Bone health optimization
Activates osteocalcin for proper bone mineralization
Vitamin K2 (MK-7)
Essential vitamin for proper calcium utilization, bone health, and cardiovascular protection
Scientific nameMenaquinone-7
FormulaC46H64O2
Molecular weight648.99 g/mol
CAS2124-57-4
80
absorption score
9
safety / 10
25
USD per month
5
documented interactions
Check it against something
Vitamin K2 (MK-7) with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
66
out of 100
Needs attention
Separate by 2-4 hours to avoid the interaction below.
What it does
mechanism and evidence for each claimCardiovascular protection
Prevents arterial calcification and stiffening
Improved calcium utilization
Ensures calcium goes to bones, not soft tissues
Dental health
Supports tooth mineralization and gum health
Reduced fracture risk
May reduce hip fracture risk by up to 77%
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Calcium
Bone health & muscle function
1,000-1,200 mg
A
30%
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Vitamin D3
Bone health & immune support
1000-2000 IU
A
85%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Every pair we checked
12 combinations scored by the engine
Vitamin K2 (MK-7) + Vitamin D3
High doses may interfere with K2 function
Needs attention
66
Vitamin K2 (MK-7) + Vitamin C (Ascorbic Acid)
High doses may interfere with K2 function
Needs attention
70
Vitamin K2 (MK-7) + Vitamin B12 (Methylcobalamin)
High doses may interfere with K2 function
Needs attention
70
Vitamin K2 (MK-7) + Caffeine
No documented interaction either way
No known interaction
70
Vitamin K2 (MK-7) + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Vitamin K2 (MK-7) + Whey Protein
No documented interaction either way
No known interaction
70
Vitamin K2 (MK-7) + Turmeric
No documented interaction either way
No known interaction
70
Vitamin K2 (MK-7) + Lactase
Improved calcium absorption when consuming dairy
Works better together
82
Vitamin K2 (MK-7) + Bovine Collagen
Essential for collagen synthesis and cross-linking
Works better together
82
Vitamin K2 (MK-7) + DHA
Prevents oxidation of DHA and enhances stability
Works better together
82
Vitamin K2 (MK-7) + Magnesium Oxide
Required for vitamin K-dependent protein function
Works better together
90
Vitamin K2 (MK-7) + Calcium Carbonate
K2 optimizes calcium utilization and placement
Works better together
99
Dosage
Daily100-200 mcg
Maintenance100-180 mcg
Therapeutic180-360 mcg
Maximum1000 mcg
ToxicNo established toxicity level
Before you take it
VeganYes
When to expect it
First Effects4-8 weeks for protein activation
Peak Benefits12-24 weeks for bone and cardiovascular benefits
Deficiency DevelopmentWeeks to months with inadequate intake
Toxicity OnsetNo known toxicity at supplemental doses
How to measure it
MarkerUndercarboxylated osteocalcin (ucOC)
Optimal<20% of total osteocalcin
FrequencyBaseline and 3-6 months after starting supplementation
What people actually reported to the FDA
CAERS, 33 reports naming it as the suspectMost reported effects
Named as the suspect
33 reports
of 92 that mention it at all
Serious outcome
85%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event21
Hospitalization17
Visited Emergency Room8
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 80 of 100 · best absorbed form of this compound
Delivered daily
0.1 mg
Cost per 1 mg delivered
$6.94 comparative — uses the absorption score, not a measured percentage
Works better with
+
Vitamin D3
D3 increases calcium absorption, K2 directs it to bones
Complementary calcium metabolism pathways · level A
+
Magnesium
Required for vitamin K-dependent protein function
Cofactor for gamma-carboxylase enzyme · level B
+
Calcium
K2 optimizes calcium utilization and placement
Activates proteins that bind and direct calcium · level AWhat not to take with Vitamin K2 (MK-7)
!
Vitamin A Excess
High doses may interfere with K2 function
Competition for similar metabolic pathways · mild significance
!
