Red Clover

Rich source of isoflavones providing natural phytoestrogen support for menopausal symptoms and women's hormonal health

Scientific nameTrifolium pratense FormulaC16H12O4 (genistein) Molecular weight268.26 g/mol CAS446-72-0

65 absorption score

7 safety / 10

30 USD per month

5 documented interactions

Check it against something

Evidence level C

Red Clover with:

75 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Menopausal symptom relief

Reduces hot flashes, night sweats, and other menopausal symptoms

Isoflavones provide mild estrogenic effects to compensate for declining estrogen Evidence B-grade 6-12 weeks

Bone health support

Supports bone density and reduces bone loss in postmenopausal women

Phytoestrogens help maintain bone metabolism and calcium retention Evidence B-grade 6-12 months

Cardiovascular health support

Supports heart health and healthy cholesterol levels

Isoflavones improve lipid profiles and support vascular function Evidence C-grade 3-6 months

Skin health and elasticity

Supports skin health and may improve skin elasticity

Phytoestrogens support collagen production and skin hydration Evidence C-grade 3-6 months

Antioxidant protection

Provides antioxidant support for cellular health

Isoflavones neutralize free radicals and protect against oxidative damage Evidence B-grade 4-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Melatonin Sleep support & circadian rhythm 0.5-3mg A 50% Boron - Essential Trace Mineral for Bone and Hormone Health Bone health & hormone support 3-10mg daily B 85% Iodine (Thyroid Support) Thyroid hormone production 150-300mcg A 95% Iodine (Potassium Iodide) Essential thyroid & metabolism support 150-300 mcg A 95% Fenugreek Blood sugar control & testosterone support 500-1000mg B 75% T4 Levothyroxine - Primary Thyroid Hormone Thyroid hormone replacement PRESCRIPTION ONLY - 25-200mcg A 80%

Every pair we checked

12 combinations scored by the engine

Red Clover + Caffeine No documented interaction either way No known interaction 70

Red Clover + Creatine Monohydrate No documented interaction either way No known interaction 70

Red Clover + Whey Protein No documented interaction either way No known interaction 70

Red Clover + Lactase No documented interaction either way No known interaction 70

Red Clover + Bovine Collagen No documented interaction either way No known interaction 70

Red Clover + DHA No documented interaction either way No known interaction 70

Red Clover + Turmeric No documented interaction either way No known interaction 70

Red Clover + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70

Red Clover + Calcium Carbonate Enhanced bone health support Works better together 75

Red Clover + Vitamin D3 Improved bone health and calcium absorption Works better together 75

Red Clover + Magnesium Oxide Enhanced bone health support Works better together 75

Red Clover + Black Cohosh Comprehensive menopausal symptom relief Works better together 80

Dosage

With meals

Daily80-320mg extract

Menopause support40-160mg isoflavones daily

Bone health40-80mg isoflavones daily

Cardiovascular support40-80mg isoflavones daily

Antioxidant support40mg isoflavones daily

Before you take it

VeganYes

When to expect it

First Effects6-12 weeks for menopausal symptom relief

Peak Benefits6-12 months for sustained hormonal support and bone health

Deficiency DevelopmentNot applicable - herbal supplement

Toxicity OnsetRare, mainly contraindications

How to measure it

$200-400

MarkerEstradiol, bone markers (CTX, P1NP), lipid profile, clotting factors

OptimalImproved bone markers, stable lipids, normal clotting

Deficient belowNot applicable for herbal supplement

FrequencyEvery 6-12 months for safety and effectiveness monitoring

What people actually reported to the FDA

CAERS, 6 reports naming it as the suspect

Most reported effects

Palpitations 2

Breast cancer 1

Carcinoid tumour 1

Alanine aminotransferase increased 1

Alpha-1 anti-trypsin decreased 1

Named as the suspect 6 reports of 10 that mention it at all

Serious outcome 67% hospitalisation, emergency room or worse

Hospitalization4

Visited a Health Care Provider3

Other Serious or Important Medical Event2

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption High 65 of 100 · absorbs well relative to other forms

Delivered daily 130 mg

Cost per 100 mg delivered $0.77 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Calcium Magnesium

Enhanced bone health support

Red clover supports bone metabolism while minerals provide building blocks · level C

