Bone health and mineralization support
Essential for proper bone formation and mineralization
Silicon
Trace mineral essential for connective tissue formation, bone health, and skin integrity, playing important roles in collagen synthesis and tissue strength
Scientific nameSilicon
FormulaSi
Molecular weight28.09 g/mol
CAS7440-21-3
40
absorption score
8
safety / 10
25
USD per month
5
documented interactions
Check it against something
Silicon with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
82
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimConnective tissue and collagen synthesis
Supports healthy connective tissue formation and collagen production
Skin health and elasticity
Supports skin health, elasticity, and anti-aging properties
Hair and nail strength
Supports healthy hair growth and nail strength
Joint health and cartilage support
Supports joint health and cartilage maintenance
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Calcium
Bone health & muscle function
1,000-1,200 mg
A
30%
Turmeric
Anti-inflammatory & antioxidant
300-1000mg
A
3%
Vitamin D3
Bone health & immune support
1000-2000 IU
A
85%
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Calcium Carbonate
Affordable bone health & antacid
1000-1200 mg
A
25%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Every pair we checked
12 combinations scored by the engine
Silicon + Caffeine
No documented interaction either way
No known interaction
70
Silicon + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Silicon + Whey Protein
No documented interaction either way
No known interaction
70
Silicon + Lactase
No documented interaction either way
No known interaction
70
Silicon + Bovine Collagen
No documented interaction either way
No known interaction
70
Silicon + DHA
No documented interaction either way
No known interaction
70
Silicon + Turmeric
No documented interaction either way
No known interaction
70
Silicon + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Silicon + Marine Collagen
No documented interaction either way
No known interaction
70
Silicon + Calcium Carbonate
Enhanced bone health and mineralization
Works better together
78
Silicon + Magnesium Oxide
Improved bone health and connective tissue support
Works better together
78
Silicon + Vitamin D3
Enhanced collagen synthesis and connective tissue formation
Works better together
82
Dosage
Daily5-40mg
Bone health support5-40mg daily
Skin anti aging5-20mg daily
Hair nail health5-20mg daily
Joint support5-40mg daily
Before you take it
VeganYes
When to expect it
First Effects6-12 weeks for initial connective tissue and skin improvements
Peak Benefits16-24 weeks for sustained bone health and structural benefits
Deficiency DevelopmentMay occur with poor diet and aging
Toxicity OnsetVery rare with normal supplementation doses
How to measure it
MarkerSerum silicon, bone formation markers, collagen synthesis markers
OptimalAdequate silicon levels, normal bone turnover markers
Deficient belowLow silicon levels, poor collagen markers
FrequencyEvery 6-12 months for bone and connective tissue assessment
What people actually reported to the FDA
CAERS, 1 reports naming it as the suspectMost reported effects
Named as the suspect
1 reports
of 2 that mention it at all
Serious outcome
100%
hospitalisation, emergency room or worse
Hospitalization1
Other Serious or Important Medical Event1
Visited Emergency Room1
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Moderate 40 of 100 · middle of the range for this compound
Delivered daily
9 mg
Cost per 100 mg delivered
$9.26 comparative — uses the absorption score, not a measured percentage
Works better with
+
Vitamin C
Enhanced collagen synthesis and connective tissue formation
Both essential for collagen hydroxylation and cross-linking · level A
+
Calcium
Enhanced bone health and mineralization
Silicon improves calcium utilization and bone matrix formation · level B
+
Magnesium
Improved bone health and connective tissue support
Both minerals support bone formation and tissue integrity · level BWhat not to take with Silicon
!
Aluminum
Aluminum may interfere with silicon absorption and function
Chemical interaction affecting silicon bioavailability · mild significance
!
