Bone resorption inhibition
Effectively inhibits bone breakdown and resorption processes
Ipriflavone
Synthetic isoflavone derivative that supports bone health by inhibiting bone resorption and promoting bone formation, particularly beneficial for postmenopausal bone health
Scientific name7-Isopropoxyisoflavone
FormulaC18H16O3
Molecular weight280.32 g/mol
CAS35212-22-7
90
absorption score
7
safety / 10
60
USD per month
5
documented interactions
Check it against something
Ipriflavone with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
83
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimPostmenopausal bone health support
Specifically supports bone health during and after menopause
Bone density maintenance
Helps maintain bone mineral density and prevent bone loss
Enhanced calcium utilization
Improves calcium metabolism and bone incorporation
Osteoporosis prevention support
Provides preventive support against osteoporosis development
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Calcium
Bone health & muscle function
1,000-1,200 mg
A
30%
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Vitamin D3
Bone health & immune support
1000-2000 IU
A
85%
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Calcium Carbonate
Affordable bone health & antacid
1000-1200 mg
A
25%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Every pair we checked
12 combinations scored by the engine
Ipriflavone + Caffeine
High caffeine may counteract bone protective effects
Needs attention
58
Ipriflavone + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Ipriflavone + Whey Protein
No documented interaction either way
No known interaction
70
Ipriflavone + Lactase
No documented interaction either way
No known interaction
70
Ipriflavone + Bovine Collagen
No documented interaction either way
No known interaction
70
Ipriflavone + DHA
No documented interaction either way
No known interaction
70
Ipriflavone + Turmeric
No documented interaction either way
No known interaction
70
Ipriflavone + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Ipriflavone + Calcium Carbonate
Enhanced bone health and mineral utilization
Works better together
78
Ipriflavone + Magnesium Oxide
Enhanced bone health and mineral utilization
Works better together
78
Ipriflavone + Vitamin D3
Synergistic bone health and absorption benefits
Works better together
83
Ipriflavone + Vitamin C (Ascorbic Acid)
Synergistic bone health and absorption benefits
Works better together
83
Dosage
Daily400-600mg
Bone health support400-600mg daily
Postmenopausal support600mg daily
Osteoporosis prevention600mg daily
Calcium enhancement400mg daily
When to expect it
First Effects4-8 weeks for initial bone resorption marker improvements
Peak Benefits12-24 weeks for sustained bone health and density benefits
Deficiency DevelopmentNot applicable - ipriflavone is not an essential nutrient
Toxicity OnsetRare with proper dosing and monitoring
How to measure it
MarkerBone turnover markers, lymphocyte count, kidney function, bone density
OptimalReduced bone resorption markers, normal immune and kidney function
Deficient belowHigh bone resorption, declining bone density
FrequencyEvery 3-6 months for safety monitoring and bone health assessment
What people actually reported to the FDA
CAERS, 1 reports naming it as the suspectMost reported effects
Named as the suspect
1 reports
of 1 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event1
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 90 of 100 · best absorbed form of this compound
Delivered daily
450 mg
Cost per 100 mg delivered
$0.44 comparative — uses the absorption score, not a measured percentage
Works better with
+
Calcium Magnesium
Enhanced bone health and mineral utilization
Ipriflavone enhances calcium effectiveness and bone incorporation · level B
+
Vitamin D3
Synergistic bone health and absorption benefits
Vitamin D supports calcium absorption that ipriflavone optimizes · level B
+
Vitamin K2
Comprehensive bone health through complementary mechanisms
K2 directs calcium while ipriflavone inhibits bone breakdown · level CWhat not to take with Ipriflavone
!
Excessive Caffeine
High caffeine may counteract bone protective effects
Caffeine increases calcium excretion reducing bone benefits · mild significance
!
