Vitex (Chasteberry)

Traditional women's herb supporting hormonal balance, menstrual regularity, and reproductive health through natural hormone regulation

Scientific nameVitex agnus-castus FormulaVarious diterpenes and flavonoids Molecular weightVariable natural compounds g/mol CASVarious natural compounds

70 absorption score

8 safety / 10

25 USD per month

5 documented interactions

Check it against something

Evidence level C

Vitex (Chasteberry) with:

75 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

PMS and menstrual cycle regulation

Reduces PMS symptoms and helps regulate irregular menstrual cycles

Modulates prolactin levels and supports luteal phase function Evidence A-grade 2-4 cycles (8-16 weeks)

Hormonal acne improvement

Reduces hormonal acne by balancing androgens and progesterone

Reduces excessive androgens and supports progesterone production Evidence B-grade 3-6 months

Fertility and ovulation support

Supports healthy ovulation and fertility in women

Normalizes luteinizing hormone and supports corpus luteum function Evidence B-grade 3-6 months

PCOS symptom management

Helps manage PCOS symptoms including irregular cycles and acne

Reduces prolactin and supports healthy androgen balance Evidence B-grade 3-6 months

Menopausal symptom relief

Provides relief from mild menopausal symptoms

Supports natural hormone production and balance during transition Evidence C-grade 2-4 months

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Melatonin Sleep support & circadian rhythm 0.5-3mg A 50% Boron - Essential Trace Mineral for Bone and Hormone Health Bone health & hormone support 3-10mg daily B 85% Iodine (Thyroid Support) Thyroid hormone production 150-300mcg A 95% Iodine (Potassium Iodide) Essential thyroid & metabolism support 150-300 mcg A 95% Fenugreek Blood sugar control & testosterone support 500-1000mg B 75% T4 Levothyroxine - Primary Thyroid Hormone Thyroid hormone replacement PRESCRIPTION ONLY - 25-200mcg A 80%

Every pair we checked

12 combinations scored by the engine

Vitex (Chasteberry) + Caffeine No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Creatine Monohydrate No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Calcium Carbonate No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Whey Protein No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Lactase No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Bovine Collagen No documented interaction either way No known interaction 70

Vitex (Chasteberry) + DHA No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Turmeric No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70

Vitex (Chasteberry) + Evening Primrose Oil Enhanced hormonal balance and PMS relief Works better together 75

Vitex (Chasteberry) + Magnesium Oxide Improved PMS symptoms and muscle relaxation Works better together 78

Vitex (Chasteberry) + Vitamin D3 Enhanced hormone metabolism and PMS relief Works better together 78

Dosage

Morning fasting

Daily20-40mg extract

Pms cycle regulation20-40mg extract daily

Hormonal acne20-40mg extract daily

Fertility support20-40mg extract daily

Pcos management20-40mg extract daily

Before you take it

VeganYes

When to expect it

First Effects4-8 weeks for initial PMS and cycle improvements

Peak Benefits3-6 months for sustained hormonal balance and cycle regulation

Deficiency DevelopmentNot applicable - herbal supplement

Toxicity OnsetRare, mainly contraindications

How to measure it

$150-300

MarkerProlactin, LH, FSH, progesterone, testosterone

OptimalNormal prolactin, improved luteal phase progesterone

Deficient belowNot applicable for herbal supplement

FrequencyEvery 3-6 months for hormone monitoring

What people actually reported to the FDA

CAERS, 12 reports naming it as the suspect

Most reported effects

Blood pressure increased 3

Abdominal pain 2

Anxiety 2

Suicidal ideation 2

Dyspnoea 2

Named as the suspect 12 reports of 14 that mention it at all

Serious outcome 75% hospitalisation, emergency room or worse

Other Serious or Important Medical Event8

Visited a Health Care Provider5

Visited Emergency Room4

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption High 70 of 100 · absorbs well relative to other forms

Delivered daily 21 mg

Cost per 100 mg delivered $3.97 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Evening Primrose Oil

Enhanced hormonal balance and PMS relief

Both support healthy hormone production and balance · level C

Magnesium

Improved PMS symptoms and muscle relaxation

Magnesium supports muscle function and hormone metabolism · level B

Vitamin B6

Enhanced hormone metabolism and PMS relief

B6 is essential for neurotransmitter and hormone metabolism · level B

What not to take with Vitex (Chasteberry)

