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L-Histidine

Essential amino acid crucial for histamine production, metal chelation, and tissue repair

Scientific nameL-Histidine FormulaC6H9N3O2 Molecular weight155.15 g/mol CAS71-00-1
85 absorption score
7 safety / 10
25 USD per month
5 documented interactions

Check it against something

Evidence level B

L-Histidine with:

Compatibility score 78 out of 100
78 out of 100
Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Enhanced wound healing and tissue repair

Supports faster healing and tissue regeneration

Essential for collagen synthesis and tissue formation Evidence B-grade 1-6 weeks

Improved immune system function

Supports immune response and histamine regulation

Precursor to histamine and essential for immune cell function Evidence B-grade 2-4 weeks

Metal chelation and detoxification

Helps remove heavy metals and supports detox processes

Imidazole ring binds and chelates metal ions Evidence B-grade 2-8 weeks

Hemoglobin and red blood cell support

Important for healthy blood formation and oxygen transport

Essential component of hemoglobin and myoglobin Evidence A-grade 4-8 weeks

Growth and development support

Critical for proper growth in children and tissue maintenance

Essential for protein synthesis and cellular growth Evidence A-grade Ongoing

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Probiotics for Autoimmune Disease Support Gut health & immune modulation 10-100 billion CFU daily B 60% Vitamin D3 Bone health & immune support 1000-2000 IU A 85% Zinc Picolinate Superior immune & healing support 15-30 mg A 95% L-Lysine Immune support & collagen synthesis 1-3g A 90% Oregano Oil Powerful respiratory antimicrobial 100-300mg B 85% Oregano Oil for Antimicrobial Protection Antimicrobial & pathogen defense 1-3 drops diluted daily B 75%

Every pair we checked

12 combinations scored by the engine
L-Histidine + Copper Bisglycinate High copper may compete with histidine chelation Needs attention 58
L-Histidine + Caffeine No documented interaction either way No known interaction 70
L-Histidine + Creatine Monohydrate No documented interaction either way No known interaction 70
L-Histidine + Calcium Carbonate No documented interaction either way No known interaction 70
L-Histidine + Whey Protein No documented interaction either way No known interaction 70
L-Histidine + Lactase No documented interaction either way No known interaction 70
L-Histidine + Bovine Collagen No documented interaction either way No known interaction 70
L-Histidine + DHA No documented interaction either way No known interaction 70
L-Histidine + Turmeric No documented interaction either way No known interaction 70
L-Histidine + Vitamin D3 Both support collagen synthesis and wound healing Works better together 78
L-Histidine + Zinc Gluconate Both support immune function and wound healing Works better together 78
L-Histidine + Iron Sulfate Both important for hemoglobin formation Works better together 82

Dosage

With food
Daily500-2000mg
Maintenance200-500mg daily
Wound healing500-2000mg daily
Detoxification1-3g daily
Growth supportAge and weight dependent

Before you take it

VeganYes

When to expect it

First Effects1-2 weeks for wound healing and immune benefits
Peak Benefits4-8 weeks for sustained tissue and blood health benefits
Deficiency DevelopmentWeeks to months with inadequate protein intake
Toxicity OnsetRare, mainly histamine-related issues

How to measure it

$80-150
MarkerPlasma histidine levels or histamine metabolites
Optimal70-120 μmol/L
Deficient below<50 μmol/L
FrequencyOnly if monitoring growth, healing, or histamine issues

What people actually reported to the FDA

CAERS, 0 reports naming it as the suspect
Named as the suspect 0 reports of 1 that mention it at all

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not
Absorption Very high 85 of 100 · best absorbed form of this compound
Delivered daily 1062.5 mg
Cost per 100 mg delivered $0.08 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented
+
Vitamin C

