Enhanced memory and learning
Significantly improves memory formation and learning capacity
Piracetam
The first nootropic compound ever synthesized, enhancing cognitive function through modulation of AMPA receptors and neurotransmission
Scientific name2-oxo-1-pyrrolidineacetamide
FormulaC6H10N2O2
Molecular weight142.16 g/mol
CAS7491-74-9
95
absorption score
9
safety / 10
20
USD per month
5
documented interactions
Check it against something
Piracetam with:
- Alpha-GPC
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
82
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimImproved cognitive function
Enhances overall cognitive performance and mental clarity
Neuroprotective effects
Protects brain cells from damage and supports healthy aging
Enhanced brain connectivity
Improves communication between brain hemispheres
Support for age-related cognitive decline
May help with mild cognitive impairment and dementia
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
L-Theanine
Calm focus & stress relief
100-400mg
B
90%
Vitamin B8 (Inositol)
Mental health & PCOS support
2-18g (condition dependent)
B
95%
SAM-e
Mood support & liver health
400-800mg
A
70%
Lithium Orotate
Mood & brain support
1-20mg
C
60%
Every pair we checked
12 combinations scored by the engine
Piracetam + Caffeine
No documented interaction either way
No known interaction
70
Piracetam + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Piracetam + Vitamin D3
No documented interaction either way
No known interaction
70
Piracetam + Calcium Carbonate
No documented interaction either way
No known interaction
70
Piracetam + Whey Protein
No documented interaction either way
No known interaction
70
Piracetam + Lactase
No documented interaction either way
No known interaction
70
Piracetam + Bovine Collagen
No documented interaction either way
No known interaction
70
Piracetam + DHA
No documented interaction either way
No known interaction
70
Piracetam + Turmeric
No documented interaction either way
No known interaction
70
Piracetam + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced membrane fluidity and cognitive function
Works better together
78
Piracetam + Choline (Bitartrate)
Essential for preventing headaches and maximizing benefits
Works better together
82
Piracetam + Alpha-GPC
Enhanced cognitive function and reduced side effects
Works better together
82
Dosage
Daily1600-3200mg
Cognitive enhancement1600-3200mg daily
Learning support1600-2400mg daily
Neuroprotection2400-4800mg daily
Dementia support2400-4800mg daily
Before you take it
Restricted substance. Not approved by the FDA as a dietary supplement.
Pregnancyavoid
When to expect it
First Effects2-4 weeks for cognitive benefits
Peak Benefits6-12 weeks for sustained cognitive enhancement
Deficiency DevelopmentNot applicable - synthetic compound
Toxicity OnsetVery rare, excellent safety profile
How to measure it
MarkerNot routinely measured - assess through cognitive function
OptimalEnhanced cognitive performance markers
Deficient belowNot applicable for synthetic compound
FrequencyMonitor through cognitive assessment
What people actually reported to the FDA
CAERS, 2 reports naming it as the suspectMost reported effects
Named as the suspect
2 reports
of 2 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Disability1
Other Serious or Important Medical Event1
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 95 of 100 · best absorbed form of this compound
Delivered daily
2280 mg
Cost per 100 mg delivered
$0.03 comparative — uses the absorption score, not a measured percentage
Works better with
+
Choline Sources
Essential for preventing headaches and maximizing benefits
Piracetam increases choline demand for acetylcholine synthesis · level A
+
Alpha Gpc
Enhanced cognitive function and reduced side effects
Provides choline for increased acetylcholine demands · level A
+
Omega 3 Fatty Acids
Enhanced membrane fluidity and cognitive function
Both support neuronal membrane function · level BWhat not to take with Piracetam
!
Alcohol
May interfere with cognitive benefits
Alcohol impairs memory formation and neuroplasticity · moderate significance
!
Anticholinergic Drugs
May counteract cognitive benefits
Opposing effects on acetylcholine system · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay slightly increase bleeding risk
What to do: Monitor bleeding parameters
May enhance thyroid hormone effects
What to do: Monitor thyroid function
May enhance stimulant effects
What to do: Monitor for overstimulation
Available forms
Piracetam (racetam): Excellent research, High safety, Cognitive enhancement, Cumulative effects
Food sources
Not found in natural foods
Synthetic compound only · N/A
Supplements only
800mg per capsule typically · 95
Prescription medications (Europe)
800mg tablets · 95
Bulk powder form
Measured doses · 95
Too little
- Not applicable (synthetic compound):
- Symptoms addressed by piracetam:
- Poor memory and learning ability
- Reduced cognitive performance
- Age-related cognitive decline
- Poor brain connectivity
- Difficulty with complex mental tasks
Too much
- Extremely safe, potential effects:
- Headaches (most common)
- Overstimulation and anxiety
- Insomnia if taken late
- Digestive upset
- Dizziness (rare)
Who benefits most
cognitive-enhancement
Excellent for improving memory and learning capacity
1600-3200mg daily
students-learning
Enhances learning ability and memory formation
1600-2400mg daily
aging-neuroprotection
Supports healthy brain aging and cognitive function
2400-4800mg daily
dementia-mild-cognitive-impairment
May help with age-related cognitive decline
2400-4800mg daily
brain-injury-recovery
May support recovery from traumatic brain injury
2400-4800mg dailyWhat else affects it
Beyond other supplements
!
Alcohol
May interfere with cognitive benefits
Alcohol impairs memory formation and neuroplasticityHow it works
- Modulates AMPA receptors enhancing glutamate neurotransmission
- Increases neuronal membrane fluidity
- Enhances brain connectivity and hemispheric communication
- Supports neuroplasticity and synaptic plasticity
- Improves mitochondrial function in neurons
- Increases choline uptake and acetylcholine synthesis
Key findings
what the evidence supports- Extensive evidence for cognitive enhancement and memory improvement
- Excellent safety profile with over 50 years of use
- Cumulative benefits with long-term use
- Most effective when combined with choline sources
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Piracetam?
Documented effects: Enhanced memory and learning; Improved cognitive function; Neuroprotective effects; Enhanced brain connectivity. Significantly improves memory formation and learning capacity
How much Piracetam should you take per day?
The common daily range is 1600-3200mg. By goal — cognitive enhancement: 1600-3200mg daily; learning support: 1600-2400mg daily; neuroprotection: 2400-4800mg daily; dementia support: 2400-4800mg daily.
When is the best time to take Piracetam?
Divided doses with meals. First effects are typically reported within 2-4 weeks for cognitive benefits.
What are the side effects of Piracetam?
At excessive doses: Extremely safe, potential effects:, Headaches (most common), Overstimulation and anxiety, Insomnia if taken late, Digestive upset. Safety rating at normal doses is 9 out of 10.
What should you not take with Piracetam?
Separate it from Alcohol, Anticholinergic Drugs by two to four hours. May interfere with cognitive benefits
Does Piracetam interact with medications?
Documented interactions with blood-thinners, thyroid-hormones, stimulants. Discuss these with a pharmacist before combining.
How do you know if you need Piracetam?
The marker is Not routinely measured - assess through cognitive function, optimal range Enhanced cognitive performance markers. Common deficiency signs: Not applicable (synthetic compound):, Symptoms addressed by piracetam:, Poor memory and learning ability, Reduced cognitive performance.