Blood sugar regulation and diabetes support
Helps maintain healthy blood glucose levels and insulin sensitivity
Maitake
Immune-supporting and blood sugar regulating medicinal mushroom with powerful beta-glucans for metabolic and immune health
Scientific nameGrifola frondosa
FormulaComplex beta-glucans and polysaccharides
Molecular weightVariable bioactive compounds g/mol
CASVarious natural compounds
70
absorption score
8
safety / 10
35
USD per month
5
documented interactions
Check it against something
Maitake with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Chromium GTF
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
78
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimEnhanced immune system function
Boosts immune response and natural killer cell activity
Weight management support
May help with weight loss and metabolic health
Cholesterol and heart health
May help reduce cholesterol and support cardiovascular health
Cancer support and protection
May support cancer treatment and provide protective effects
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Probiotics for Autoimmune Disease Support
Gut health & immune modulation
10-100 billion CFU daily
B
60%
Ashwagandha
Stress management & energy
300-600mg
A
75%
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Vitamin D3
Bone health & immune support
1000-2000 IU
A
85%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Every pair we checked
12 combinations scored by the engine
Maitake + Caffeine
No documented interaction either way
No known interaction
70
Maitake + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Maitake + Vitamin D3
No documented interaction either way
No known interaction
70
Maitake + Calcium Carbonate
No documented interaction either way
No known interaction
70
Maitake + Whey Protein
No documented interaction either way
No known interaction
70
Maitake + Lactase
No documented interaction either way
No known interaction
70
Maitake + Bovine Collagen
No documented interaction either way
No known interaction
70
Maitake + DHA
No documented interaction either way
No known interaction
70
Maitake + Turmeric
No documented interaction either way
No known interaction
70
Maitake + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Maitake + Berberine for Advanced Glucose Control and Metabolic Support
Enhanced blood sugar control and metabolic benefits
Works better together
75
Maitake + Chromium GTF
Enhanced blood sugar control and insulin sensitivity
Works better together
78
Dosage
Daily500-3000mg
Blood sugar support1000-3000mg daily
Immune enhancement500-2000mg daily
Metabolic health1000-2000mg daily
General wellness500-1000mg daily
Before you take it
VeganYes
When to expect it
First Effects2-4 weeks for blood sugar and immune benefits
Peak Benefits8-12 weeks for sustained metabolic and immune enhancement
Deficiency DevelopmentReturn to baseline glucose and immune function
Toxicity OnsetVery rare, mainly blood sugar effects
How to measure it
MarkerFasting glucose, HbA1c, insulin levels, or immune markers
OptimalImproved glucose control and enhanced immune function
Deficient belowNot applicable for supplement
FrequencyMonitor blood glucose regularly if diabetic, immune markers as needed
What actually reaches you
The label counts the carrier, your body does not
Absorption
High 70 of 100 · absorbs well relative to other forms
Delivered daily
1225 mg
Cost per 100 mg delivered
$0.10 comparative — uses the absorption score, not a measured percentage
Works better with
+
Chromium
Enhanced blood sugar control and insulin sensitivity
Both support glucose metabolism and insulin function · level B
+
Turkey Tail Mushroom
Enhanced immune function and cancer support
Complementary immune-supporting mushrooms · level B
+
Berberine
Enhanced blood sugar control and metabolic benefits
Both improve glucose metabolism through different pathways · level CWhat not to take with Maitake
!
High Sugar Diet
High sugar intake undermines blood sugar benefits
Excess glucose overwhelms metabolic improvements · moderate significance
!
