Check a pair

Cordyceps

Parasitic fungus traditionally used for energy, endurance, respiratory health, and overall vitality enhancement

Scientific nameCordyceps sinensis/militaris FormulaComplex bioactive compounds Molecular weightVariable natural compounds g/mol CASVarious bioactive compounds
75 absorption score
8 safety / 10
60 USD per month
5 documented interactions

Check it against something

Evidence level B

Cordyceps with:

Compatibility score 78 out of 100
78 out of 100
Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Enhanced energy and endurance

Improves physical performance, stamina, and energy levels

Increases ATP production and oxygen utilization efficiency Evidence B-grade 2-6 weeks

Improved respiratory function

Supports lung health and breathing capacity

Enhances oxygen uptake and bronchodilation Evidence B-grade 4-8 weeks

Immune system modulation

Balances and strengthens immune function

Contains polysaccharides that modulate immune response Evidence B-grade 3-8 weeks

Kidney and adrenal support

Supports kidney function and adrenal health

Traditional adaptogenic effects on kidney-adrenal axis Evidence C-grade 6-12 weeks

Blood sugar regulation

May help maintain healthy blood glucose levels

Compounds may improve insulin sensitivity Evidence C-grade 4-12 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

Every pair we checked

12 combinations scored by the engine
Cordyceps + Caffeine May cause overstimulation when combined Needs attention 61
Cordyceps + Creatine Monohydrate No documented interaction either way No known interaction 70
Cordyceps + Calcium Carbonate No documented interaction either way No known interaction 70
Cordyceps + Whey Protein No documented interaction either way No known interaction 70
Cordyceps + Lactase No documented interaction either way No known interaction 70
Cordyceps + Bovine Collagen No documented interaction either way No known interaction 70
Cordyceps + DHA No documented interaction either way No known interaction 70
Cordyceps + Turmeric No documented interaction either way No known interaction 70
Cordyceps + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70
Cordyceps + Rhodiola Rosea Enhanced adaptogenic and performance benefits Works better together 78
Cordyceps + Coenzyme Q10 (CoQ10) Enhanced cellular energy and ATP production Works better together 78
Cordyceps + Vitamin D3 Enhanced energy metabolism and performance Works better together 78

Dosage

Morning with meals
Daily500-3000mg
General health500-1000mg daily
Athletic performance1000-3000mg daily
Respiratory support1000-2000mg daily
Immune modulation500-1500mg daily

Before you take it

VeganYes

When to expect it

First Effects2-4 weeks for energy and endurance benefits
Peak Benefits6-12 weeks for sustained performance and health benefits
Deficiency DevelopmentReturn to baseline energy and performance levels
Toxicity OnsetVery rare, mainly overstimulation effects

How to measure it

$200-300
MarkerVO2 max, energy markers, or immune function tests
OptimalImproved exercise capacity and immune markers
Deficient belowNot applicable for supplement
FrequencyMonitor performance metrics and energy levels

What people actually reported to the FDA

CAERS, 32 reports naming it as the suspect

Most reported effects

Vomiting 4
Blood pressure increased 3
Loss of consciousness 3
Headache 2
Hypertension 2

Excluded from the list above: gastrointestinal obstruction (2). Those are people struggling with the tablet itself, not with the compound.

Named as the suspect 32 reports of 38 that mention it at all
Serious outcome 89% hospitalisation, emergency room or worse
Other Serious Outcome21
Hospitalization12
Visited Emergency Room10

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not
Absorption High 75 of 100 · absorbs well relative to other forms
Delivered daily 1312.5 mg
Cost per 100 mg delivered $0.15 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented
+
Rhodiola Rosea

Enhanced adaptogenic and performance benefits

Complementary adaptogenic herbs for stress and performance · level B
+
Coq10

Enhanced cellular energy and ATP production

Both support mitochondrial energy production · level B
+
B Complex Vitamins

Enhanced energy metabolism and performance

B vitamins required for energy production pathways · level B

What not to take with Cordyceps

2 documented
!
Immunosuppressive Drugs

May counteract immunosuppressive effects

Cordyceps stimulates immune function · moderate significance
!
Caffeine Excess

May cause overstimulation when combined

Both can increase energy and stimulation · minor significance

Medication interactions

Discuss these with a pharmacist before combining
diabetes-medications Moderate

May enhance blood sugar lowering effects

What to do: Monitor blood glucose closely

blood-thinners Minor

May enhance anticoagulant effects

What to do: Monitor bleeding parameters

immunosuppressive-medications Moderate

May reduce effectiveness of immunosuppressive drugs

What to do: Avoid in organ transplant patients

Available forms

bioavailability compared
Cordyceps Sinensis Extract 75
Cordyceps Militaris Extract 80

