Powerful cognitive enhancement
Dramatically improves memory, learning, and cognitive performance
Noopept
Potent synthetic nootropic peptide with neuroprotective properties, significantly more potent than piracetam for cognitive enhancement
Scientific nameN-phenylacetyl-L-prolylglycine ethyl ester
FormulaC17H22N2O4
Molecular weight318.37 g/mol
CAS157115-85-0
90
absorption score
7
safety / 10
35
USD per month
5
documented interactions
Check it against something
Noopept with:
- Alpha-GPC
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
75
out of 100
Works better together
Take together — same timing window amplifies the synergy.
What it does
mechanism and evidence for each claimSuperior neuroprotection
Protects brain cells from damage and supports healthy aging
Enhanced neuroplasticity
Improves brain's ability to form new connections and adapt
Improved focus and concentration
Enhances attention span and mental clarity
Stress resilience and anxiety reduction
May help manage stress and reduce anxiety symptoms
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
L-Theanine
Calm focus & stress relief
100-400mg
B
90%
Vitamin B8 (Inositol)
Mental health & PCOS support
2-18g (condition dependent)
B
95%
SAM-e
Mood support & liver health
400-800mg
A
70%
Lithium Orotate
Mood & brain support
1-20mg
C
60%
Every pair we checked
12 combinations scored by the engine
Noopept + Caffeine
No documented interaction either way
No known interaction
70
Noopept + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Noopept + Calcium Carbonate
No documented interaction either way
No known interaction
70
Noopept + Whey Protein
No documented interaction either way
No known interaction
70
Noopept + Lactase
No documented interaction either way
No known interaction
70
Noopept + Bovine Collagen
No documented interaction either way
No known interaction
70
Noopept + DHA
No documented interaction either way
No known interaction
70
Noopept + Turmeric
No documented interaction either way
No known interaction
70
Noopept + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Noopept + Alpha-GPC
Enhanced cognitive function and reduced side effects
Works better together
75
Noopept + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced neuroprotection and brain health
Works better together
75
Noopept + Vitamin D3
Enhanced energy metabolism and cognitive function
Works better together
75
Dosage
Daily10-30mg
Cognitive enhancement10-30mg daily
Neuroprotection10-20mg daily
Learning support10-20mg daily
Advanced users20-30mg daily
When to expect it
First Effects1-2 weeks for cognitive benefits
Peak Benefits4-8 weeks for sustained enhancement and neuroprotection
Deficiency DevelopmentNot applicable - synthetic compound
Toxicity OnsetRare but possible with high doses or sensitive individuals
How to measure it
MarkerNot routinely measured - assess through cognitive function
OptimalEnhanced cognitive performance markers
Deficient belowNot applicable for synthetic compound
FrequencyMonitor through cognitive assessment and side effects
What people actually reported to the FDA
CAERS, 4 reports naming it as the suspectMost reported effects
Named as the suspect
4 reports
of 4 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Hospitalization2
Visited Emergency Room2
Other Serious or Important Medical Event2
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 90 of 100 · best absorbed form of this compound
Delivered daily
18 mg
Cost per 100 mg delivered
$6.48 comparative — uses the absorption score, not a measured percentage
Works better with
+
Alpha Gpc
Enhanced cognitive function and reduced side effects
Provides choline for increased acetylcholine demands · level C
+
Omega 3 Fatty Acids
Enhanced neuroprotection and brain health
Complementary mechanisms for brain health · level C
+
B Complex Vitamins
Enhanced energy metabolism and cognitive function
Support for increased brain metabolic demands · level CWhat not to take with Noopept
!
Alcohol
May interfere with cognitive benefits
Alcohol impairs neuroplasticity and brain function · moderate significance
!
Depressants
May counteract cognitive enhancement effects
Opposing effects on brain activity · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance stimulant effects
What to do: Monitor for overstimulation
Theoretical interaction - limited data
What to do: Monitor bleeding parameters
May interact with neurotransmitter systems
What to do: Consult healthcare provider
Available forms
Noopept (synthetic peptide): Extremely potent, Fast-acting, Neuroprotective, Small doses needed
Food sources
Not found in natural foods
Synthetic compound only · N/A
Supplements only
10-30mg per capsule · 90
Bulk powder form
Measured microdoses · 90
Prescription in some countries
10-20mg tablets · 90
Too little
- Not applicable (synthetic compound):
- Symptoms addressed by noopept:
- Poor cognitive performance and memory
- Reduced learning capacity
- Age-related cognitive decline
- Poor focus and concentration
- Lack of mental clarity
Too much
- Limited data but potential effects:
- Headaches and overstimulation
- Insomnia and sleep disturbances
- Anxiety and restlessness
- Digestive upset
- Mood changes
Who benefits most
advanced-cognitive-enhancement
Extremely potent cognitive enhancer for experienced users
10-30mg daily
neuroprotection-aging
Powerful neuroprotective effects for brain health
10-20mg daily
students-intense-learning
Enhances learning capacity and memory consolidation
10-20mg daily
cognitive-decline-prevention
May help prevent age-related cognitive decline
10-20mg daily
high-performance-professionals
Enhances focus and cognitive performance under pressure
10-20mg dailyWhere to buy it
Look for Noopept at 10-30mg per serving. The form that matters here is Noopept (synthetic peptide).
Find on Amazon
Affiliate link — we may earn a commission at no cost to you.
What else affects it
Beyond other supplements
!
Alcohol
May interfere with cognitive benefits
Alcohol impairs neuroplasticity and brain functionHow it works
- Modulates AMPA and NMDA glutamate receptors
- Increases BDNF and NGF production
- Enhances neuroplasticity and synaptic plasticity
- Metabolizes into cycloprolylglycine (active neuropeptide)
- Provides potent antioxidant and neuroprotective effects
- Optimizes neurotransmitter balance and brain connectivity
Key findings
what the evidence supports- Promising evidence for cognitive enhancement and neuroprotection
- Extremely potent - effective at very low doses
- Limited long-term safety data due to recent development
- Requires careful dosing due to high potency
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Noopept?
Documented effects: Powerful cognitive enhancement; Superior neuroprotection; Enhanced neuroplasticity; Improved focus and concentration. Dramatically improves memory, learning, and cognitive performance
How much Noopept should you take per day?
The common daily range is 10-30mg. By goal — cognitive enhancement: 10-30mg daily; neuroprotection: 10-20mg daily; learning support: 10-20mg daily; advanced users: 20-30mg daily.
When is the best time to take Noopept?
Morning with food. First effects are typically reported within 1-2 weeks for cognitive benefits.
What are the side effects of Noopept?
At excessive doses: Limited data but potential effects:, Headaches and overstimulation, Insomnia and sleep disturbances, Anxiety and restlessness, Digestive upset. Safety rating at normal doses is 7 out of 10.
What should you not take with Noopept?
Separate it from Alcohol, Depressants by two to four hours. May interfere with cognitive benefits
Does Noopept interact with medications?
Documented interactions with stimulants, blood-thinners, psychiatric-medications. Discuss these with a pharmacist before combining.
How do you know if you need Noopept?
The marker is Not routinely measured - assess through cognitive function, optimal range Enhanced cognitive performance markers. Common deficiency signs: Not applicable (synthetic compound):, Symptoms addressed by noopept:, Poor cognitive performance and memory, Reduced learning capacity.