Celery Seed Extract

Traditional herbal extract from celery seeds containing phthalides that support healthy blood pressure

Scientific nameApium graveolens Formula3-n-butylphthalide (NBP) and other phthalides Molecular weight190.24 (NBP) g/mol CAS6066-49-5

70 absorption score

8 safety / 10

20 USD per month

5 documented interactions

Check it against something

Evidence level C

Celery Seed Extract with:

75 out of 100

Works better together Compatible. Timing differs, so follow each supplement's own window.

Check it against your whole stack →

What it does

mechanism and evidence for each claim

Mild blood pressure reduction

Gentle lowering of both systolic and diastolic pressure

Phthalides relax smooth muscle and promote diuresis Evidence B-grade 3-6 weeks

Natural diuretic effects

Promotes healthy fluid balance and reduces retention

Increases urine production and sodium excretion Evidence B-grade 1-2 weeks

Smooth muscle relaxation

Helps relax blood vessel walls for better circulation

Phthalides act as calcium channel blockers Evidence C-grade 2-4 weeks

Anti-inflammatory support

Reduces inflammation in cardiovascular system

Antioxidant compounds reduce inflammatory markers Evidence C-grade 4-8 weeks

Kidney function support

Supports healthy kidney function and filtration

Improves renal blood flow and function Evidence C-grade 4-8 weeks

Others take these for the same thing

Same goal, different mechanism — check any of them against this one

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Every pair we checked

12 combinations scored by the engine

Celery Seed Extract + Caffeine May counteract some cardiovascular benefits Needs attention 58

Celery Seed Extract + Creatine Monohydrate No documented interaction either way No known interaction 70

Celery Seed Extract + Calcium Carbonate No documented interaction either way No known interaction 70

Celery Seed Extract + Whey Protein No documented interaction either way No known interaction 70

Celery Seed Extract + Lactase No documented interaction either way No known interaction 70

Celery Seed Extract + Bovine Collagen No documented interaction either way No known interaction 70

Celery Seed Extract + DHA No documented interaction either way No known interaction 70

Celery Seed Extract + Turmeric No documented interaction either way No known interaction 70

Celery Seed Extract + Fish Oil (EPA/DHA) No documented interaction either way No known interaction 70

Celery Seed Extract + Potassium Citrate Enhanced blood pressure lowering and electrolyte balance Works better together 75

Celery Seed Extract + Magnesium Oxide Additional smooth muscle relaxation and BP support Works better together 75

Celery Seed Extract + Vitamin D3 Enhanced antioxidant and vascular protection Works better together 75

Dosage

With food

Daily300-600mg extract

Traditional use300-600mg standardized extract daily

Blood pressure400-800mg daily divided doses

Diuretic support300-500mg daily

MaximumDo not exceed 1000mg daily

When to expect it

First Effects1-3 weeks for diuretic and mild BP effects

Peak Benefits6-8 weeks for optimal cardiovascular support

Deficiency DevelopmentNot applicable - herbal supplement

Toxicity OnsetRare, mainly photosensitivity concerns

How to measure it

$60-100

MarkerBlood pressure, kidney function, electrolytes

OptimalBP: <120/80 mmHg, Normal kidney function

Deficient belowNot applicable for herbal supplement

FrequencyMonthly monitoring for blood pressure and kidney function

What people actually reported to the FDA

CAERS, 2 reports naming it as the suspect

Most reported effects

Atrial fibrillation 1

Dilatation atrial 1

Dyspnoea 1

Echocardiogram abnormal 1

Heart valve incompetence 1

Named as the suspect 2 reports of 5 that mention it at all

Serious outcome 80% hospitalisation, emergency room or worse

Other Serious or Important Medical Event2

Hospitalization1

Visited Emergency Room1

Reports are voluntary and unverified — they record what someone experienced while taking something, not what the compound caused. Counts skew towards products people take a lot of, and a serious outcome is more likely to be reported than a mild one, so these are not rates. How we filter them →

What actually reaches you

The label counts the carrier, your body does not

Absorption High 70 of 100 · absorbs well relative to other forms

Delivered daily 315 mg

Cost per 100 mg delivered $0.21 comparative — uses the absorption score, not a measured percentage

