Vitamin B12 (Methylcobalamin) + Folate (5-MTHF)
Compatible. Timing differs, so follow each supplement's own window.
Verdict
Timing plan
Can be taken togetherNothing blocks them — the same window is what produces the synergy below.
What helps
Vitamin B12 (Methylcobalamin) → Folate (5-MTHF)
Complementary roles in one-carbon metabolism · level AFolate (5-MTHF) → Vitamin B12 (Methylcobalamin)
Complementary roles in one-carbon metabolism · level ASide by side
| Vitamin B12 (Methylcobalamin) | Folate (5-MTHF) | |
|---|---|---|
| Bioavailability | 85% | 95% |
| Safety rating | 10/10 | 9/10 |
| Cost per month | $15 | $20 |
| Daily dose | 500-1000 mcg | 400-800 mcg |
| Best timing | Morning sublingual | Morning with food |
| Evidence level | A | A |
How this score was built
- Baseline for any untested pair: 70
- +12 — synergy at evidence level A
- +12 — synergy at evidence level A
- = 94 out of 100
Where to buy
Buying both? Check the timing plan above so they do not cancel each other out.
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Common questions
Can you take Vitamin B12 (Methylcobalamin) and Folate (5-MTHF) together?
Compatible. Timing differs, so follow each supplement's own window. The pair scores 94 out of 100, based on 2 documented interaction records.
What should you not take with Vitamin B12 (Methylcobalamin)?
Nothing in this pairing clashes. Its own page lists everything Vitamin B12 (Methylcobalamin) is documented to conflict with.
When should you take Vitamin B12 (Methylcobalamin) and Folate (5-MTHF)?
Vitamin B12 (Methylcobalamin): Morning sublingual. Folate (5-MTHF): Morning with food. The same window works for both.