Superior bioavailability
Better absorbed than sulfate and other inorganic copper forms
Copper Bisglycinate
Highly bioavailable chelated copper essential for collagen synthesis, iron metabolism, and antioxidant function
Scientific nameCopper Bisglycinate Chelate
FormulaC4H8CuN2O4
Molecular weight211.66 g/mol
CAS13479-54-4
85
absorption score
6
safety / 10
12
USD per month
30
elemental copper %
6
documented interactions
Check it against something
Copper Bisglycinate with:
- Amylase
- Ashwagandha
- Avocado Oil
- BCAA (Branched-Chain Amino Acids)
- Beetroot Powder
- Beta-Alanine
- Bifidobacterium lactis
- Bifidobacterium longum
- Bovine Collagen
- Caffeine
- Calcium
- Calcium Bone Formula
- Calcium Carbonate
- Casein Protein
- Chicken Collagen
- Choline (Bitartrate)
- Chondroitin Sulfate
- Coconut Oil
- Collagen Peptides
- Comprehensive Immune Support Complex
- Comprehensive Multivitamin-Mineral Complex
- Creatine HCL
- Creatine Monohydrate
- D-Mannose
- DHA
- Electrolyte Blend
- EPA
- Fish Oil (EPA/DHA)
- Folate (5-MTHF)
- Ginger
- Iron Bisglycinate
- Iron Fumarate
- Iron Sulfate
- Joint Mobility Formula
- Keratin
- Krill Oil
- L-Carnitine
- L-Citrulline
- Lactase
- Lactobacillus acidophilus
- Lactobacillus rhamnosus
- Lipase
- Magnesium Citrate
- Magnesium Glycinate
- Magnesium Oxide
- Marine Collagen
- Melatonin
- Modafinil
- Olive Oil Extract
- Omega-3 + Curcumin + Vitamin D Triple Anti-Inflammatory Formula
- Papain
- Protease
- Saccharomyces boulardii
- Turmeric
- Vitamin B12 (Cyanocobalamin)
- Vitamin B12 (Methylcobalamin)
- Vitamin C (Ascorbic Acid)
- Vitamin C (Sodium Ascorbate)
- Vitamin D3
- Whey Protein
- Zinc Gluconate
Nothing found
82
out of 100
Needs attention
Separate by 2-4 hours to avoid the interaction below.
What it does
mechanism and evidence for each claimEnhanced collagen synthesis
Essential for healthy skin, joints, and blood vessels
Improved iron metabolism
Essential for proper iron utilization and transport
Antioxidant enzyme support
Critical for superoxide dismutase antioxidant function
Cardiovascular health
Supports healthy blood vessels and heart function
Others take these for the same thing
Same goal, different mechanism — check any of them against this one
Ashwagandha
Stress management & energy
300-600mg
A
75%
Vitamin B12 (Cyanocobalamin)
Energy & nerve support
250-1000 mcg
A
70%
Coenzyme Q10 (CoQ10)
Heart health & cellular energy
100-200mg
A
10%
Collagen Peptides
Skin health & joint support
5-15g
B
85%
Phosphorus
Bone health & energy metabolism
700-1250mg
A
80%
Bone Broth Collagen
Gut healing & collagen support
20-40g powder
B
85%
Every pair we checked
12 combinations scored by the engine
Copper Bisglycinate + Zinc Gluconate
High zinc dramatically reduces copper absorption
Needs attention
22
Copper Bisglycinate + Caffeine
No documented interaction either way
No known interaction
70
Copper Bisglycinate + Creatine Monohydrate
No documented interaction either way
No known interaction
70
Copper Bisglycinate + Calcium Carbonate
No documented interaction either way
No known interaction
70
Copper Bisglycinate + Whey Protein
No documented interaction either way
No known interaction
70
Copper Bisglycinate + Lactase
No documented interaction either way
No known interaction
70
Copper Bisglycinate + Bovine Collagen
No documented interaction either way
No known interaction
70
Copper Bisglycinate + DHA
No documented interaction either way
No known interaction
70
Copper Bisglycinate + Iron Sulfate
High iron may compete with copper absorption
Needs attention
82
Copper Bisglycinate + Vitamin D3
Both support collagen synthesis
Works better together
82
Copper Bisglycinate + Iron Fumarate
High iron may compete with copper absorption
Needs attention
82
Copper Bisglycinate + Manganese Bisglycinate
Both involved in antioxidant enzyme systems
Works better together
90
Dosage
Daily1-3 mg
Maintenance0.9-2 mg
Therapeutic2-5 mg
Upper limit10 mg daily
Elemental copperContains ~13% elemental copper
Upper limit
10 mg NIH ODS
Before you take it
VeganYes
When to expect it
First Effects2-4 weeks for enzyme function improvements
Peak Benefits8-16 weeks for collagen and cardiovascular benefits
Deficiency DevelopmentWeeks to months with inadequate intake
Toxicity OnsetWeeks to months with excessive intake
How to measure it
MarkerSerum copper, ceruloplasmin, or 24-hour urine copper
OptimalSerum copper: 70-140 μg/dL, Ceruloplasmin: 20-50 mg/dL
Deficient belowSerum copper: <70 μg/dL
FrequencyEvery 6-12 months if supplementing or taking high-dose zinc
What actually reaches you
The label counts the carrier, your body does not
Elemental copper
30%
of 211.66 g/mol
Absorption
Very high 85 of 100 · best absorbed form of this compound
Delivered daily
0.5 mg
Cost per 10 mg delivered
$7.84 comparative — uses the absorption score, not a measured percentage
A 500 mg capsule of Copper Bisglycinate contains 150 mg of copper. How much of that crosses into your blood is not measured for this form — the absorption score ranks it against other forms, it is not a share of the dose. How this is calculated →
Works better with
+
Iron
Copper essential for iron utilization and transport
Required for ceruloplasmin and iron oxidation · level A
+
Vitamin C
Both support collagen synthesis
Complementary roles in collagen formation · level A
+
Manganese
Both involved in antioxidant enzyme systems
Different but complementary SOD enzymes · level BWhat not to take with Copper Bisglycinate
!