Smoking
Smoking reduces ipriflavone effectiveness for bone health
Smoking impairs bone formation and healing processes · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay interact with immune system medications
What to do: Monitor immune function and lymphocyte counts
May have additive bone health effects
What to do: Medical supervision for combination therapy
Available forms
Ipriflavone (Synthetic Isoflavone): Proven bone benefits, Non-hormonal, Research-backed, Targeted action
Food sources
Not naturally occurring
Synthetic compound only
Natural isoflavones (soy)
Different compounds with weaker effects · 30
Ipriflavone supplements
400-600mg per dose · 90
Bone health formulas
Combined with other bone nutrients · 85
Too little
- No specific ipriflavone deficiency as it's not essential:
- Missing bone resorption inhibition benefits
- Reduced bone protection during menopause
- Suboptimal calcium utilization efficiency
- Higher bone loss rates without support
- Increased osteoporosis risk factors
Too much
- Generally well tolerated with monitoring:
- Potential lymphocyte count reduction
- Possible kidney function changes
- Gastrointestinal upset in some individuals
- Regular monitoring recommended for long-term use
Who benefits most
postmenopausal-women
Bone health support during menopause and post-menopause
600mg daily (200mg three times daily)
osteoporosis-prevention
Prevention of osteoporosis and bone density loss
600mg daily
bone-resorption-concerns
Support for individuals with elevated bone resorption markers
600mg daily
hormone-therapy-alternative
Non-hormonal bone support for those avoiding hormone therapy
600mg daily
calcium-supplement-users
Enhanced effectiveness of calcium and vitamin D supplementation
400-600mg dailyWhere to buy it
Look for Ipriflavone at 400-600mg per serving. The form that matters here is Ipriflavone (Synthetic Isoflavone).
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What else affects it
Beyond other supplements
!
Excessive caffeine
High caffeine may counteract bone protective effects
Caffeine increases calcium excretion reducing bone benefits
!
Smoking
Smoking reduces ipriflavone effectiveness for bone health
Smoking impairs bone formation and healing processesHow it works
- Directly inhibits osteoclast activity and bone resorption processes
- Stimulates osteoblast proliferation and bone formation activity
- Enhances calcium absorption and utilization in bone tissue
- Modulates bone remodeling balance favoring bone formation
- Provides bone protective effects without estrogenic activity
- Supports collagen synthesis and bone matrix formation
Key findings
what the evidence supports- Good evidence for bone resorption inhibition and density maintenance
- Moderate research on postmenopausal bone health benefits
- Important safety considerations require monitoring
- Most effective when combined with calcium and vitamin D
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Ipriflavone?
Documented effects: Bone resorption inhibition; Postmenopausal bone health support; Bone density maintenance; Enhanced calcium utilization. Effectively inhibits bone breakdown and resorption processes
How much Ipriflavone should you take per day?
The common daily range is 400-600mg. By goal — bone health support: 400-600mg daily; postmenopausal support: 600mg daily; osteoporosis prevention: 600mg daily; calcium enhancement: 400mg daily.
When is the best time to take Ipriflavone?
With meals divided. First effects are typically reported within 4-8 weeks for initial bone resorption marker improvements.
What are the side effects of Ipriflavone?
At excessive doses: Generally well tolerated with monitoring:, Potential lymphocyte count reduction, Possible kidney function changes, Gastrointestinal upset in some individuals, Regular monitoring recommended for long-term use. Safety rating at normal doses is 7 out of 10.
What should you not take with Ipriflavone?
Separate it from Excessive Caffeine, Smoking by two to four hours. High caffeine may counteract bone protective effects
Does Ipriflavone interact with medications?
Documented interactions with immunosuppressants, osteoporosis-medications. Discuss these with a pharmacist before combining.
How do you know if you need Ipriflavone?
The marker is Bone turnover markers, lymphocyte count, kidney function, bone density, optimal range Reduced bone resorption markers, normal immune and kidney function. Common deficiency signs: No specific ipriflavone deficiency as it's not essential:, Missing bone resorption inhibition benefits, Reduced bone protection during menopause, Suboptimal calcium utilization efficiency.