Enhanced memory and learning
Significantly improves memory formation and learning capacity
Magnesium L-Threonate
Revolutionary magnesium form specifically designed to cross the blood-brain barrier for enhanced brain magnesium levels and cognitive function
Scientific nameMagnesium L-Threonate
FormulaC8H14MgO10
Molecular weight294.5 g/mol
CAS778571-57-6
95
absorption score
8
safety / 10
120
USD per month
8
elemental magnesium %
5
documented interactions
Check it against something
Magnesium L-Threonate with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
99
out of 100
Works better together
Compatible. Timing differs, so follow each supplement's own window.
What it does
mechanism and evidence for each claimSuperior blood-brain barrier penetration
Unique ability to cross blood-brain barrier and increase brain magnesium
Improved cognitive function
Enhances focus, attention, and overall cognitive performance
Enhanced neuroplasticity
Supports brain's ability to form new neural connections
Neuroprotective effects
May help protect against age-related cognitive decline
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Fish Oil (EPA/DHA)
Heart & brain health
1-2g EPA/DHA
A
85%
L-Theanine
Calm focus & stress relief
100-400mg
B
90%
Vitamin B8 (Inositol)
Mental health & PCOS support
2-18g (condition dependent)
B
95%
SAM-e
Mood support & liver health
400-800mg
A
70%
Lithium Orotate
Mood & brain support
1-20mg
C
60%
Or a different form of the same thing
the comparison people search most
Magnesium L-Threonate vs Magnesium Glycinate
absorption 95 against 90 ·
$120 against $25 a month
90%
Magnesium L-Threonate vs Magnesium Citrate
absorption 95 against 35 ·
$120 against $15 a month
35%
Magnesium L-Threonate vs Magnesium Oxide
absorption 95 against 4 ·
$120 against $8 a month
4%
Magnesium L-Threonate vs Magnesium Chloride
absorption 95 against 50 ·
$120 against $20 a month
50%
Magnesium L-Threonate vs Magnesium Malate
absorption 95 against 40 ·
$120 against $35 a month
40%
Every pair we checked
12 combinations scored by the engine
Magnesium L-Threonate + Caffeine
Very high caffeine may reduce magnesium effectiveness
Needs attention
58
Magnesium L-Threonate + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Whey Protein
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Lactase
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Bovine Collagen
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + DHA
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Turmeric
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Fish Oil (EPA/DHA)
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Magnesium Oxide
No documented interaction either way
No known interaction
70
Magnesium L-Threonate + Calcium Carbonate
Required for proper calcium metabolism
Works better together
82
Magnesium L-Threonate + Vitamin C (Ascorbic Acid)
Vitamin D supports neuroplasticity and brain function
Works better together
90
Magnesium L-Threonate + Vitamin D3
Vitamin D supports neuroplasticity and brain function
Works better together
99
Dosage
Daily2000-4000 mg
Maintenance2000-3000 mg daily
Therapeutic3000-4000 mg daily
Cognitive enhancement2000-4000 mg daily (divided)
Elemental magnesiumContains ~8% elemental magnesium
Upper limit
350 mg from supplements NIH ODS
Before you take it
VeganYes
When to expect it
First Effects2-6 weeks for initial cognitive improvements
Peak Benefits12-24 weeks for maximum cognitive and memory benefits
Deficiency DevelopmentWeeks to months with inadequate intake
Toxicity OnsetVery rare, mainly mild headaches or digestive upset
How to measure it
MarkerBrain magnesium (research only), cognitive assessments
OptimalCognitive testing more relevant than blood levels
Deficient belowNot applicable for this specialized form
FrequencyCognitive assessments every 6-12 months
Brain penetration is key benefit, not blood levels
What people actually reported to the FDA
CAERS, 379 reports naming it as the suspectMost reported effects
Excluded from the list above: choking (55), foreign body (27), dysphagia (22). Those are people struggling with the tablet itself, not with the compound.
Named as the suspect
379 reports
of 1,000+ that mention it at all
Serious outcome
87%
hospitalisation, emergency room or worse
Other Serious or Important Medical Event283
Hospitalization81
Visited Emergency Room53
Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →
What actually reaches you
The label counts the carrier, your body does not
Elemental magnesium
8.3%
of 294.5 g/mol
Absorption
Very high 95 of 100 · best absorbed form of this compound
Delivered daily
236.6 mg
Cost per 100 mg delivered
$1.69 comparative — uses the absorption score, not a measured percentage
A 500 mg capsule of Magnesium L-Threonate contains 42 mg of magnesium. How much of that crosses into your blood is not measured for this form — the absorption score ranks it against other forms, it is not a share of the dose. How this is calculated →
Works better with
+
Vitamin D
Vitamin D supports neuroplasticity and brain function
Complementary effects on neuronal health and function · level B
+
Omega 3 Dha
DHA essential for brain structure and function
Complementary brain health and cognitive support · level A
+
B Vitamins
B vitamins support neurotransmitter synthesis
Cofactors for brain metabolism complement magnesium · level AWhat not to take with Magnesium L-Threonate
!
