Phenylpiracetam

Potent racetam nootropic with added phenyl group, providing enhanced cognitive function and physical performance benefits

Scientific name2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide FormulaC12H14N2O2 Molecular weight218.25 g/mol CAS77472-70-9

85 absorption score

7 safety / 10

50 USD per month

5 documented interactions

Check it against something

Evidence level C

Phenylpiracetam with:

75 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Enhanced focus and concentration

Significantly improves attention span and mental focus

Modulates AMPA receptors and increases dopamine sensitivity Evidence B-grade 1-3 hours

Improved physical performance

Enhances endurance and reduces fatigue during physical activity

Increases locomotor activity and reduces perception of effort Evidence B-grade 2-6 hours

Enhanced memory and learning

Improves memory formation and cognitive performance

Enhances neuroplasticity and synaptic transmission Evidence B-grade 2-4 hours

Increased mental energy and alertness

Provides sustained mental energy without jitters

Optimizes neurotransmitter function and brain energy metabolism Evidence B-grade 2-8 hours

Cold tolerance and adaptation

Improves tolerance to cold environments and stress

Enhances stress adaptation and thermoregulation Evidence C-grade 1-4 hours

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Creatine Monohydrate Strength & power enhancement 3-5g A 95% Calcium Bone health & muscle function 1,000-1,200 mg A 30% Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 90% Vitamin B12 (Cyanocobalamin) Energy & nerve support 250-1000 mcg A 70% Fish Oil (EPA/DHA) Heart & brain health 1-2g EPA/DHA A 85% L-Theanine Calm focus & stress relief 100-400mg B 90%

Every pair we checked

12 combinations scored by the engine

Phenylpiracetam + Creatine Monohydrate No documented interaction either way No known interaction 70

Phenylpiracetam + Vitamin D3 No documented interaction either way No known interaction 70

Phenylpiracetam + Calcium Carbonate No documented interaction either way No known interaction 70

Phenylpiracetam + Whey Protein No documented interaction either way No known interaction 70

Phenylpiracetam + Lactase No documented interaction either way No known interaction 70

Phenylpiracetam + Bovine Collagen No documented interaction either way No known interaction 70

Phenylpiracetam + DHA No documented interaction either way No known interaction 70

Phenylpiracetam + Turmeric No documented interaction either way No known interaction 70

Phenylpiracetam + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70

Phenylpiracetam + Alpha-GPC Enhanced cognitive function and reduced side effects Works better together 75

Phenylpiracetam + Caffeine Enhanced alertness and focus (use cautiously) Works better together 75

Phenylpiracetam + L-Theanine May smooth effects and reduce anxiety Works better together 75

Dosage

Morning or pre workout

Daily100-200mg

Cognitive enhancement100-200mg daily

Physical performance100-200mg pre-workout

Study enhancement100-200mg daily

Competition preparation100-200mg before events

Before you take it

Restricted substance. Not approved by the FDA as a dietary supplement.

Pregnancyavoid

When to expect it

First Effects1-2 hours for cognitive and physical benefits

Peak Benefits3-6 hours for optimal enhancement

Deficiency DevelopmentNot applicable - synthetic compound

Toxicity OnsetRare but possible with high doses

How to measure it

Not applicable

MarkerNot routinely measured - assess through performance

OptimalEnhanced cognitive and physical performance

Deficient belowNot applicable for synthetic compound

FrequencyMonitor through performance assessment and side effects

What people actually reported to the FDA

CAERS, 1 reports naming it as the suspect

Most reported effects

Chest discomfort 1

Dizziness 1

Headache 1

Nausea 1

Sedation 1

Named as the suspect 1 reports of 1 that mention it at all

Serious outcome 100% hospitalisation, emergency room or worse

Other Serious or Important Medical Event1

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption Very high 85 of 100 · best absorbed form of this compound

Delivered daily 127.5 mg

Cost per 100 mg delivered $1.31 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Alpha Gpc

Enhanced cognitive function and reduced side effects

Provides choline for increased acetylcholine demands · level C

Caffeine

Enhanced alertness and focus (use cautiously)

