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Artichoke Extract

Standardized artichoke leaf extract rich in cynarin, supporting liver function, bile production, and cholesterol metabolism

Scientific nameCynara scolymus FormulaC25H24O12 (cynarin) Molecular weight516.45 g/mol CAS1182-34-9
75 absorption score
8 safety / 10
35 USD per month
5 documented interactions

Check it against something

Evidence level C

Artichoke Extract with:

Compatibility score 75 out of 100
75 out of 100
Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Liver function and protection

Clinically proven support for liver function and hepatic cell protection

Cynarin and chlorogenic acid provide hepatoprotective effects Evidence B-grade 4-8 weeks

Bile production and flow

Significantly increases bile production and improves bile flow

Cynarin acts as potent cholagogue and choleretic agent Evidence A-grade 30 minutes to 4 hours

Cholesterol metabolism support

Helps support healthy cholesterol levels and lipid metabolism

Enhanced bile production increases cholesterol elimination Evidence B-grade 6-12 weeks

Digestive support and fat digestion

Improves digestion, especially of fats, through enhanced bile flow

Increased bile production improves fat emulsification and absorption Evidence B-grade 30 minutes to 4 hours

Antioxidant liver protection

Provides powerful antioxidant protection for liver cells

Phenolic compounds protect hepatocytes from oxidative damage Evidence B-grade 2-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Turmeric Anti-inflammatory & antioxidant 300-1000mg A 3% Glutathione Master antioxidant & detox support 250-750mg B 20% Astaxanthin Superior antioxidant & skin protection 4-12mg B 20% SAM-e Mood support & liver health 400-800mg A 70% Plant Collagen Vegan collagen support & antioxidants 2-5g C 70% Quercetin Immune support & allergy relief 500-1000mg B 5%

Every pair we checked

12 combinations scored by the engine
Artichoke Extract + Caffeine No documented interaction either way No known interaction 70
Artichoke Extract + Creatine Monohydrate No documented interaction either way No known interaction 70
Artichoke Extract + Vitamin D3 No documented interaction either way No known interaction 70
Artichoke Extract + Calcium Carbonate No documented interaction either way No known interaction 70
Artichoke Extract + Whey Protein No documented interaction either way No known interaction 70
Artichoke Extract + Lactase No documented interaction either way No known interaction 70
Artichoke Extract + Bovine Collagen No documented interaction either way No known interaction 70
Artichoke Extract + DHA No documented interaction either way No known interaction 70
Artichoke Extract + Turmeric No documented interaction either way No known interaction 70
Artichoke Extract + Milk Thistle Enhanced liver protection and regeneration support Works better together 75
Artichoke Extract + Dandelion Root Synergistic bile production and liver support Works better together 75
Artichoke Extract + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula Enhanced liver protection and anti-inflammatory support Works better together 75

Dosage

Before meals
Daily300-600mg
Liver protection300-600mg daily
Bile stimulation300mg before fatty meals
Cholesterol support400-600mg daily
Digestive support300mg daily

Before you take it

VeganYes

When to expect it

First Effects30 minutes to 4 hours for bile stimulation and digestive benefits
Peak Benefits6-12 weeks for sustained liver support and cholesterol benefits
Deficiency DevelopmentNot applicable - herbal supplement
Toxicity OnsetRare, mainly gallstone complications or allergies

How to measure it

$80-150
MarkerLiver enzymes (ALT, AST, GGT), cholesterol panel, bilirubin
OptimalNormal liver function, improved cholesterol levels
Deficient belowNot applicable for herbal supplement
FrequencyEvery 3-6 months for liver and cholesterol monitoring

What people actually reported to the FDA

CAERS, 0 reports naming it as the suspect
Named as the suspect 0 reports of 1 that mention it at all

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not
Absorption High 75 of 100 · absorbs well relative to other forms
Delivered daily 337.5 mg
Cost per 100 mg delivered $0.35 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented
+
Milk Thistle

Enhanced liver protection and regeneration support

Both provide complementary hepatoprotective effects · level C
+
Dandelion Root

Synergistic bile production and liver support

Both stimulate bile production and hepatic function · level C
+
Turmeric Curcumin

Enhanced liver protection and anti-inflammatory support

Complementary liver-protective and anti-inflammatory effects · level C

What not to take with Artichoke Extract

2 documented
!
Alcohol Regular

Regular alcohol use opposes liver-protective effects

Alcohol creates liver stress opposing artichoke's protective effects · high significance
!
Hepatotoxic Medications

