Vitamin E (Gamma-Tocopherol)

Alternative form of vitamin E with unique anti-inflammatory properties and nitrogen radical scavenging ability

Scientific nameγ-Tocopherol FormulaC28H48O2 Molecular weight416.68 g/mol CAS54-28-4

85 absorption score

8 safety / 10

35 USD per month

5 documented interactions

Check it against something

Evidence level A

Vitamin E (Gamma-Tocopherol) with:

94 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Superior anti-inflammatory effects

More effective than alpha-tocopherol at reducing inflammation

Unique ability to scavenge nitrogen radicals and reduce inflammatory mediators Evidence B-grade 4-8 weeks

Enhanced cardiovascular protection

Better heart health benefits than alpha-tocopherol alone

Reduces LDL oxidation and inflammatory markers Evidence B-grade 8-12 weeks

Prostate health support

May reduce prostate cancer risk better than alpha-tocopherol

Anti-inflammatory effects and hormone modulation Evidence C-grade 12-24 weeks

Nitrogen radical scavenging

Unique ability to neutralize peroxynitrite and nitrogen radicals

Gamma-form has additional methyl group for nitrogen radical trapping Evidence A-grade 2-4 weeks

Complementary to alpha-tocopherol

Provides protection in areas where alpha-tocopherol is less effective

Different antioxidant mechanisms and tissue distribution Evidence B-grade 4-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Coenzyme Q10 (CoQ10) Heart health & cellular energy 100-200mg A 10% Fish Oil (EPA/DHA) Heart & brain health 1-2g EPA/DHA A 85% Psyllium Husk Digestive health & cholesterol support 5-15g A 95% Calcium Citrate Superior absorption bone & heart health 500-1200 mg A 45% Taurine Cardiovascular & exercise support 1-3g A 95% L-Citrulline Athletic performance & circulation 3-8g A 95%

Every pair we checked

12 combinations scored by the engine

Vitamin E (Gamma-Tocopherol) + Caffeine No documented interaction either way No known interaction 70

Vitamin E (Gamma-Tocopherol) + Creatine Monohydrate No documented interaction either way No known interaction 70

Vitamin E (Gamma-Tocopherol) + Whey Protein No documented interaction either way No known interaction 70

Vitamin E (Gamma-Tocopherol) + Alpha-GPC High alpha-tocopherol may reduce gamma-tocopherol levels Needs attention 72

Vitamin E (Gamma-Tocopherol) + Iron Sulfate Iron catalyzes lipid peroxidation overwhelming antioxidants Needs attention 76

Vitamin E (Gamma-Tocopherol) + Selenium (Thyroid Support) Very high vitamin C may reduce selenium absorption Needs attention 82

Vitamin E (Gamma-Tocopherol) + Lactase Improved calcium absorption when consuming dairy Works better together 82

Vitamin E (Gamma-Tocopherol) + Bovine Collagen Essential for collagen synthesis and cross-linking Works better together 82

Vitamin E (Gamma-Tocopherol) + DHA Prevents oxidation of DHA and enhances stability Works better together 82

Vitamin E (Gamma-Tocopherol) + Vitamin E (Alpha-Tocopherol) High alpha-tocopherol may reduce gamma-tocopherol levels Needs attention 88

Vitamin E (Gamma-Tocopherol) + Vitamin D3 Regenerates tocopherols from oxidized forms Works better together 90

Vitamin E (Gamma-Tocopherol) + Calcium Carbonate Essential for calcium absorption and utilization Works better together 94

Dosage

With fat containing meal

Daily100-400 mg

Maintenance100-200 mg

Therapeutic200-600 mg

Cardiovascular200-400 mg daily

CombinationOften used with 100-400 IU alpha-tocopherol

Upper limit 1000 mg NIH ODS

Before you take it

VeganYes

When to expect it

First Effects2-4 weeks for anti-inflammatory and antioxidant benefits

Peak Benefits8-16 weeks for cardiovascular and anti-inflammatory benefits

Deficiency DevelopmentMonths to years (not well-defined)

Toxicity OnsetNo known toxicity at supplemental doses

How to measure it

$100-200

MarkerPlasma gamma-tocopherol levels

OptimalVariable, higher levels associated with benefits

Deficient belowLow plasma gamma-tocopherol levels

FrequencyOnly if optimizing vitamin E status or research purposes

What people actually reported to the FDA

CAERS, 107 reports naming it as the suspect

Most reported effects

Nausea 15

Diarrhoea 11

Headache 10

Vomiting 10

Dizziness 9

Named as the suspect 107 reports of 646 that mention it at all

Serious outcome 79% hospitalisation, emergency room or worse

Other Serious or Important Medical Event66

Hospitalization41

Visited a Health Care Provider31

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption Very high 85 of 100 · best absorbed form of this compound

Delivered daily 212.5 mg

Cost per 100 mg delivered $0.55 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Alpha Tocopherol

Complementary antioxidant protection

Different antioxidant mechanisms work together · level A

Vitamin C

Regenerates tocopherols from oxidized forms

Vitamin C recycles tocopherol radicals back to active form · level A

Selenium

Both work in antioxidant enzyme systems

Complementary roles in glutathione peroxidase function · level A

What not to take with Vitamin E (Gamma-Tocopherol)