Cordyceps Sinensis Extract: Traditional variety, Well-studied, Premium quality, Authentic

Cordyceps Militaris Extract: Cultivated, More affordable, Sustainable, Higher cordycepin

Food sources

before you supplement
Wild Cordyceps sinensis Rare and extremely expensive · 80
Cordyceps extract supplements 500-3000mg per capsule · 75-80
Cordyceps powder Variable concentration · 70
Cordyceps tea Lower concentration · 60

Too little

deficiency signs
  • Not essential - but symptoms addressed by cordyceps:
  • Chronic fatigue and low energy
  • Poor athletic performance and endurance
  • Respiratory weakness and poor lung function
  • Frequent infections and immune dysfunction
  • Poor stress tolerance and adrenal fatigue
  • Reduced vitality and premature aging

Too much

toxicity signs
  • Generally safe but potential concerns:
  • Overstimulation and restlessness
  • Autoimmune flares in susceptible individuals
  • Hypoglycemia with diabetes medications
  • Increased bleeding with blood thinners

Who benefits most

athletes-endurance-performance

Excellent for improving athletic performance and endurance

1000-3000mg daily
fatigue-low-energy

Effective for boosting energy and combating fatigue

500-1500mg daily
respiratory-lung-health

Supports lung function and respiratory capacity

1000-2000mg daily
immune-support-modulation

Helps balance and strengthen immune function

500-1500mg daily
aging-vitality-longevity

Traditional anti-aging and vitality enhancement

500-1000mg daily

Where to buy it

compare forms first

Look for Cordyceps at 500-3000mg per serving. The form that matters here is Cordyceps Sinensis Extract.

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What else affects it

Beyond other supplements
!
Caffeine excess

May cause overstimulation when combined

Both can increase energy and stimulation

How it works

  • Increases ATP production and cellular energy metabolism
  • Enhances oxygen utilization and VO2 max capacity
  • Modulates immune function through polysaccharides
  • Supports adrenal and kidney function through adaptogenic effects
  • Improves blood flow and circulation
  • Contains cordycepin and other bioactive nucleosides

Key findings

what the evidence supports
  • Good evidence for athletic performance and endurance enhancement
  • Promising for respiratory function and lung health
  • Moderate evidence for immune modulation and energy
  • Generally safe but monitor for drug interactions

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Cordyceps?

Documented effects: Enhanced energy and endurance; Improved respiratory function; Immune system modulation; Kidney and adrenal support. Improves physical performance, stamina, and energy levels

How much Cordyceps should you take per day?

The common daily range is 500-3000mg. By goal — general health: 500-1000mg daily; athletic performance: 1000-3000mg daily; respiratory support: 1000-2000mg daily; immune modulation: 500-1500mg daily.

When is the best time to take Cordyceps?

Morning with meals. First effects are typically reported within 2-4 weeks for energy and endurance benefits.

What are the side effects of Cordyceps?

At excessive doses: Generally safe but potential concerns:, Overstimulation and restlessness, Autoimmune flares in susceptible individuals, Hypoglycemia with diabetes medications, Increased bleeding with blood thinners. Safety rating at normal doses is 8 out of 10.

What should you not take with Cordyceps?

Separate it from Immunosuppressive Drugs, Caffeine Excess by two to four hours. May counteract immunosuppressive effects

Does Cordyceps interact with medications?

Documented interactions with diabetes-medications, blood-thinners, immunosuppressive-medications. Discuss these with a pharmacist before combining.

How do you know if you need Cordyceps?

The marker is VO2 max, energy markers, or immune function tests, optimal range Improved exercise capacity and immune markers. Common deficiency signs: Not essential - but symptoms addressed by cordyceps:, Chronic fatigue and low energy, Poor athletic performance and endurance, Respiratory weakness and poor lung function.

Taken for