Check a pair

Vitamin B3 (NMN)

Direct NAD+ precursor that bypasses rate-limiting enzymes for maximum cellular energy and longevity benefits

Scientific nameβ-Nicotinamide Mononucleotide FormulaC11H15N2O8P Molecular weight334.22 g/mol CAS1094-61-7
88 absorption score
7 safety / 10
200 USD per month
5 documented interactions

Check it against something

Evidence level A

Vitamin B3 (NMN) with:

Compatibility score 82 out of 100
82 out of 100
Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Maximum NAD+ elevation

Most effective oral NAD+ booster available

Direct conversion to NAD+ via NMNAT enzymes Evidence A-grade 1-2 weeks

Superior longevity pathway activation

Activates sirtuins more effectively than other B3 forms

Higher NAD+ levels support all seven sirtuin enzymes Evidence B-grade 2-6 weeks

Enhanced mitochondrial biogenesis

Stimulates creation of new mitochondria

SIRT1 activation promotes PGC-1α and mitochondrial genes Evidence B-grade 4-8 weeks

Improved metabolic function

Enhances glucose metabolism and insulin sensitivity

NAD+ essential for metabolic enzyme function Evidence B-grade 4-8 weeks

Accelerated DNA repair

Supports PARP enzymes for cellular damage repair

NAD+ substrate for poly(ADP-ribose) polymerases Evidence B-grade 2-8 weeks

Every pair we checked

12 combinations scored by the engine
Vitamin B3 (NMN) + Caffeine No documented interaction either way No known interaction 70
Vitamin B3 (NMN) + Creatine Monohydrate No documented interaction either way No known interaction 70
Vitamin B3 (NMN) + Whey Protein No documented interaction either way No known interaction 70
Vitamin B3 (NMN) + Turmeric No documented interaction either way No known interaction 70
Vitamin B3 (NMN) + Vitamin D3 Prevents arterial calcification from vitamin D Works better together 78
Vitamin B3 (NMN) + Pterostilbene-Resveratrol Anti-Aging and Longevity Complex Synergistic sirtuin activation and longevity benefits Works better together 82
Vitamin B3 (NMN) + Lactase Improved calcium absorption when consuming dairy Works better together 82
Vitamin B3 (NMN) + Bovine Collagen Essential for collagen synthesis and cross-linking Works better together 82
Vitamin B3 (NMN) + DHA Prevents oxidation of DHA and enhances stability Works better together 82
Vitamin B3 (NMN) + Quercetin Both support cellular longevity and mitochondrial function Works better together 90
Vitamin B3 (NMN) + Fish Oil (EPA/DHA) Protects fish oil from oxidation Works better together 90
Vitamin B3 (NMN) + Calcium Carbonate Essential for calcium absorption and utilization Works better together 94

Dosage

Morning empty stomach
Daily250-500 mg
Maintenance125-250 mg
Therapeutic250-1000 mg
Research equivalent500-1000 mg
Cost considerationStart low due to extreme cost
Upper limit 35 mg NIH ODS

Before you take it

VeganYes

When to expect it

First Effects1-2 weeks for energy and metabolic improvements
Peak Benefits8-16 weeks for anti-aging and longevity benefits
Deficiency DevelopmentSame as other B3 forms
Toxicity OnsetNo known toxicity in current human studies

How to measure it

$200-500
MarkerWhole blood NAD+ or NAD+/NADH ratio
OptimalAge-adjusted optimal levels
FrequencyEvery 2-4 months when optimizing longevity protocols

What people actually reported to the FDA

CAERS, 35 reports naming it as the suspect

Most reported effects

Erythema 13
Flushing 12
Pruritus 10
Dizziness 10
Dyspnoea 9
Named as the suspect 35 reports of 52 that mention it at all
Serious outcome 82% hospitalisation, emergency room or worse
Other Serious or Important Medical Event26
Visited Emergency Room15
Life Threatening8

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not
Absorption Very high 88 of 100 · best absorbed form of this compound
Delivered daily 330 mg
Cost per 100 mg delivered $2.02 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented
+
Resveratrol

Synergistic sirtuin activation and longevity benefits

Resveratrol activates sirtuins, NMN provides NAD+ substrate · level A
+
Quercetin

Both support cellular longevity and mitochondrial function

Complementary pathways for cellular health · level B
+
Exercise

Exercise enhances NMN benefits on mitochondrial function

Both stimulate mitochondrial biogenesis · level A

What not to take with Vitamin B3 (NMN)

2 documented
!
Alcohol Chronic

Severely counteracts NMN benefits by depleting NAD+

Alcohol metabolism consumes large amounts of NAD+ · major significance
!
Cd38 High Activity

