Blood pressure reduction
Helps reduce both systolic and diastolic blood pressure naturally
Olive Leaf Extract
Mediterranean olive leaf extract rich in oleuropein, providing cardiovascular protection and immune support
Scientific nameOlea europaea
FormulaC25H32O13 (oleuropein)
Molecular weight540.51 g/mol
CAS32619-42-4
75
absorption score
8
safety / 10
35
USD per month
5
documented interactions
Check it against something
Olive Leaf Extract with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimPowerful cardiovascular antioxidant protection
Protects heart and blood vessels from oxidative damage
Cholesterol and lipid support
May help improve cholesterol levels and lipid profiles
Immune system enhancement
Supports immune function and may have antimicrobial properties
Anti-inflammatory effects
Reduces inflammation throughout the body
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Probiotics for Autoimmune Disease Support
Gut health & immune modulation
10-100 billion CFU daily
B
60%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Vitamin D3
Bone health & immune support
1000-2000 IU
A
85%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
Psyllium Husk
Digestive health & cholesterol support
5-15g
A
95%
Zinc Picolinate
Superior immune & healing support
15-30 mg
A
95%
Every pair we checked
12 combinations scored by the engine
Olive Leaf Extract + Caffeine
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Calcium Carbonate
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Whey Protein
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Lactase
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Bovine Collagen
No documented interaction either way
No known interaction
70
Olive Leaf Extract + DHA
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Turmeric
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Olive Leaf Extract + Coenzyme Q10 (CoQ10)
Synergistic cardiovascular protection
Works better together
75
Olive Leaf Extract + Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
Enhanced cardiovascular and anti-inflammatory benefits
Works better together
75
Olive Leaf Extract + Vitamin D3
Enhanced antioxidant protection and immune support
Works better together
78
Dosage
Daily250-1000mg
Cardiovascular support500-1000mg daily
Blood pressure support500-1000mg daily
Immune support500-750mg daily
Antioxidant support250-500mg daily
Before you take it
VeganYes
When to expect it
First Effects2-4 weeks for cardiovascular and immune benefits
Peak Benefits6-12 weeks for sustained heart health and protection
Deficiency DevelopmentNot applicable - herbal supplement
Toxicity OnsetVery rare, mainly drug interactions
How to measure it
MarkerBlood pressure, antioxidant status, inflammatory markers
OptimalBP: <140/90 mmHg, low inflammatory markers
Deficient belowNot applicable for herbal supplement
FrequencyEvery 3-6 months if using for cardiovascular support
What people actually reported to the FDA
CAERS, 15 reports naming it as the suspectMost reported effects
Named as the suspect
15 reports
of 23 that mention it at all
Serious outcome
83%
hospitalisation, emergency room or worse
Hospitalization8
Other Serious or Important Medical Event7
Other Serious Outcome3
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Absorption
High 75 of 100 · absorbs well relative to other forms
Delivered daily
468.8 mg
Cost per 100 mg delivered
$0.25 comparative — uses the absorption score, not a measured percentage
Works better with
+
Vitamin C
Enhanced antioxidant protection and immune support
Complementary antioxidant systems work together · level B
+
Coq10
Synergistic cardiovascular protection
Complementary cardioprotective mechanisms · level C
+
Omega 3 Fatty Acids
Enhanced cardiovascular and anti-inflammatory benefits
Multiple pathways supporting heart health · level CWhat not to take with Olive Leaf Extract
!
High Sodium Diet
Excessive sodium may counteract blood pressure benefits
Sodium promotes hypertension that olive extract helps reduce · moderate significance
!
