Check a pair

Calcium and Magnesium together

Checked on Calcium and Magnesium Glycinate — the best-absorbed forms people actually buy. Other forms of the same two behave the same way here: the interaction belongs to the mineral, not to the carrier.

Separate by 2-4 hours to avoid the interaction below.

64 compatibility
1 synergy
1 conflict

Verdict

Evidence level A
Compatibility score 64 out of 100
64 out of 100
Needs attention Separate by 2-4 hours to avoid the interaction below.

Timing plan

Separate them
Calcium Divided doses with meals 1,000-1,200 mg
wait 2–4 hours
Magnesium Glycinate Evening with or without food 200-600 mg

These two compete on absorption. Splitting the day keeps both effective.

What clashes

1 documented
!
High calcium can interfere with magnesium absorption

Magnesium Glycinate → Calcium

Competition for absorption pathways · moderate

What helps

1 documented
+
Essential for calcium metabolism and bone health

Calcium → Magnesium Glycinate

Magnesium regulates calcium transport and parathyroid hormone function · level A

What each one is for

Two different jobs — that is why the pairing question comes up at all

Calcium — bone health & muscle function.

Usual daily dose 1,000-1,200 mg, taken divided doses with meals. The ceiling is 2500 mg a day (NIH ODS). It is named as the suspect product in 569 FDA reports. Evidence grade A.

Magnesium Glycinate — superior absorption sleep & muscle support.

Usual daily dose 200-600 mg, taken evening with or without food. The ceiling is 350 mg from supplements a day (NIH ODS). It is named as the suspect product in 379 FDA reports. Evidence grade A.

Side by side

CalciumMagnesium Glycinate
Absorption score 30/100 90/100
Elemental mineral 100% 14.1%
Cost per 100 mg delivered $0.2 $1.64
Safety rating 8/10 9/10
Cost per month $20 $25
Daily dose 1,000-1,200 mg 200-600 mg
Best timing Divided doses with meals Evening with or without food
Evidence level A A

How this score was built

  • Baseline for any untested pair: 70
  • +12 — synergy at evidence level A
  • −18 — moderate clinical conflict
  • = 64 out of 100

Where to buy

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Buying both? Check the timing plan above so they do not cancel each other out.

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Common questions

Can you take Calcium and Magnesium Glycinate together?

Separate by 2-4 hours to avoid the interaction below. The pair scores 64 out of 100, based on 2 documented interaction records.

What should you not take with Calcium?

In this pairing the issue is: High calcium can interfere with magnesium absorption Separate them by two to four hours.

When should you take Calcium and Magnesium Glycinate?

Calcium: Divided doses with meals. Magnesium Glycinate: Evening with or without food. Keep at least a two-hour gap between them.

Where to go next