Natural diuretic, Anti-inflammatory

Food sources

before you supplement
Fresh nettle leaves (cooked) High nutrient and active compound content · 70
Nettle tea Moderate active compound content · 55
Dried nettle powder Concentrated nutrients and compounds · 60
Standardized extracts Concentrated active compounds · 65

Too little

deficiency signs
  • Not applicable (herbal supplement, not essential nutrient):
  • General symptoms addressed by nettle leaf:
  • Poor kidney function and sluggish elimination
  • Mild fluid retention and bloating
  • Low energy and nutritional deficiencies
  • Chronic inflammation and poor recovery
  • General urinary tract sluggishness

Too much

toxicity signs
  • Extremely safe with minimal side effects:
  • Mild blood sugar effects
  • Mild blood pressure changes
  • Rare allergic reactions
  • Stomach upset if taken on empty stomach

Who benefits most

kidney-function-support

Traditional kidney tonic supporting healthy kidney function and filtration

300-600mg daily
fluid-retention-mild

Gentle natural diuretic for mild fluid retention and bloating

400-600mg daily
urinary-tract-health-general

Comprehensive support for urinary tract health and function

300-500mg daily
nutritional-support-energy

Excellent nutritional supplement for energy, iron, and mineral support

500-1000mg daily
anti-inflammatory-natural

Natural anti-inflammatory support for various conditions

400-800mg daily

Where to buy it

compare forms first

Look for Nettle Leaf at 300-600mg per serving. The form that matters here is Nettle Leaf Extract (Standardized).

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How it works

  • Natural diuretic compounds increase urine production supporting kidney function
  • Rich mineral content provides nutritional support for kidney health
  • Anti-inflammatory compounds reduce tissue inflammation in urinary tract
  • High potassium content helps maintain electrolyte balance during diuresis
  • Flavonoids and phenolic compounds provide antioxidant protection
  • Nutritive action supports overall kidney and urinary system health

Key findings

what the evidence supports
  • Strong traditional use evidence for kidney and urinary support
  • Excellent safety profile with minimal side effects
  • Good nutritional profile with high mineral and vitamin content
  • Promising anti-inflammatory effects in preliminary studies

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Nettle Leaf?

Documented effects: Kidney function support; Natural diuretic action; Urinary tract health; Anti-inflammatory support. Supports healthy kidney function and filtration through nutritive and diuretic action

How much Nettle Leaf should you take per day?

The common daily range is 300-600mg. By goal — kidney support: 300-600mg daily; diuretic effect: 400-600mg daily; nutritional support: 500-1000mg daily; anti inflammatory: 400-800mg daily.

When is the best time to take Nettle Leaf?

With meals. First effects are typically reported within 2-8 hours for diuretic effects, 1-2 weeks for nutritional benefits.

What are the side effects of Nettle Leaf?

At excessive doses: Extremely safe with minimal side effects:, Mild blood sugar effects, Mild blood pressure changes, Rare allergic reactions, Stomach upset if taken on empty stomach. Safety rating at normal doses is 9 out of 10.

What should you not take with Nettle Leaf?

Separate it from Pharmaceutical Diuretics, Iron Supplements Excess by two to four hours. May enhance diuretic effects

Does Nettle Leaf interact with medications?

Documented interactions with diabetes-medications, blood-pressure-medications, blood-thinners. Discuss these with a pharmacist before combining.

How do you know if you need Nettle Leaf?

The marker is Complete blood count (iron status), kidney function if desired, optimal range Improved iron status, normal kidney function. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by nettle leaf:, Poor kidney function and sluggish elimination, Mild fluid retention and bloating.

Taken for

49 Liver & Detox

Turmeric · Vitamin C (Ascorbic Acid) · D-Mannose