Processed Foods
High oxidative stress from processed foods may overwhelm antioxidant benefits
Counteracts antioxidant protection · mild significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance blood pressure lowering effects
What to do: Monitor blood pressure closely
May enhance blood sugar lowering effects
What to do: Monitor blood glucose levels
Antioxidants may interfere with some cancer treatments
What to do: Consult oncologist before use
Available forms
Olive Leaf Extract (20% Oleuropein): Mediterranean tradition, Cardiovascular benefits, Immune support, Rich antioxidants
Food sources
Fresh olive leaves
High oleuropein content · 60
Extra virgin olive oil
Some polyphenols but lower concentration · 50
Olive leaf tea
Moderate oleuropein content · 65
Standardized extracts
20% oleuropein concentration · 75
Too little
- Not applicable (herbal supplement, not essential nutrient):
- General symptoms addressed by olive leaf extract:
- High blood pressure and cardiovascular stress
- Poor antioxidant protection
- Compromised immune function
- Increased oxidative stress
- Vascular inflammation
Too much
- Generally very safe with minimal side effects:
- Blood pressure lowering effects
- Mild digestive upset
- Blood sugar effects
- Rare allergic reactions
Who benefits most
mild-hypertension
Natural support for healthy blood pressure levels
500-1000mg daily (20% oleuropein)
cardiovascular-prevention
Provides antioxidant protection and heart health support
250-500mg daily
immune-support
Enhances immune function and provides antimicrobial benefits
500-750mg daily
antioxidant-support
Rich source of polyphenolic antioxidants for overall protection
250-500mg daily
mediterranean-diet-followers
Complements Mediterranean diet principles for optimal health
250-500mg dailyWhere to buy it
Look for Olive Leaf Extract at 250-1000mg per serving. The form that matters here is Olive Leaf Extract (20% Oleuropein).
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What else affects it
Beyond other supplements
!
High sodium diet
Excessive sodium may counteract blood pressure benefits
Sodium promotes hypertension that olive extract helps reduce
!
Processed foods
High oxidative stress from processed foods may overwhelm antioxidant benefits
Counteracts antioxidant protectionHow it works
- Calcium channel blocking activity reduces blood pressure
- Oleuropein provides potent antioxidant protection to cardiovascular tissues
- Hydroxytyrosol enhances nitric oxide production improving vascular function
- Anti-inflammatory polyphenols reduce vascular inflammation
- Antimicrobial compounds support immune system function
- Improves endothelial function and arterial flexibility
Key findings
what the evidence supports- Modest but consistent blood pressure reduction
- Powerful antioxidant and anti-inflammatory effects
- Good safety profile with Mediterranean dietary tradition
- Promising immune support and antimicrobial properties
Sources: NIH Examine.com · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Olive Leaf Extract?
Documented effects: Blood pressure reduction; Powerful cardiovascular antioxidant protection; Cholesterol and lipid support; Immune system enhancement. Helps reduce both systolic and diastolic blood pressure naturally
How much Olive Leaf Extract should you take per day?
The common daily range is 250-1000mg. By goal — cardiovascular support: 500-1000mg daily; blood pressure support: 500-1000mg daily; immune support: 500-750mg daily; antioxidant support: 250-500mg daily.
When is the best time to take Olive Leaf Extract?
With food. First effects are typically reported within 2-4 weeks for cardiovascular and immune benefits.
What are the side effects of Olive Leaf Extract?
At excessive doses: Generally very safe with minimal side effects:, Blood pressure lowering effects, Mild digestive upset, Blood sugar effects, Rare allergic reactions. Safety rating at normal doses is 8 out of 10.
What should you not take with Olive Leaf Extract?
Separate it from High Sodium Diet, Processed Foods by two to four hours. Excessive sodium may counteract blood pressure benefits
Does Olive Leaf Extract interact with medications?
Documented interactions with blood-pressure-medications, diabetes-medications, chemotherapy. Discuss these with a pharmacist before combining.
How do you know if you need Olive Leaf Extract?
The marker is Blood pressure, antioxidant status, inflammatory markers, optimal range BP: <140/90 mmHg, low inflammatory markers. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, General symptoms addressed by olive leaf extract:, High blood pressure and cardiovascular stress, Poor antioxidant protection.