Liver-damaging drugs oppose liver-protective benefits

Direct opposition of liver protection mechanisms · moderate significance

Medication interactions

Discuss these with a pharmacist before combining
cholesterol-medications Minor

May enhance cholesterol-lowering effects

What to do: Monitor cholesterol levels

diabetes-medications Minor

May affect blood sugar levels

What to do: Monitor blood glucose levels

liver-metabolized-drugs Minor

May affect metabolism of liver-processed medications

What to do: Monitor drug levels if concerned

Available forms

bioavailability compared
Artichoke Leaf Extract (Standardized 5% Cynarin) 75

Artichoke Leaf Extract (Standardized 5% Cynarin): Proven liver protection, Strong bile stimulant, Good research, Cholesterol support

Food sources

before you supplement
Fresh artichoke hearts Lower concentration than extract · 40
Artichoke leaves (not commonly eaten) Highest cynarin content · 45
Standardized leaf extracts Concentrated cynarin (5-15%) · 75
Artichoke tea Moderate active compound content · 50

Too little

deficiency signs
  • Not applicable (herbal supplement, not essential nutrient):
  • General symptoms addressed by artichoke extract:
  • Poor fat digestion and gallbladder sluggishness
  • Elevated cholesterol levels
  • Liver congestion and poor detoxification
  • Digestive problems after fatty meals
  • General liver sluggishness and poor bile flow

Too much

toxicity signs
  • Generally safe with minimal side effects:
  • Gallbladder pain if gallstones present
  • Allergic reactions in sensitive individuals
  • Mild digestive upset
  • Rare skin reactions

Who benefits most

liver-function-support

Clinically proven liver protector and function supporter

300-600mg daily (standardized to 5% cynarin)
poor-fat-digestion

Excellent bile stimulant for improving fat digestion and gallbladder function

300mg before fatty meals
cholesterol-metabolism-support

Supports healthy cholesterol levels through enhanced bile production

400-600mg daily
liver-detoxification

Supports liver detoxification and hepatic cleansing processes

300-600mg daily
digestive-health-general

Comprehensive digestive support through liver and bile function

300mg daily

Where to buy it

compare forms first

Look for Artichoke Extract at 300-600mg per serving. The form that matters here is Artichoke Leaf Extract (Standardized 5% Cynarin).

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What else affects it

Beyond other supplements
!
Alcohol regular

Regular alcohol use opposes liver-protective effects

Alcohol creates liver stress opposing artichoke's protective effects

How it works

  • Cynarin acts as potent cholagogue increasing bile synthesis and secretion
  • Choleretic effects improve bile flow and prevent gallbladder stasis
  • Hepatoprotective compounds protect liver cells from oxidative damage
  • Enhanced bile production increases cholesterol elimination
  • Antioxidant phenolic compounds provide liver cell protection
  • Supports phase I and phase II liver detoxification pathways

Key findings

what the evidence supports
  • Clinically proven to increase bile production by up to 127%
  • Significant liver-protective effects in multiple studies
  • Modest but consistent cholesterol-lowering effects
  • Good safety profile when gallstones are not present

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Artichoke Extract?

Documented effects: Liver function and protection; Bile production and flow; Cholesterol metabolism support; Digestive support and fat digestion. Clinically proven support for liver function and hepatic cell protection

How much Artichoke Extract should you take per day?

The common daily range is 300-600mg. By goal — liver protection: 300-600mg daily; bile stimulation: 300mg before fatty meals; cholesterol support: 400-600mg daily; digestive support: 300mg daily.

When is the best time to take Artichoke Extract?

Before meals. First effects are typically reported within 30 minutes to 4 hours for bile stimulation and digestive benefits.

What are the side effects of Artichoke Extract?

At excessive doses: Generally safe with minimal side effects:, Gallbladder pain if gallstones present, Allergic reactions in sensitive individuals, Mild digestive upset, Rare skin reactions. Safety rating at normal doses is 8 out of 10.

What should you not take with Artichoke Extract?

Separate it from Alcohol Regular, Hepatotoxic Medications by two to four hours. Regular alcohol use opposes liver-protective effects

Does Artichoke Extract interact with medications?

Documented interactions with cholesterol-medications, diabetes-medications, liver-metabolized-drugs. Discuss these with a pharmacist before combining.

How do you know if you need Artichoke Extract?

The marker is Liver enzymes (ALT, AST, GGT), cholesterol panel, bilirubin, optimal range Normal liver function, improved cholesterol levels. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by artichoke extract:, Poor fat digestion and gallbladder sluggishness, Elevated cholesterol levels.

Taken for

49 Liver & Detox

Turmeric · Vitamin C (Ascorbic Acid) · D-Mannose