Vitamin D3

Improved bone health and calcium absorption

Vitamin D enhances calcium absorption that red clover helps retain · level C

Black Cohosh

Comprehensive menopausal symptom relief

Complementary mechanisms for hot flash and symptom reduction · level C

What not to take with Red Clover

2 documented

Hormone Replacement Therapy

May interfere with HRT or increase estrogenic effects

Both provide estrogenic activity and may be additive · high significance

Tamoxifen Anti Estrogens

May interfere with anti-estrogen medications

Phytoestrogens may oppose anti-estrogen therapy · high significance

Medication interactions

Discuss these with a pharmacist before combining

hormone-replacement-therapy Moderate

May enhance or interfere with hormone therapy

What to do: Consult healthcare provider

blood-thinning-medications Moderate

May affect blood clotting parameters

What to do: Monitor bleeding parameters

tamoxifen High

May interfere with anti-estrogen therapy

What to do: Avoid concurrent use

Available forms

bioavailability compared

Red Clover Extract (Standardized 8-40% Isoflavones) 65

Red Clover Extract (Standardized 8-40% Isoflavones): Natural phytoestrogen source, Menopause support, Bone health benefits, Antioxidant activity

Food sources

before you supplement

Red clover flowers (fresh) Natural isoflavone content · 60

Red clover tea Moderate isoflavone content · 55

Standardized extracts Concentrated isoflavones (8-40%) · 65

Not found in common foods Specific herb preparation required · N/A

Too little

deficiency signs

Not applicable (herbal supplement, not essential nutrient):
General symptoms addressed by red clover:
Severe menopausal symptoms including hot flashes
Rapid bone loss in postmenopausal women
Poor cardiovascular health markers
Declining skin health and elasticity
High oxidative stress and cellular damage

Too much

toxicity signs

Generally safe with some considerations:
Increased bleeding or clotting risk in susceptible individuals
Breast tenderness or hormonal effects
Digestive upset with high doses
Contraindicated in hormone-sensitive conditions

Who benefits most

menopause-hot-flashes

Natural relief from hot flashes and menopausal symptoms

40-160mg isoflavones daily (80-320mg extract)

bone-health-postmenopausal

Bone health support for postmenopausal women at risk of osteoporosis

40-80mg isoflavones daily

cardiovascular-health-women

Heart health support for postmenopausal women

40-80mg isoflavones daily

skin-health-aging

Skin health support for aging and postmenopausal women

40-80mg isoflavones daily

antioxidant-protection

General antioxidant support for cellular health

40mg isoflavones daily

Where to buy it

compare forms first

Look for Red Clover at 80-320mg extract per serving. The form that matters here is Red Clover Extract (Standardized 8-40% Isoflavones).

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How it works

Isoflavones bind to estrogen receptors providing mild estrogenic effects
Phytoestrogens help compensate for declining estrogen in menopause
Genistein and daidzein support bone metabolism and reduce bone resorption
Isoflavones improve lipid profiles and support cardiovascular health
Antioxidant activity protects cells from oxidative damage and aging
Supports collagen synthesis and skin health through estrogenic activity

Key findings

what the evidence supports

Moderate evidence for menopausal symptom relief, especially hot flashes
Good research on bone health benefits in postmenopausal women
Promising cardiovascular health effects
Important safety considerations for hormone-sensitive conditions

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Red Clover?

Documented effects: Menopausal symptom relief; Bone health support; Cardiovascular health support; Skin health and elasticity. Reduces hot flashes, night sweats, and other menopausal symptoms

How much Red Clover should you take per day?

The common daily range is 80-320mg extract. By goal — menopause support: 40-160mg isoflavones daily; bone health: 40-80mg isoflavones daily; cardiovascular support: 40-80mg isoflavones daily; antioxidant support: 40mg isoflavones daily.

When is the best time to take Red Clover?

With meals. First effects are typically reported within 6-12 weeks for menopausal symptom relief.

What are the side effects of Red Clover?

At excessive doses: Generally safe with some considerations:, Increased bleeding or clotting risk in susceptible individuals, Breast tenderness or hormonal effects, Digestive upset with high doses, Contraindicated in hormone-sensitive conditions. Safety rating at normal doses is 7 out of 10.

What should you not take with Red Clover?

Separate it from Hormone Replacement Therapy, Tamoxifen Anti Estrogens by two to four hours. May interfere with HRT or increase estrogenic effects

Does Red Clover interact with medications?

Documented interactions with hormone-replacement-therapy, blood-thinning-medications, tamoxifen. Discuss these with a pharmacist before combining.

How do you know if you need Red Clover?

The marker is Estradiol, bone markers (CTX, P1NP), lipid profile, clotting factors, optimal range Improved bone markers, stable lipids, normal clotting. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by red clover:, Severe menopausal symptoms including hot flashes, Rapid bone loss in postmenopausal women.

Taken for

27 Hormones

Melatonin · Vitamin B6 (Pyridoxine HCl) · Vitamin B6 (P5P)