2 documented

Alpha Tocopherol High Dose

High alpha-tocopherol may reduce gamma-tocopherol levels

Competition for absorption and tissue uptake · moderate significance

Iron Excess

Iron catalyzes lipid peroxidation overwhelming antioxidants

Pro-oxidant effects counteract antioxidant benefits · moderate significance

Medication interactions

Discuss these with a pharmacist before combining

anticoagulants-warfarin Moderate

May enhance anticoagulant effects

What to do: Monitor INR and clotting times

chemotherapy-agents Theoretical

May interfere with oxidative chemotherapy

What to do: Consult oncologist before use during treatment

statins Beneficial

May enhance cardiovascular benefits

What to do: Monitor for additive cardiovascular effects

Available forms

bioavailability compared

Best absorbed form of Vitamin E — 85% against 3 alternatives. Compare all forms →

Gamma-Tocopherol 85

Gamma-Tocopherol: Anti-inflammatory, Nitrogen radical scavenging, Cardiovascular benefits, Unique mechanisms

Food sources

before you supplement

Soybean oil 11-26mg per 100g · 80

Corn oil 17-30mg per 100g · 80

Walnuts 20-25mg per 100g · 75

Pecans 24-25mg per 100g · 75

Too little

deficiency signs

Increased inflammation markers
Enhanced oxidative stress
Poor cardiovascular health markers
Elevated nitrogen radical damage
May contribute to chronic disease risk
Accelerated aging processes

Too much

toxicity signs

No known toxicity at supplemental doses
Potential displacement of alpha-tocopherol
May enhance anticoagulant effects
Generally excellent safety profile
No established upper limit

Who benefits most

cardiovascular-disease-risk

Superior heart health benefits compared to alpha-tocopherol

100-400 mg daily

inflammatory-conditions

Unique anti-inflammatory properties not found in alpha-tocopherol

200-600 mg daily

prostate-health-focused

May provide superior prostate cancer prevention

100-300 mg daily

complete-vitamin-e-spectrum

Want comprehensive vitamin E protection beyond alpha form

100-400 mg daily (with alpha-tocopherol)

antioxidant-optimization

Advanced antioxidant protection against nitrogen radicals

200-400 mg daily

Where to buy it

compare forms first

Look for Vitamin E (Gamma-Tocopherol) at 100-400 mg per serving. The form that matters here is Gamma-Tocopherol.

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How it works

Scavenges nitrogen radicals (peroxynitrite) that alpha-tocopherol cannot
Anti-inflammatory effects through cyclooxygenase inhibition
Reduces NF-κB activation and inflammatory cytokines
Protects LDL cholesterol from oxidation
Modulates prostaglandin synthesis
Different tissue distribution than alpha-tocopherol

Key findings

what the evidence supports

Superior anti-inflammatory effects vs alpha-tocopherol (research studies)
Unique nitrogen radical scavenging ability (established biochemistry)
May be more protective for cardiovascular disease
Predominant vitamin E form in typical Western diet

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Vitamin E (Gamma-Tocopherol)?

Documented effects: Superior anti-inflammatory effects; Enhanced cardiovascular protection; Prostate health support; Nitrogen radical scavenging. More effective than alpha-tocopherol at reducing inflammation

How much Vitamin E (Gamma-Tocopherol) should you take per day?

The common daily range is 100-400 mg. By goal — maintenance: 100-200 mg; therapeutic: 200-600 mg; cardiovascular: 200-400 mg daily; combination: Often used with 100-400 IU alpha-tocopherol.

When is the best time to take Vitamin E (Gamma-Tocopherol)?

With fat containing meal. First effects are typically reported within 2-4 weeks for anti-inflammatory and antioxidant benefits.

What are the side effects of Vitamin E (Gamma-Tocopherol)?

At excessive doses: No known toxicity at supplemental doses, Potential displacement of alpha-tocopherol, May enhance anticoagulant effects, Generally excellent safety profile, No established upper limit. Safety rating at normal doses is 8 out of 10.

What should you not take with Vitamin E (Gamma-Tocopherol)?

Separate it from Alpha Tocopherol High Dose, Iron Excess by two to four hours. High alpha-tocopherol may reduce gamma-tocopherol levels

Does Vitamin E (Gamma-Tocopherol) interact with medications?

Documented interactions with anticoagulants-warfarin, chemotherapy-agents, statins. Discuss these with a pharmacist before combining.

How much Vitamin E (Gamma-Tocopherol) is too much?

The tolerable upper intake level is 1000 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: No known toxicity at supplemental doses, Potential displacement of alpha-tocopherol, May enhance anticoagulant effects.

How do you know if you need Vitamin E (Gamma-Tocopherol)?

The marker is Plasma gamma-tocopherol levels, optimal range Variable, higher levels associated with benefits. Common deficiency signs: Increased inflammation markers, Enhanced oxidative stress, Poor cardiovascular health markers, Elevated nitrogen radical damage.

Taken for

52 Heart

Fish Oil (EPA/DHA) · EPA · Olive Oil Extract