Zinc High Dose
High zinc dramatically reduces copper absorption
Competition for metallothionein binding and absorption · major significance
!
Vitamin C Megadose
Very high vitamin C may reduce copper absorption
Potential interference with copper uptake · moderate significance
!
Iron High Dose
High iron may compete with copper absorption
Mineral competition for transporters · mild significanceMedication interactions
Discuss these with a pharmacist before combiningDrug chelates copper reducing levels
What to do: Copper supplementation often required
High zinc reduces copper absorption dramatically
What to do: Maintain proper zinc:copper ratio (8-15:1)
Available forms
Copper Bisglycinate Chelate: Superior absorption, Gentle on stomach, Better utilization, Stable form
Food sources
Copper bisglycinate not found naturally in foods
Only available as supplement · 85
Organ meats (liver)
2-5mg per 100g · 75
Shellfish (oysters)
1-4mg per 100g · 70
Nuts and seeds
0.3-1.5mg per 100g · 60
Too little
- Anemia that doesn't respond to iron
- Neutropenia (low white blood cell count)
- Osteoporosis and bone abnormalities
- Cardiovascular problems
- Premature graying of hair
- Skin and connective tissue disorders
- Neurological problems
Too much
- Wilson's disease symptoms (genetic)
- Liver damage and cirrhosis
- Neurological deterioration
- Kidney damage
- Gastrointestinal upset
- Hemolysis (red blood cell destruction)
Who benefits most
zinc-supplement-users
Need copper to balance high zinc supplementation
1-2 mg daily (maintain 8-15:1 zinc:copper ratio)
collagen-joint-health
Essential for collagen synthesis and joint health
1-3 mg daily
iron-deficiency-anemia
Required for proper iron utilization
1-2 mg daily
cardiovascular-health
Important for blood vessel integrity
1-2 mg daily
premature-graying-hair
Copper deficiency can cause premature graying
1-2 mg dailyWhere to buy it
Look for Copper Bisglycinate at 1-3 mg per serving. The form that matters here is Copper Bisglycinate Chelate.
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How it works
- Essential cofactor for lysyl oxidase in collagen cross-linking
- Required for ceruloplasmin iron transport protein
- Critical component of cytochrome c oxidase for energy production
- Essential for Cu/Zn-superoxide dismutase antioxidant enzyme
- Required for dopamine and norepinephrine synthesis
- Involved in melanin production and pigmentation
Key findings
what the evidence supports- Essential for collagen synthesis and connective tissue health
- Critical for iron metabolism and anemia prevention
- Important antioxidant enzyme cofactor (Cu/Zn-SOD)
- Deficiency often caused by excessive zinc supplementation
Sources: NIH Examine.com · data reviewed 2026-08-01
Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →
Common questions
What are the benefits of Copper Bisglycinate?
Documented effects: Superior bioavailability; Enhanced collagen synthesis; Improved iron metabolism; Antioxidant enzyme support. Better absorbed than sulfate and other inorganic copper forms
How much Copper Bisglycinate should you take per day?
The common daily range is 1-3 mg. By goal — maintenance: 0.9-2 mg; therapeutic: 2-5 mg; upper limit: 10 mg daily; elemental copper: Contains ~13% elemental copper.
When is the best time to take Copper Bisglycinate?
With food. First effects are typically reported within 2-4 weeks for enzyme function improvements.
What are the side effects of Copper Bisglycinate?
At excessive doses: Wilson's disease symptoms (genetic), Liver damage and cirrhosis, Neurological deterioration, Kidney damage, Gastrointestinal upset. Safety rating at normal doses is 6 out of 10.
What should you not take with Copper Bisglycinate?
Separate it from Zinc High Dose, Vitamin C Megadose, Iron High Dose by two to four hours. High zinc dramatically reduces copper absorption
Does Copper Bisglycinate interact with medications?
Documented interactions with penicillamine, zinc-supplements. Discuss these with a pharmacist before combining.
How much Copper Bisglycinate is too much?
The tolerable upper intake level is 10 mg per day for adults, per NIH ODS. Above that, the risk of adverse effects rises: Wilson's disease symptoms (genetic), Liver damage and cirrhosis, Neurological deterioration.
How do you know if you need Copper Bisglycinate?
The marker is Serum copper, ceruloplasmin, or 24-hour urine copper, optimal range Serum copper: 70-140 μg/dL, Ceruloplasmin: 20-50 mg/dL. Common deficiency signs: Anemia that doesn't respond to iron, Neutropenia (low white blood cell count), Osteoporosis and bone abnormalities, Cardiovascular problems.