Works better with

3 documented

Potassium

Enhanced blood pressure lowering and electrolyte balance

Complementary effects on sodium-potassium balance · level C

Magnesium

Additional smooth muscle relaxation and BP support

Complementary calcium channel blocking effects · level C

Vitamin C

Enhanced antioxidant and vascular protection

Synergistic antioxidant effects · level C

What not to take with Celery Seed Extract

2 documented

Excessive Sodium

Counteracts diuretic and BP-lowering effects

High sodium opposes natural diuretic benefits · moderate significance

Caffeine

May counteract some cardiovascular benefits

Stimulant effects can oppose relaxation · mild significance

Medication interactions

Discuss these with a pharmacist before combining

diuretics Moderate

May enhance diuretic effects

What to do: Monitor fluid balance and electrolytes

blood-pressure-medications Moderate

May enhance hypotensive effects

What to do: Monitor blood pressure closely

photosensitizing-medications Minor

May increase photosensitivity risk

What to do: Use sun protection

Available forms

bioavailability compared

Standardized Extract (85% phthalides) 70

Standardized Extract (85% phthalides): Traditional use, Gentle effects, Natural diuretic, Good safety profile

Food sources

before you supplement

Celery seeds (dried fruits) High concentration of phthalides · 60

Fresh celery stalks Lower concentration of active compounds · 50

Standardized extracts Concentrated phthalides (85%+) · 70

Traditional tea preparations Variable compound content · 55

Too little

deficiency signs

Not applicable (herbal supplement, not essential nutrient):
Conditions addressed by celery seed:
Mild blood pressure elevation
Fluid retention and bloating
Poor circulation
Kidney function concerns
Joint inflammation and arthritis

Too much

toxicity signs

Generally safe but potential concerns:
Increased photosensitivity and sunburn risk
Kidney irritation with very high doses
Excessive diuresis and dehydration
Interaction with blood pressure medications

Who benefits most

mild-hypertension

Gentle support for early-stage blood pressure elevation

300-600mg standardized extract daily

fluid-retention

Natural diuretic effects help with water retention

300-500mg daily

traditional-medicine-users

Prefer time-tested traditional remedies

Following traditional preparation methods

kidney-support

May support healthy kidney function

200-400mg daily

arthritis-inflammation

Traditional use for joint inflammation

400-600mg daily

Where to buy it

compare forms first

Look for Celery Seed Extract at 300-600mg extract per serving. The form that matters here is Standardized Extract (85% phthalides).

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What else affects it

Beyond other supplements

Excessive sodium

Counteracts diuretic and BP-lowering effects

High sodium opposes natural diuretic benefits

How it works

Phthalides (especially NBP) relax smooth muscle in blood vessels
Natural diuretic effects reduce blood volume and pressure
Calcium channel blocking properties promote vasodilation
Anti-inflammatory effects reduce vascular inflammation
Improves kidney function and sodium excretion
Antioxidant properties protect cardiovascular system

Key findings

what the evidence supports

Traditional use supported by preliminary research
Mild but consistent blood pressure lowering effects
Generally safe with minimal side effects
May provide additional benefits for kidney function and inflammation

Sources: NIH Examine.com · data reviewed 2026-08-02

Compiled by Denis, who maintains this database and holds no medical qualification — every figure here is sourced or derived, never asserted. How we calculate it →

Common questions

What are the benefits of Celery Seed Extract?

Documented effects: Mild blood pressure reduction; Natural diuretic effects; Smooth muscle relaxation; Anti-inflammatory support. Gentle lowering of both systolic and diastolic pressure

How much Celery Seed Extract should you take per day?

The common daily range is 300-600mg extract. By goal — traditional use: 300-600mg standardized extract daily; blood pressure: 400-800mg daily divided doses; diuretic support: 300-500mg daily; maximum: Do not exceed 1000mg daily.

When is the best time to take Celery Seed Extract?

With food. First effects are typically reported within 1-3 weeks for diuretic and mild BP effects.

What are the side effects of Celery Seed Extract?

At excessive doses: Generally safe but potential concerns:, Increased photosensitivity and sunburn risk, Kidney irritation with very high doses, Excessive diuresis and dehydration, Interaction with blood pressure medications. Safety rating at normal doses is 8 out of 10.

What should you not take with Celery Seed Extract?

Separate it from Excessive Sodium, Caffeine by two to four hours. Counteracts diuretic and BP-lowering effects

Does Celery Seed Extract interact with medications?

Documented interactions with diuretics, blood-pressure-medications, photosensitizing-medications. Discuss these with a pharmacist before combining.

How do you know if you need Celery Seed Extract?

The marker is Blood pressure, kidney function, electrolytes, optimal range BP: <120/80 mmHg, Normal kidney function. Common deficiency signs: Not applicable (herbal supplement, not essential nutrient):, Conditions addressed by celery seed:, Mild blood pressure elevation, Fluid retention and bloating.

Taken for

52 Heart

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