Enhanced memory and learning
Improves memory formation, recall, and learning capacity
Phosphatidylserine
Essential phospholipid that supports brain cell membrane function, memory, cognitive performance, and stress management
Scientific namePhosphatidyl-L-serine
FormulaC13H24NO10P
Molecular weight385.3 g/mol
CAS51446-62-9
85
absorption score
9
safety / 10
45
USD per month
5
documented interactions
Check it against something
Phosphatidylserine with:
- Acetyl-L-Carnitine
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
86
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimImproved cognitive performance
Enhances attention, processing speed, and mental clarity
Stress and cortisol management
Reduces cortisol levels and improves stress response
Age-related cognitive decline prevention
May slow cognitive aging and support brain health
Athletic performance and recovery
May improve exercise performance and reduce exercise-induced stress
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
L-Theanine
Calm focus & stress relief
100-400mg
B
90%
Vitamin B8 (Inositol)
Mental health & PCOS support
2-18g (condition dependent)
B
95%
SAM-e
Mood support & liver health
400-800mg
A
70%
Lithium Orotate
Mood & brain support
1-20mg
C
60%
Every pair we checked
12 combinations scored by the engine
Phosphatidylserine + Caffeine
No documented interaction either way
No known interaction
70
Phosphatidylserine + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Phosphatidylserine + Vitamin D3
No documented interaction either way
No known interaction
70
Phosphatidylserine + Calcium Carbonate
No documented interaction either way
No known interaction
70
Phosphatidylserine + Whey Protein
No documented interaction either way
No known interaction
70
Phosphatidylserine + Lactase
No documented interaction either way
No known interaction
70
Phosphatidylserine + Bovine Collagen
No documented interaction either way
No known interaction
70
Phosphatidylserine + Turmeric
No documented interaction either way
No known interaction
70
Phosphatidylserine + Ginkgo Biloba
Enhanced cognitive function and circulation
Works better together
78
Phosphatidylserine + DHA
Enhanced cognitive function and memory support
Works better together
78
Phosphatidylserine + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced brain membrane function and neuroprotection
Works better together
82
Phosphatidylserine + Acetyl-L-Carnitine
Enhanced cognitive function and memory
Works better together
86
Dosage
Daily100-300mg
Memory enhancement100-300mg daily
Cognitive support100-200mg daily
Stress management200-400mg daily
Athletic performance200-400mg daily
When to expect it
First Effects2-4 weeks for stress management and initial cognitive benefits
Peak Benefits8-16 weeks for sustained memory and cognitive improvements
Deficiency DevelopmentGradual decline in memory and cognitive function
Toxicity OnsetVery rare, excellent safety profile
How to measure it
MarkerCortisol levels or cognitive function assessments
OptimalBalanced cortisol rhythm and improved cognitive markers
Deficient belowNot routinely measured
FrequencyEvery 6-12 months for stress and cognitive monitoring
What people actually reported to the FDA
CAERS, 20 reports naming it as the suspectMost reported effects
Named as the suspect
20 reports
of 22 that mention it at all
Serious outcome
92%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event13
Hospitalization9
Life Threatening6
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
Very high 85 of 100 · best absorbed form of this compound
Delivered daily
170 mg
Cost per 100 mg delivered
$0.88 comparative — uses the absorption score, not a measured percentage
Works better with
+
Omega 3 Fatty Acids
Enhanced brain membrane function and neuroprotection
Both support brain cell membrane structure and function · level A
+
Acetyl L Carnitine
Enhanced cognitive function and memory
Complementary effects on brain energy and neurotransmitters · level B
+
Ginkgo Biloba
Enhanced cognitive function and circulation
Both support brain function through different pathways · level BWhat not to take with Phosphatidylserine
!
Chronic Stress
Chronic stress depletes PS and impairs brain function
Stress hormones damage brain cell membranes · major significance
!
