Agmatine Sulfate

Arginine metabolite that enhances nitric oxide while inhibiting arginase, providing sustained pumps and potential cognitive benefits

Scientific name4-Aminobutyl guanidine sulfate FormulaC5H14N4·H2SO4 Molecular weight228.27 g/mol CAS2482-00-0

80 absorption score

6 safety / 10

45 USD per month

5 documented interactions

Check it against something

Evidence level C

Agmatine Sulfate with:

75 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Enhanced and sustained muscle pumps

Provides longer-lasting and more intense muscle pumps than arginine

Inhibits arginase enzyme while supporting nitric oxide production Evidence C-grade 30-180 minutes

Improved nitric oxide regulation

Optimizes nitric oxide production through multiple pathways

Modulates nitric oxide synthase and inhibits arginine breakdown Evidence C-grade 45-240 minutes

Enhanced focus and cognitive function

May improve mental focus and cognitive performance

Modulates neurotransmitter systems and NMDA receptors Evidence C-grade 30-120 minutes

Potential pain reduction and recovery

May help reduce exercise-induced pain and improve recovery

Modulates pain pathways and inflammatory responses Evidence C-grade 1-6 hours

Insulin sensitivity support

May help improve insulin sensitivity and glucose uptake

Enhances cellular glucose uptake and insulin signaling Evidence C-grade 1-4 hours

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Creatine Monohydrate Strength & power enhancement 3-5g A 95% Calcium Bone health & muscle function 1,000-1,200 mg A 30% Magnesium Glycinate Superior absorption sleep & muscle support 200-600 mg A 90% Whey Protein Muscle growth & recovery 25-75g A 95% Creatine HCL Enhanced muscle building 1.5-3g B 98% Oregano Oil Powerful respiratory antimicrobial 100-300mg B 85%

Every pair we checked

12 combinations scored by the engine

Agmatine Sulfate + Caffeine No documented interaction either way No known interaction 70

Agmatine Sulfate + Creatine Monohydrate No documented interaction either way No known interaction 70

Agmatine Sulfate + Vitamin D3 No documented interaction either way No known interaction 70

Agmatine Sulfate + Calcium Carbonate No documented interaction either way No known interaction 70

Agmatine Sulfate + Whey Protein No documented interaction either way No known interaction 70

Agmatine Sulfate + Lactase No documented interaction either way No known interaction 70

Agmatine Sulfate + Bovine Collagen No documented interaction either way No known interaction 70

Agmatine Sulfate + DHA No documented interaction either way No known interaction 70

Agmatine Sulfate + Turmeric No documented interaction either way No known interaction 70

Agmatine Sulfate + L-Citrulline Enhanced nitric oxide production through complementary mechanisms Works better together 75

Agmatine Sulfate + Beetroot Powder Enhanced nitric oxide through different pathways Works better together 75

Agmatine Sulfate + Taurine May enhance cellular function and pumps Works better together 75

Dosage

Empty stomach pre workout

Daily500-1500mg

Pump enhancement500-1000mg pre-workout empty stomach

Cognitive support250-750mg twice daily

Insulin sensitivity500-1000mg with meals

Pain management1000-1500mg daily divided doses

When to expect it

First Effects30-60 minutes for initial pump and focus benefits

Peak Benefits60-240 minutes for maximum vasodilation and cognitive effects

Deficiency DevelopmentNot applicable - endogenously produced compound

Toxicity OnsetUnknown - limited long-term human data

How to measure it

$300-500

MarkerNot routinely measured - research only

OptimalNo established clinical ranges

Deficient belowNot applicable - not essential nutrient

FrequencyResearch purposes only - monitor subjective effects

What people actually reported to the FDA

CAERS, 2 reports naming it as the suspect

Most reported effects

Acute myocardial infarction 1

Abdominal discomfort 1

Depressed mood 1

Depression 1

Named as the suspect 2 reports of 4 that mention it at all

Serious outcome 100% hospitalisation, emergency room or worse

Life Threatening1

Hospitalization1

Other Serious or Important Medical Event1

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption Very high 80 of 100 · best absorbed form of this compound

Delivered daily 800 mg

Cost per 100 mg delivered $0.19 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Citrulline