Aluminum
Aluminum may interfere with magnesium brain function
Competitive interference in neuronal systems · mild significance
!
Excessive Caffeine
Very high caffeine may reduce magnesium effectiveness
Potential interference with neuronal magnesium utilization · mild significanceMedication interactions
Discuss these with a pharmacist before combiningMay enhance effects of cognitive medications
What to do: Monitor for enhanced effects
May affect seizure threshold
What to do: Consult physician before use
Magnesium may reduce antibiotic absorption
What to do: Space doses 2-4 hours apart
Available forms
Best absorbed form of Magnesium — 95% against 5 alternatives. Compare all forms →
Magnesium L-Threonate (Magtein): Brain penetration, Cognitive research, Memory enhancement, Neuroplasticity support
Food sources
Magnesium L-threonate not found in foods
Only available as patented supplement · 95
Vitamin C rich foods (source of threonate)
Minimal L-threonate production · 10
Brain-healthy foods
Support overall brain health · Variable
Too little
- Poor memory and learning difficulties
- Reduced cognitive performance
- Brain fog and mental fatigue
- Difficulty concentrating
- Age-related cognitive decline
- Poor neuroplasticity
- Reduced mental clarity
Too much
- Generally excellent safety profile:
- Mild headaches in some users
- Possible digestive upset with high doses
- No serious adverse effects reported in studies
Who benefits most
cognitive-enhancement-seekers
Specifically designed for brain health and cognitive function
2000-4000 mg daily (divided doses)
students-professionals
May enhance learning, memory, and mental performance
2000-3000 mg daily
aging-adults-memory-concerns
May help maintain cognitive function with aging
2000-4000 mg daily
brain-health-optimization
Premium choice for comprehensive brain health support
2000-3000 mg daily
nootropic-users
Advanced cognitive enhancement supplement
2000-4000 mg dailyWhere to buy it
Look for Magnesium L-Threonate at 2000-4000 mg per serving. The form that matters here is Magnesium L-Threonate (Magtein).
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What else affects it
Beyond other supplements
!
Aluminum
Aluminum may interfere with magnesium brain function
Competitive interference in neuronal systems
!
Excessive caffeine
Very high caffeine may reduce magnesium effectiveness
Potential interference with neuronal magnesium utilizationHow it works
- L-threonate facilitates transport across blood-brain barrier
- Increases brain magnesium concentrations by up to 15%
- Enhances NMDA receptor function critical for learning and memory
- Supports synaptic plasticity and neuronal communication
- Optimizes neurotransmitter synthesis and release
- Protects against excitotoxicity and neuronal damage
Key findings
what the evidence supports- Increases brain magnesium levels by 15% in animal studies
- Improves learning and memory in aging mouse models
- Enhances synaptic plasticity markers in preclinical research
- Promising preliminary human cognitive studies
Sources: NIH Examine.com PubMed 20152124 · data reviewed 2026-08-02
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Magnesium L-Threonate?
Documented effects: Enhanced memory and learning; Superior blood-brain barrier penetration; Improved cognitive function; Enhanced neuroplasticity. Significantly improves memory formation and learning capacity
How much Magnesium L-Threonate should you take per day?
The common daily range is 2000-4000 mg. By goal — maintenance: 2000-3000 mg daily; therapeutic: 3000-4000 mg daily; cognitive enhancement: 2000-4000 mg daily (divided); elemental magnesium: Contains ~8% elemental magnesium.
When is the best time to take Magnesium L-Threonate?
Morning afternoon divided. First effects are typically reported within 2-6 weeks for initial cognitive improvements.
What are the side effects of Magnesium L-Threonate?
At excessive doses: Generally excellent safety profile:, Mild headaches in some users, Possible digestive upset with high doses, No serious adverse effects reported in studies. Safety rating at normal doses is 8 out of 10.
What should you not take with Magnesium L-Threonate?
Separate it from Aluminum, Excessive Caffeine by two to four hours. Aluminum may interfere with magnesium brain function
Does Magnesium L-Threonate interact with medications?
Documented interactions with cognitive-medications, antiepileptic-drugs, antibiotics-tetracycline. Discuss these with a pharmacist before combining.
How much Magnesium L-Threonate is too much?
The tolerable upper intake level is 350 mg from supplements per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: Generally excellent safety profile:, Mild headaches in some users, Possible digestive upset with high doses.
How do you know if you need Magnesium L-Threonate?
The marker is Brain magnesium (research only), cognitive assessments, optimal range Cognitive testing more relevant than blood levels. Common deficiency signs: Poor memory and learning difficulties, Reduced cognitive performance, Brain fog and mental fatigue, Difficulty concentrating.