Both support collagen synthesis and wound healing

Complementary roles in tissue formation and immune function · level B
+
Zinc

Both support immune function and wound healing

Complementary roles in tissue repair and immune response · level B
+
Iron

Both important for hemoglobin formation

Synergistic effects on red blood cell production · level A

What not to take with L-Histidine

2 documented
!
Copper Excess

High copper may compete with histidine chelation

Competition for metal binding sites · mild significance
!
Histamine Rich Foods

May exacerbate histamine intolerance

Additive histamine load · moderate for sensitive individuals significance

Medication interactions

Discuss these with a pharmacist before combining
antihistamines Minor

May counteract antihistamine effects

What to do: Monitor for reduced drug effectiveness

chelation-therapy Minor

May enhance metal chelation effects

What to do: May be beneficial for detoxification

Available forms

bioavailability compared
L-Histidine (Free Form) 85

L-Histidine (Free Form): Wound healing, Metal chelation, Immune support, Essential for growth

Food sources

before you supplement
Meat and poultry 0.6-1.0g per 100g · 85
Fish and seafood 0.5-0.8g per 100g · 85
Dairy products 0.3-0.6g per 100g · 80
Whole grains 0.2-0.4g per 100g · 70

Too little

deficiency signs
  • Slow wound healing and poor tissue repair
  • Anemia and reduced red blood cell production
  • Growth retardation in children
  • Impaired immune function
  • Skin rashes and dermatitis
  • Fatigue and weakness
  • Poor stress tolerance

Too much

toxicity signs
  • Rare with oral supplementation:
  • Histamine intolerance symptoms
  • Digestive upset and nausea
  • Potential mood changes
  • Generally good safety profile

Who benefits most

wound-healing-recovery

Supports faster tissue repair and healing processes

500-2000mg daily
immune-support

Important for immune function and histamine regulation

500-1500mg daily
heavy-metal-detox

Helps chelate and remove heavy metals from body

1-3g daily
anemia-blood-health

Essential for hemoglobin synthesis and red blood cell formation

500-1500mg daily
growth-development

Critical for proper growth in children and adolescents

Age-appropriate dosing

Where to buy it

compare forms first

Look for L-Histidine at 500-2000mg per serving. The form that matters here is L-Histidine (Free Form).

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What else affects it

Beyond other supplements
!
Histamine rich foods

May exacerbate histamine intolerance

Additive histamine load

How it works

  • Essential for collagen synthesis and tissue formation
  • Precursor to histamine for immune and allergic responses
  • Metal chelation through imidazole ring structure
  • Essential component of hemoglobin and myoglobin
  • Important for enzyme function and protein structure
  • Involved in pH buffering and acid-base balance

Key findings

what the evidence supports
  • Essential for children's growth and development
  • Important for wound healing and tissue repair
  • Effective for metal chelation and detoxification
  • Critical for hemoglobin formation and blood health

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of L-Histidine?

Documented effects: Enhanced wound healing and tissue repair; Improved immune system function; Metal chelation and detoxification; Hemoglobin and red blood cell support. Supports faster healing and tissue regeneration

How much L-Histidine should you take per day?

The common daily range is 500-2000mg. By goal — maintenance: 200-500mg daily; wound healing: 500-2000mg daily; detoxification: 1-3g daily; growth support: Age and weight dependent.

When is the best time to take L-Histidine?

With food. First effects are typically reported within 1-2 weeks for wound healing and immune benefits.

What are the side effects of L-Histidine?

At excessive doses: Rare with oral supplementation:, Histamine intolerance symptoms, Digestive upset and nausea, Potential mood changes, Generally good safety profile. Safety rating at normal doses is 7 out of 10.

What should you not take with L-Histidine?

Separate it from Copper Excess, Histamine Rich Foods by two to four hours. High copper may compete with histidine chelation

Does L-Histidine interact with medications?

Documented interactions with antihistamines, chelation-therapy. Discuss these with a pharmacist before combining.

How do you know if you need L-Histidine?

The marker is Plasma histidine levels or histamine metabolites, optimal range 70-120 μmol/L. Common deficiency signs: Slow wound healing and poor tissue repair, Anemia and reduced red blood cell production, Growth retardation in children, Impaired immune function.

Taken for

59 Immunity

Vitamin D3 · Vitamin C (Ascorbic Acid) · Comprehensive Immune Support Complex