CD38 enzyme degrades NAD+ faster with aging

Age-related CD38 increase limits NAD+ accumulation · moderate significance

Medication interactions

Discuss these with a pharmacist before combining
cancer-treatments Theoretical

Theoretical concern about enhanced DNA repair in cancer cells

What to do: Avoid during active cancer treatment without oncologist approval

diabetes-medications Beneficial

May improve insulin sensitivity

What to do: Monitor blood glucose for improvements

Available forms

bioavailability compared
β-Nicotinamide Mononucleotide 88

β-Nicotinamide Mononucleotide: Direct NAD+ precursor, Maximum efficacy, Research-backed, Longevity focus

Food sources

before you supplement
Edamame (highest natural source) 0.47-1.88 mg/100g · 60
Broccoli 0.25-1.12 mg/100g · 60
Avocado 0.36-1.60 mg/100g · 60
Note: Food sources provide minimal amounts vs supplement doses Supplementation necessary for therapeutic effects · 88

Too little

deficiency signs
  • Same as NAD+ depletion:
  • Severe fatigue and energy crashes
  • Accelerated aging signs
  • Poor metabolic function
  • Reduced exercise capacity
  • Cognitive decline
  • Poor stress tolerance

Too much

toxicity signs
  • No known toxicity in current human studies
  • Mild nausea reported by some users
  • No serious adverse events reported
  • Excellent safety profile in animal studies
  • Long-term human effects unknown

Who benefits most

serious-longevity-enthusiasts

Maximum NAD+ boost for anti-aging protocols

250-1000 mg daily
advanced-biohackers

Cutting-edge supplement for cellular optimization

500-1000 mg daily
metabolic-health-focus

Superior metabolic benefits and insulin sensitivity

250-500 mg daily
high-net-worth-health

Premium health investment regardless of cost

500-1000 mg daily
age-related-decline

Combat cellular aging and energy decline

250-500 mg daily

Where to buy it

compare forms first

Look for Vitamin B3 (NMN) at 250-500 mg per serving. The form that matters here is β-Nicotinamide Mononucleotide.

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What else affects it

Beyond other supplements
+
Exercise

Exercise enhances NMN benefits on mitochondrial function

Both stimulate mitochondrial biogenesis
!
Alcohol chronic

Severely counteracts NMN benefits by depleting NAD+

Alcohol metabolism consumes large amounts of NAD+

How it works

  • Direct conversion to NAD+ via nicotinamide mononucleotide adenylyltransferase
  • Bypasses rate-limiting NAMPT enzyme completely
  • May utilize specific NMN transporters (Slc12a8)
  • One enzymatic step away from NAD+ (closest oral precursor)
  • Rapidly converted to NAD+ in tissues
  • Maximum sirtuin and PARP enzyme activation potential

Key findings

what the evidence supports
  • Increases NAD+ levels by 38% in humans (Nature Metabolism 2021)
  • Improves muscle insulin sensitivity in prediabetic women
  • Reverses age-related decline in animal studies
  • Superior to NR for some tissues in direct comparisons

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Vitamin B3 (NMN)?

Documented effects: Maximum NAD+ elevation; Superior longevity pathway activation; Enhanced mitochondrial biogenesis; Improved metabolic function. Most effective oral NAD+ booster available

How much Vitamin B3 (NMN) should you take per day?

The common daily range is 250-500 mg. By goal — maintenance: 125-250 mg; therapeutic: 250-1000 mg; research equivalent: 500-1000 mg; cost consideration: Start low due to extreme cost.

When is the best time to take Vitamin B3 (NMN)?

Morning empty stomach. First effects are typically reported within 1-2 weeks for energy and metabolic improvements.

What are the side effects of Vitamin B3 (NMN)?

At excessive doses: No known toxicity in current human studies, Mild nausea reported by some users, No serious adverse events reported, Excellent safety profile in animal studies, Long-term human effects unknown. Safety rating at normal doses is 7 out of 10.

What should you not take with Vitamin B3 (NMN)?

Separate it from Alcohol Chronic, Cd38 High Activity by two to four hours. Severely counteracts NMN benefits by depleting NAD+

Does Vitamin B3 (NMN) interact with medications?

Documented interactions with cancer-treatments, diabetes-medications. Discuss these with a pharmacist before combining.

How much Vitamin B3 (NMN) is too much?

The tolerable upper intake level is 35 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: No known toxicity in current human studies, Mild nausea reported by some users, No serious adverse events reported.

How do you know if you need Vitamin B3 (NMN)?

The marker is Whole blood NAD+ or NAD+/NADH ratio, optimal range Age-adjusted optimal levels. Common deficiency signs: Same as NAD+ depletion:, Severe fatigue and energy crashes, Accelerated aging signs, Poor metabolic function.