Enhanced nitric oxide production through complementary mechanisms

Citrulline provides arginine while agmatine prevents its breakdown · level C

Beetroot Nitrates

Enhanced nitric oxide through different pathways

Multiple NO production pathways working synergistically · level C

Taurine

May enhance cellular function and pumps

Both affect cellular osmolality and function · level C

What not to take with Agmatine Sulfate

2 documented

High Protein Meals

Large protein meals may compete with agmatine absorption

Competition for amino acid transporters · minor significance

Arginase Enhancers

Compounds that increase arginase may oppose agmatine effects

Counteracts agmatine's arginase inhibition · theoretical significance

Medication interactions

Discuss these with a pharmacist before combining

psychiatric-medications Unknown

May interact with drugs affecting neurotransmitter systems

What to do: Consult healthcare provider before use

blood-pressure-medications Minor

May enhance hypotensive effects

What to do: Monitor blood pressure with concurrent use

diabetes-medications Minor

May enhance blood sugar lowering effects

What to do: Monitor blood glucose levels

Available forms

bioavailability compared

Agmatine Sulfate (Pure) 80

Agmatine Sulfate (Pure): Sustained pumps, Unique mechanism, Multiple benefits, Lower doses needed

Food sources

before you supplement

Fermented foods Small amounts from bacterial production · 60

Fish and seafood Trace amounts naturally occurring · 60

Not significant in regular diet Supplementation required for therapeutic doses · N/A

Agmatine sulfate supplements 250-1000mg per serving · 80

Too little

deficiency signs

Not applicable (endogenously produced compound):
Potential benefits addressed by agmatine:
Suboptimal muscle pumps and vasodilation
Poor nitric oxide regulation
Reduced cognitive performance
Higher exercise-induced pain
Impaired insulin sensitivity

Too much

toxicity signs

Limited data on toxicity - generally well tolerated:
Potential gastrointestinal upset
Unknown long-term effects
Possible interactions with medications
Individual sensitivity variations

Who benefits most

advanced-pump-seekers

Provides enhanced and sustained muscle pumps beyond basic NO boosters

500-1000mg pre-workout on empty stomach

cognitive-enhancement-athletes

May provide dual benefits of pumps and mental focus

750-1500mg daily divided doses

insulin-sensitivity-seekers

May help improve glucose uptake and metabolic function

500-1000mg with meals

pain-management-athletes

May help reduce exercise-induced pain and discomfort

1000-1500mg daily divided doses

supplement-experimenters

For those seeking cutting-edge supplements with unique mechanisms

500-1500mg daily as tolerated

Where to buy it

compare forms first

Look for Agmatine Sulfate at 500-1500mg per serving. The form that matters here is Agmatine Sulfate (Pure).

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What else affects it

Beyond other supplements

High protein meals

Large protein meals may compete with agmatine absorption

Competition for amino acid transporters

How it works

Inhibits arginase enzyme preventing arginine breakdown
Modulates nitric oxide synthase activity
Acts as NMDA receptor antagonist affecting cognition
Modulates neurotransmitter systems including serotonin and norepinephrine
Enhances insulin sensitivity and glucose uptake
Provides neuroprotective effects through multiple pathways

Key findings

what the evidence supports

Promising but limited human research on pump and cognitive benefits
More potent than arginine for nitric oxide enhancement
Unique mechanism through arginase inhibition
Safety profile not fully established in humans

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Agmatine Sulfate?

Documented effects: Enhanced and sustained muscle pumps; Improved nitric oxide regulation; Enhanced focus and cognitive function; Potential pain reduction and recovery. Provides longer-lasting and more intense muscle pumps than arginine

How much Agmatine Sulfate should you take per day?

The common daily range is 500-1500mg. By goal — pump enhancement: 500-1000mg pre-workout empty stomach; cognitive support: 250-750mg twice daily; insulin sensitivity: 500-1000mg with meals; pain management: 1000-1500mg daily divided doses.

When is the best time to take Agmatine Sulfate?

Empty stomach pre workout. First effects are typically reported within 30-60 minutes for initial pump and focus benefits.

What are the side effects of Agmatine Sulfate?

At excessive doses: Limited data on toxicity - generally well tolerated:, Potential gastrointestinal upset, Unknown long-term effects, Possible interactions with medications, Individual sensitivity variations. Safety rating at normal doses is 6 out of 10.

What should you not take with Agmatine Sulfate?

Separate it from High Protein Meals, Arginase Enhancers by two to four hours. Large protein meals may compete with agmatine absorption

Does Agmatine Sulfate interact with medications?

Documented interactions with psychiatric-medications, blood-pressure-medications, diabetes-medications. Discuss these with a pharmacist before combining.

How do you know if you need Agmatine Sulfate?

The marker is Not routinely measured - research only, optimal range No established clinical ranges. Common deficiency signs: Not applicable (endogenously produced compound):, Potential benefits addressed by agmatine:, Suboptimal muscle pumps and vasodilation, Poor nitric oxide regulation.

Taken for

43 Performance

Caffeine · Creatine Monohydrate · Whey Protein