Immunosuppressive Drugs
May counteract immunosuppressive effects
Maitake stimulates immune function · moderate significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance blood sugar lowering effects
What to do: Monitor blood glucose closely
May reduce effectiveness of immunosuppressive drugs
What to do: Monitor immune status
May have mild blood pressure lowering effects
What to do: Monitor blood pressure
Available forms
Maitake D-Fraction Extract: Most researched component, Standardized, High potency, Clinical backing
Standardized Beta-Glucan Extract: Standardized potency, Good bioavailability, Research backed, Quality controlled
Whole Mushroom Extract: Complete spectrum, Natural form, More affordable, Widely available
Whole Mushroom Powder: Lowest cost, Natural form, Culinary use, Traditional
Food sources
Fresh maitake mushrooms
Culinary amounts, lower medicinal potency · 45
Maitake extract supplements
500-3000mg per capsule · 70-85
Maitake powder
Variable concentration · 55
Maitake tea
Lower concentration · 50
Too little
- Not essential - but symptoms addressed by maitake:
- Poor blood sugar control and insulin resistance
- Frequent infections and immune dysfunction
- Metabolic syndrome and weight gain
- Poor cholesterol and cardiovascular health
- Increased cancer risk
- Chronic inflammation
Too much
- Generally safe but potential concerns:
- Hypoglycemia with diabetes medications
- Mild digestive upset
- Possible autoimmune stimulation
- Generally very well tolerated
Who benefits most
diabetes-blood-sugar-control
Excellent for supporting healthy blood glucose levels
1000-3000mg daily
immune-system-enhancement
Powerful immune booster and modulator
500-2000mg daily
metabolic-syndrome-weight
Supports metabolic health and weight management
1000-2000mg daily
cardiovascular-cholesterol
May help improve cholesterol and heart health
1000-2000mg daily
cancer-support-prevention
May provide immune support for cancer patients
1000-3000mg dailyWhere to buy it
Look for Maitake at 500-3000mg per serving. The form that matters here is Maitake D-Fraction Extract.
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What else affects it
Beyond other supplements
!
High sugar diet
High sugar intake undermines blood sugar benefits
Excess glucose overwhelms metabolic improvementsHow it works
- Beta-glucans improve insulin sensitivity and glucose metabolism
- D-fraction activates natural killer cells and immune response
- Polysaccharides modulate inflammatory pathways
- May inhibit alpha-glucosidase reducing glucose absorption
- Supports pancreatic beta cell function
- Enhances macrophage and dendritic cell activity
Key findings
what the evidence supports- Good evidence for blood sugar control and diabetes support
- Moderate evidence for immune enhancement
- Generally safe but monitor blood glucose with diabetes medications
- D-fraction extract has strongest research backing
Sources: NIH Examine.com · data reviewed 2026-08-01
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Maitake?
Documented effects: Blood sugar regulation and diabetes support; Enhanced immune system function; Weight management support; Cholesterol and heart health. Helps maintain healthy blood glucose levels and insulin sensitivity
How much Maitake should you take per day?
The common daily range is 500-3000mg. By goal — blood sugar support: 1000-3000mg daily; immune enhancement: 500-2000mg daily; metabolic health: 1000-2000mg daily; general wellness: 500-1000mg daily.
When is the best time to take Maitake?
With meals. First effects are typically reported within 2-4 weeks for blood sugar and immune benefits.
What are the side effects of Maitake?
At excessive doses: Generally safe but potential concerns:, Hypoglycemia with diabetes medications, Mild digestive upset, Possible autoimmune stimulation, Generally very well tolerated. Safety rating at normal doses is 8 out of 10.
What should you not take with Maitake?
Separate it from High Sugar Diet, Immunosuppressive Drugs by two to four hours. High sugar intake undermines blood sugar benefits
Does Maitake interact with medications?
Documented interactions with diabetes-medications, immunosuppressive-medications, blood-pressure-medications. Discuss these with a pharmacist before combining.
How do you know if you need Maitake?
The marker is Fasting glucose, HbA1c, insulin levels, or immune markers, optimal range Improved glucose control and enhanced immune function. Common deficiency signs: Not essential - but symptoms addressed by maitake:, Poor blood sugar control and insulin resistance, Frequent infections and immune dysfunction, Metabolic syndrome and weight gain.