Alcohol Excess
Alcohol damages brain cell membranes
Ethanol disrupts phospholipid membrane integrity · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay have mild anticoagulant effects
What to do: Monitor bleeding parameters
May enhance effects of Alzheimer's medications
What to do: May improve drug effectiveness
Generally no significant drug interactions
What to do: Safe with most medications
Available forms
Phosphatidylserine (Soy-derived): Memory enhancement, Stress reduction, FDA health claim, Excellent safety
Phosphatidylserine (Sunflower-derived): Non-soy source, Better tolerance, Higher purity, Allergen-free
Food sources
Organ meats (brain, liver)
Highest natural sources · 75
Fish (mackerel, herring)
Good dietary sources · 70
Soybeans and soy lecithin
Moderate amounts · 65
PS supplements
100-300mg per capsule · 85-90
Too little
- Memory problems and forgetfulness
- Poor concentration and mental fatigue
- Increased stress sensitivity and high cortisol
- Age-related cognitive decline
- Difficulty learning new information
- Poor stress recovery and adaptation
- Reduced mental clarity and processing speed
Too much
- Excellent safety profile:
- Mild stomach upset with high doses
- Rare sleep disturbances if taken late
- Very rare allergic reactions
- Generally very well tolerated
Who benefits most
memory-cognitive-decline
Excellent for improving memory and preventing cognitive decline
100-300mg daily
aging-adults-brain-health
Supports brain health and may slow cognitive aging
100-300mg daily
stress-management-cortisol
Effective for reducing stress and cortisol levels
200-400mg daily
students-cognitive-performance
Enhances learning, memory, and mental performance
100-200mg daily
athletes-stress-recovery
May improve performance and reduce exercise-induced stress
200-400mg dailyWhere to buy it
Look for Phosphatidylserine at 100-300mg per serving. The form that matters here is Phosphatidylserine (Soy-derived).
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What else affects it
Beyond other supplements
!
Chronic stress
Chronic stress depletes PS and impairs brain function
Stress hormones damage brain cell membranes
!
Alcohol excess
Alcohol damages brain cell membranes
Ethanol disrupts phospholipid membrane integrityHow it works
- Maintains brain cell membrane fluidity and integrity
- Essential for neurotransmitter synthesis and release
- Supports acetylcholine production for memory function
- Modulates stress response and reduces cortisol levels
- Promotes nerve growth factor and brain-derived neurotrophic factor
- Facilitates glucose uptake and energy metabolism in brain cells
Key findings
what the evidence supports- Strong evidence for memory enhancement and cognitive support
- Effective for stress management and cortisol reduction
- FDA qualified health claim for cognitive dysfunction
- Excellent safety profile with minimal side effects
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Phosphatidylserine?
Documented effects: Enhanced memory and learning; Improved cognitive performance; Stress and cortisol management; Age-related cognitive decline prevention. Improves memory formation, recall, and learning capacity
How much Phosphatidylserine should you take per day?
The common daily range is 100-300mg. By goal — memory enhancement: 100-300mg daily; cognitive support: 100-200mg daily; stress management: 200-400mg daily; athletic performance: 200-400mg daily.
When is the best time to take Phosphatidylserine?
With meals. First effects are typically reported within 2-4 weeks for stress management and initial cognitive benefits.
What are the side effects of Phosphatidylserine?
At excessive doses: Excellent safety profile:, Mild stomach upset with high doses, Rare sleep disturbances if taken late, Very rare allergic reactions, Generally very well tolerated. Safety rating at normal doses is 9 out of 10.
What should you not take with Phosphatidylserine?
Separate it from Chronic Stress, Alcohol Excess by two to four hours. Chronic stress depletes PS and impairs brain function
Does Phosphatidylserine interact with medications?
Documented interactions with blood-thinners, cholinesterase-inhibitors, no-significant-interactions. Discuss these with a pharmacist before combining.
How do you know if you need Phosphatidylserine?
The marker is Cortisol levels or cognitive function assessments, optimal range Balanced cortisol rhythm and improved cognitive markers. Common deficiency signs: Memory problems and forgetfulness, Poor concentration and mental fatigue, Increased stress sensitivity and high cortisol, Age-related cognitive decline.