Vitamin E Excess
Very high doses may reduce K absorption
Competition for fat-soluble vitamin absorption · mild significanceMedication interactions
Discuss these with a pharmacist before combiningMay reduce anticoagulant effectiveness
What to do: Consult physician, may need dose adjustment
May reduce vitamin K2 production by gut bacteria
What to do: Consider K2 supplementation during antibiotic use
Available forms
Ranks 2 of 4 among vitamin k forms. Vitamin K2 (MK-9) absorbs better — 85%. Compare all forms →
MK-7 (Menaquinone-7): Longest half-life, Best studied, Most bioactive
MK-4 (Menaquinone-4): Less expensive, Some research support, Shorter half-life
All-trans MK-7: Highest bioactivity, Most stable form, Better absorption
Food sources
Natto (fermented soybeans)
1103 mcg/100g · 85
Goose liver
369 mcg/100g · 80
Hard cheeses
50-76 mcg/100g · 75
Egg yolks (pasture-raised)
32 mcg/100g · 70
Too little
- Easy bruising and bleeding
- Poor bone mineralization
- Increased arterial calcification
- Dental problems
- Increased fracture risk
- Subclinical vitamin K deficiency is common
- May manifest as cardiovascular disease
Too much
- No known toxicity from natural forms
- Potential interaction with blood thinners
- Mild digestive upset at very high doses
- Theoretical hemolysis (not observed)
- No upper limit established by authorities
Who benefits most
postmenopausal-women
Increased bone loss and cardiovascular risk
100-200 mcg daily
elderly-men
Increased arterial calcification and bone loss
100-200 mcg daily
vitamin-d-users
Vitamin D increases calcium absorption, K2 directs it properly
100-180 mcg daily
osteoporosis-risk
Essential for bone matrix formation
180-200 mcg daily
heart-disease-risk
May prevent arterial calcification
100-200 mcg dailyWhere to buy it
Look for Vitamin K2 (MK-7) at 100-200 mcg per serving. The form that matters here is MK-7 (Menaquinone-7).
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How it works
- Gamma-carboxylation of vitamin K-dependent proteins
- Activation of osteocalcin for bone mineralization
- Activation of matrix Gla protein (MGP) for vascular health
- Regulation of calcium deposition in tissues
- Supports proper blood clotting factor function
- Modulates inflammatory pathways
Key findings
what the evidence supports- Reduces hip fracture risk by 77% (meta-analysis 2013)
- Improves arterial elasticity in postmenopausal women (2015)
- Activates osteocalcin more effectively than K1 (2007)
- May reverse coronary artery calcification (2009 study)
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Vitamin K2 (MK-7)?
Documented effects: Bone health optimization; Cardiovascular protection; Improved calcium utilization; Dental health. Activates osteocalcin for proper bone mineralization
How much Vitamin K2 (MK-7) should you take per day?
The common daily range is 100-200 mcg. By goal — maintenance: 100-180 mcg; therapeutic: 180-360 mcg; maximum: 1000 mcg; toxic: No established toxicity level.
When is the best time to take Vitamin K2 (MK-7)?
With fat meal. First effects are typically reported within 4-8 weeks for protein activation.
What are the side effects of Vitamin K2 (MK-7)?
At excessive doses: No known toxicity from natural forms, Potential interaction with blood thinners, Mild digestive upset at very high doses, Theoretical hemolysis (not observed), No upper limit established by authorities. Safety rating at normal doses is 9 out of 10.
What should you not take with Vitamin K2 (MK-7)?
Separate it from Vitamin A Excess, Vitamin E Excess by two to four hours. High doses may interfere with K2 function
Does Vitamin K2 (MK-7) interact with medications?
Documented interactions with warfarin-coumadin, antibiotics-broad-spectrum. Discuss these with a pharmacist before combining.
How do you know if you need Vitamin K2 (MK-7)?
The marker is Undercarboxylated osteocalcin (ucOC), optimal range <20% of total osteocalcin. Common deficiency signs: Easy bruising and bleeding, Poor bone mineralization, Increased arterial calcification, Dental problems.