2 documented

Hormone Replacement Therapy

May interfere with HRT effects

Both affect hormone levels and may have opposing effects · high significance

Birth Control Pills

May reduce effectiveness of hormonal contraceptives

May interfere with synthetic hormone regulation · moderate significance

Medication interactions

Discuss these with a pharmacist before combining

dopamine-medications Moderate

May enhance or interfere with dopamine drugs

What to do: Avoid concurrent use

hormone-replacement-therapy Moderate

May interfere with hormone therapy

What to do: Consult healthcare provider

birth-control-pills Moderate

May reduce contraceptive effectiveness

What to do: Use additional contraception

Available forms

bioavailability compared

Vitex Agnus-Castus Extract (Standardized) 70

Vitex Agnus-Castus Extract (Standardized): Clinically proven PMS benefits, Hormone regulation, Cycle support, Good research

Food sources

before you supplement

Chasteberry fruit (fresh) Natural active compounds · 60

Dried chasteberry Concentrated compounds · 65

Standardized extracts Concentrated active compounds · 70

Not found in common foods Specific herb preparation required · N/A

Too little

deficiency signs

Not applicable (herbal supplement, not essential nutrient):
General symptoms addressed by vitex:
Irregular menstrual cycles and heavy bleeding
Severe PMS symptoms including mood swings
Hormonal acne and skin problems
Difficulty conceiving due to luteal phase defects
PCOS-related symptoms and cycle irregularities

Too much

toxicity signs

Generally safe with some considerations:
Mild digestive upset or nausea
Headaches (rare)
Skin rash (rare)
Contraindicated in pregnancy and hormone-sensitive conditions

Who benefits most

pms-menstrual-irregularities

Clinically proven PMS relief and menstrual cycle regulation

20-40mg extract daily (or 175-225mg dried herb)

hormonal-acne-women

Effective hormonal acne treatment through androgen balance

20-40mg extract daily

fertility-ovulation-support

Natural fertility support through improved ovulation and luteal function

20-40mg extract daily

pcos-symptom-management

PCOS symptom relief including cycle regulation and acne reduction

20-40mg extract daily

perimenopause-symptoms

Mild menopausal symptom relief during hormonal transition

20-30mg extract daily

Where to buy it

compare forms first

Look for Vitex (Chasteberry) at 20-40mg extract per serving. The form that matters here is Vitex Agnus-Castus Extract (Standardized).

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How it works

Binds to dopamine D2 receptors in pituitary, reducing prolactin secretion
Supports luteal phase function by enhancing corpus luteum progesterone production
Modulates luteinizing hormone (LH) release for improved ovulation
Reduces excessive androgen production helping balance male/female hormones
Supports healthy follicle-stimulating hormone (FSH) levels
Provides mild estrogenic effects during perimenopause when estrogen declines

Key findings

what the evidence supports

Strong clinical evidence for PMS relief and cycle regulation
Proven benefits for hormonal acne in women
Good research on fertility support and luteal phase defects
Important contraindications for pregnancy and hormone-sensitive conditions

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Vitex (Chasteberry)?

Documented effects: PMS and menstrual cycle regulation; Hormonal acne improvement; Fertility and ovulation support; PCOS symptom management. Reduces PMS symptoms and helps regulate irregular menstrual cycles

How much Vitex (Chasteberry) should you take per day?

The common daily range is 20-40mg extract. By goal — pms cycle regulation: 20-40mg extract daily; hormonal acne: 20-40mg extract daily; fertility support: 20-40mg extract daily; pcos management: 20-40mg extract daily.

When is the best time to take Vitex (Chasteberry)?

Morning fasting. First effects are typically reported within 4-8 weeks for initial PMS and cycle improvements.

What are the side effects of Vitex (Chasteberry)?

At excessive doses: Generally safe with some considerations:, Mild digestive upset or nausea, Headaches (rare), Skin rash (rare), Contraindicated in pregnancy and hormone-sensitive conditions. Safety rating at normal doses is 8 out of 10.

What should you not take with Vitex (Chasteberry)?

Separate it from Hormone Replacement Therapy, Birth Control Pills by two to four hours. May interfere with HRT effects

Does Vitex (Chasteberry) interact with medications?

Documented interactions with dopamine-medications, hormone-replacement-therapy, birth-control-pills. Discuss these with a pharmacist before combining.

How do you know if you need Vitex (Chasteberry)?

The marker is Prolactin, LH, FSH, progesterone, testosterone, optimal range Normal prolactin, improved luteal phase progesterone. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by vitex:, Irregular menstrual cycles and heavy bleeding, Severe PMS symptoms including mood swings.

Taken for

27 Hormones

Melatonin · Vitamin B6 (Pyridoxine HCl) · Vitamin B6 (P5P)