Excessive Phosphorus
High phosphorus may interfere with silicon utilization
Phosphorus-silicon interaction affecting bone metabolism · mild significanceMedication interactions
Discuss these with a pharmacist before combiningMay affect silicon excretion and levels
What to do: Monitor if on long-term diuretic therapy
May complement bone-building medication effects
What to do: Generally compatible with bone medications
Available forms
Choline-Stabilized Orthosilicic Acid (Highest Bioavailability): Bone health support, Connective tissue benefits, Skin/hair/nail health, Well absorbed
Food sources
Bamboo extract
High bioavailable silicon content · 50
Whole grains and cereals
2-10mg per 100g · 20
Bananas
4-5mg per medium banana · 25
Silicon supplements
5-40mg per dose · 40
Too little
- Silicon deficiency symptoms:
- Poor bone formation and increased fracture risk
- Weak connective tissues and poor wound healing
- Brittle hair and weak nails
- Reduced skin elasticity and premature aging
- Joint problems and cartilage degeneration
- Cardiovascular tissue weakness
Too much
- Silicon excess symptoms (very rare):
- Respiratory irritation if crystalline silica inhaled
- Potential kidney stone formation with extreme doses
- Generally very safe with normal supplementation
- Amorphous silica forms are considered safe
Who benefits most
bone-health-support
Bone formation and mineralization enhancement
5-40mg daily
skin-anti-aging
Skin health, elasticity, and anti-aging support
5-20mg daily
hair-nail-health
Hair growth and nail strength enhancement
5-20mg daily
joint-connective-tissue
Joint health and connective tissue support
5-40mg daily
aging-adults
Age-related tissue maintenance and structural support
5-20mg dailyWhere to buy it
Look for Silicon at 5-40mg per serving. The form that matters here is Choline-Stabilized Orthosilicic Acid (Highest Bioavailability).
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What else affects it
Beyond other supplements
!
Aluminum
Aluminum may interfere with silicon absorption and function
Chemical interaction affecting silicon bioavailability
!
Excessive phosphorus
High phosphorus may interfere with silicon utilization
Phosphorus-silicon interaction affecting bone metabolismHow it works
- Essential cofactor for prolyl 4-hydroxylase in collagen synthesis
- Required for proper cross-linking of collagen and elastin fibers
- Supports bone matrix formation and mineralization processes
- Maintains structural integrity of connective tissues
- Important for glycosaminoglycan synthesis in cartilage and skin
- Supports cellular hydration and tissue elasticity
Key findings
what the evidence supports- Good evidence for bone health and connective tissue support
- Moderate research on skin, hair, and nail benefits
- Essential for collagen synthesis and tissue integrity
- Generally safe with good tolerability profile
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Silicon?
Documented effects: Bone health and mineralization support; Connective tissue and collagen synthesis; Skin health and elasticity; Hair and nail strength. Essential for proper bone formation and mineralization
How much Silicon should you take per day?
The common daily range is 5-40mg. By goal — bone health support: 5-40mg daily; skin anti aging: 5-20mg daily; hair nail health: 5-20mg daily; joint support: 5-40mg daily.
When is the best time to take Silicon?
With meals. First effects are typically reported within 6-12 weeks for initial connective tissue and skin improvements.
What are the side effects of Silicon?
At excessive doses: Silicon excess symptoms (very rare):, Respiratory irritation if crystalline silica inhaled, Potential kidney stone formation with extreme doses, Generally very safe with normal supplementation, Amorphous silica forms are considered safe. Safety rating at normal doses is 8 out of 10.
What should you not take with Silicon?
Separate it from Aluminum, Excessive Phosphorus by two to four hours. Aluminum may interfere with silicon absorption and function
Does Silicon interact with medications?
Documented interactions with diuretics, bone-medications. Discuss these with a pharmacist before combining.
How do you know if you need Silicon?
The marker is Serum silicon, bone formation markers, collagen synthesis markers, optimal range Adequate silicon levels, normal bone turnover markers. Common deficiency signs: Silicon deficiency symptoms:, Poor bone formation and increased fracture risk, Weak connective tissues and poor wound healing, Brittle hair and weak nails.