Complementary stimulant effects · level C

L Theanine

May smooth effects and reduce anxiety

Calming effects without sedation · level C

What not to take with Phenylpiracetam

2 documented

Alcohol

May interfere with cognitive and physical benefits

Alcohol impairs cognitive function and physical performance · moderate significance

Depressants

May counteract stimulant and cognitive effects

Opposing effects on brain activity · moderate significance

Medication interactions

Discuss these with a pharmacist before combining

stimulants Moderate

May enhance stimulant effects

What to do: Monitor for overstimulation

blood-thinners Minor

Theoretical interaction - limited data

What to do: Monitor bleeding parameters

antidepressants Unknown

May interact with neurotransmitter systems

What to do: Monitor mood and effects

Available forms

bioavailability compared

Phenylpiracetam (racetam with phenyl group) 85

Phenylpiracetam (racetam with phenyl group): Very potent, Dual cognitive/physical benefits, Fast-acting, High bioavailability

Food sources

before you supplement

Not found in natural foods Synthetic compound only · N/A

Supplements only 100mg per capsule typically · 85

Bulk powder form Measured doses · 85

Prescription in some countries 100mg tablets · 85

Too little

deficiency signs

Not applicable (synthetic compound):
Symptoms addressed by phenylpiracetam:
Poor focus and concentration
Reduced cognitive performance
Physical fatigue and poor endurance
Lack of mental energy
Poor stress tolerance

Too much

toxicity signs

Generally safe but potential effects:
Anxiety and overstimulation
Insomnia and sleep disturbances
Headaches
Irritability and mood changes
Tolerance development

Who benefits most

high-performance-cognitive-enhancement

Excellent for demanding mental tasks requiring sustained focus

100-200mg daily

athletic-performance-enhancement

Improves both mental focus and physical endurance

100-200mg pre-workout

students-exam-preparation

Enhances focus, memory, and mental endurance for studying

100-200mg daily

competitive-gaming-esports

Improves reaction time, focus, and sustained performance

100-200mg before competition

cold-environment-adaptation

May improve tolerance to cold stress and environments

100-200mg as needed

What else affects it

Beyond other supplements

Alcohol

May interfere with cognitive and physical benefits

Alcohol impairs cognitive function and physical performance

How it works

Modulates AMPA receptors more potently than piracetam
Increases dopamine and norepinephrine sensitivity
Enhances neuroplasticity and synaptic transmission
Improves mitochondrial function and energy metabolism
Crosses blood-brain barrier more efficiently than piracetam
Affects locomotor activity and physical performance

Key findings

what the evidence supports

Promising evidence for cognitive and physical enhancement
Significantly more potent than regular piracetam
Banned by WADA indicating performance-enhancing effects
Limited long-term safety data due to recent development

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Phenylpiracetam?

Documented effects: Enhanced focus and concentration; Improved physical performance; Enhanced memory and learning; Increased mental energy and alertness. Significantly improves attention span and mental focus

How much Phenylpiracetam should you take per day?

The common daily range is 100-200mg. By goal — cognitive enhancement: 100-200mg daily; physical performance: 100-200mg pre-workout; study enhancement: 100-200mg daily; competition preparation: 100-200mg before events.

When is the best time to take Phenylpiracetam?

Morning or pre workout. First effects are typically reported within 1-2 hours for cognitive and physical benefits.

What are the side effects of Phenylpiracetam?

At excessive doses: Generally safe but potential effects:, Anxiety and overstimulation, Insomnia and sleep disturbances, Headaches, Irritability and mood changes. Safety rating at normal doses is 7 out of 10.

What should you not take with Phenylpiracetam?

Separate it from Alcohol, Depressants by two to four hours. May interfere with cognitive and physical benefits

Does Phenylpiracetam interact with medications?

Documented interactions with stimulants, blood-thinners, antidepressants. Discuss these with a pharmacist before combining.

How do you know if you need Phenylpiracetam?

The marker is Not routinely measured - assess through performance, optimal range Enhanced cognitive and physical performance. Common deficiency signs: Not applicable (synthetic compound):, Symptoms addressed by phenylpiracetam:, Poor focus and concentration, Reduced cognitive performance.

Taken for

52 Brain & Focus

Caffeine · DHA · Fish Oil (EPA/DHA)

43 Performance

Caffeine · Creatine Monohydrate · Whey Protein